Is the spleen stiffness value acquired, using acoustic radiation force impulse (ARFI) technology, predictive of the presence of esophageal varices in patients with cirrhosis of various etiologies?

Park, Jae-Hyung; Kwon, Heejin; Cho, Jinhan; Oh, Joo Yeon; Lee, Sangyun; Han, Sang-Yeong; Lee, Sung Wook; Baek, Yang-Hyun

doi:10.11152/mu.2013.2066.181.sff

Cited by 4 publications

(3 citation statements)

References 21 publications

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“…Moreover, some studies have shown that spleen stiffness value acquired using ARFI may predict the presence of oesophageal varices in cirrhotic patients. In particular, Park et al[32] demonstrated that the AST to ALT ratio score, APRI score, PLT, PLT/spleen diameter ratio and spleen elastography variables were all independently associated with oesophageal varices. However, the multivariate analysis revealed that only spleen elastography was associated with oesophageal varices.…”

Section: Emerging Non-invasive Assessment Of Extensive Fibrosis or CImentioning

confidence: 99%

Evolving strategies for liver fibrosis staging: The non-invasive assessment

Stasi

Milani

2017

WJG

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Transient elastography and the acoustic radiation force impulse techniques may play a pivotal role in the study of liver fibrosis. Some studies have shown that elastography can detect both the progression and regression of fibrosis. Similarly, research results have been analysed and direct and indirect serum markers of hepatic fibrosis have shown high diagnostic accuracy for advanced fibrosis/cirrhosis. The prognosis of different stages of cirrhosis is well established and various staging systems have been proposed, largely based on clinical data. However, it is still unknown if either non-invasive markers of liver fibrosis or elastography may contribute to a more accurate staging of liver cirrhosis, in terms of prognosis and fibrosis regression after effective therapy. In fact, not enough studies have shown both the fibrosis regression in different cirrhosis stages and the point beyond which the prognosis does not change - even in the event of fibrosis regression. Therefore, future studies are needed to validate non-invasive methods in predicting the different phases of liver cirrhosis.

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Section: Emerging Non-invasive Assessment Of Extensive Fibrosis or CImentioning

confidence: 99%

Evolving strategies for liver fibrosis staging: The non-invasive assessment

Stasi

Milani

2017

WJG

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“…However, Park et al demonstrates that the usefulness of spleen elastography in detecting esophageal varices depends on the cause of cirrhosis. According to this study spleen elastography is not a reliable predictor of esophageal varices induced by alcoholic cirrhosis ( 33 ) . According to available studies, spleen elastography is not useful in assessing the grade of esophageal varices ( 27 , 33 – 35 ) .…”

Section: Correlation Between Portal Hypertension Esophageal Varices mentioning

confidence: 79%

“…According to this study spleen elastography is not a reliable predictor of esophageal varices induced by alcoholic cirrhosis ( 33 ) . According to available studies, spleen elastography is not useful in assessing the grade of esophageal varices ( 27 , 33 – 35 ) . Single studies show that spleen stiffness correlates with clinical history of variceal bleeding ( 36 – 37 ) , but its utility in determining the risk of bleeding from esophageal varices requires further investigation.…”

Section: Correlation Between Portal Hypertension Esophageal Varices mentioning

confidence: 79%

Clinical applications of spleen ultrasound elastography – a review

Mazur¹,

Celmer

Silicki

et al. 2018

J Ultrason

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In the last few years, notable technical progress has taken place in ultrasound elastography. Qualitative methods have been replaced by quantitative ones, such as: transient elastography, acoustic radiation force impulse and shear wave elastography. Owing to the fact that the spleen is superficially located, it is possible to obtain reliable measuring accuracy of its hardness using sonoelastography. Lately, many researchers have been investigating how spleen elasticity changes in patients infected with hepatitis B virus or hepatitis C virus and in patients suffering from liver fibrosis, portal hypertension, esophageal varices or myelofibrosis. In this article, we review the role and current status of accessible qualitative ultrasound elastography methods, including recent advances in the evaluation of spleen stiffness and its clinical utility. As study results demonstrate, spleen stiffness correlates with liver fibrosis and is helpful in determining the level of fibrosis in the METAVIR scoring system. In patients infected with hepatitis B virus or hepatitis C virus, spleen stiffness increases even when liver elasticity remains unaltered. Furthermore, it is useful in diagnosing portal hypertension or predicting existence of esophageal varices. Moreover, in patients suffering from biliary atresia after Kasai portoenterostomy, spleen sonoelastography may be helpful in selecting patients for liver transplantation as well as for choosing the best strategy for portal vein reconstruction before liver transplantation. In myelofibrosis, spleen stiffness correlates with bone marrow fibrosis and may be used to assess the response to treatment. Spleen sonoelastography is also useful in the monitoring of transjugular intrahepatic portosystemic shunt function.

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The relationship of spleen stiffness value measured by shear wave elastography with age, gender, and spleen size in healthy volunteers

Albayrak

Server

2019

J Med Ultrasonics

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Is the spleen stiffness value acquired, using acoustic radiation force impulse (ARFI) technology, predictive of the presence of esophageal varices in patients with cirrhosis of various etiologies?

Cited by 4 publications

References 21 publications

Evolving strategies for liver fibrosis staging: The non-invasive assessment

Evolving strategies for liver fibrosis staging: The non-invasive assessment

Clinical applications of spleen ultrasound elastography – a review

The relationship of spleen stiffness value measured by shear wave elastography with age, gender, and spleen size in healthy volunteers

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