Is the SCID mouse model applicable to human acute lung injury?

In reply

“…We again appreciate the comments on our article 1 and the interest it has raised 2‐4 . However, for the benefit of public health, the focus of the debate on safety of pathogen reduction technology (PRT)‐treated platelets (PLTs) should be centered on the results of the clinical trials.…”

In reply

“…We appreciate the opportunity to respond to the comments by Corash and Stassinopoulos 1 regarding our in vivo SCID mouse model of acute lung injury (ALI) associated with UVB irradiated platelets (PLTs) 2 . A discussion regarding this topic is important since a resolution of the respiratory distress safety signals identified in the SPRINT 3 trial is central to assessing the significance of these findings.…”