Is there a possible link between chronic trauma of the palate induced by a maxillary denture and the appearance of melanoma? Discussion of two case reports and a review of the literature

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References1 Yannicelli S, Ryan A. Improvements in behaviour and physical manifestations in previously untreated adults with phenylketonuria using a phenylalaninerestricted diet: a national survey. J Inherit Metab Dis 1995; 18: 131-134. 2 Lin SY, Nui DM, Tu CP, Cheng YD, Lin HL. Evidence of L-cysteinesulfinic acid in PKY neonatal hair roots, with disappearance after dietary control. Ultrastruct Pathol 2000; 24: 351-352. 3 Itin PH, Fistarol SK. Hair shaft abnormalities -clues to diagnosis and treatment. Dermatology 2005; 211: 63-71. 4 VanSande M. Hair amino acids: normal values and results in metabolic errors. Arch Dis Child 1970; 45: 678-681. 5 Wiest LG, Lutz P, Jung EG, Paweletz N. Morphological and biochemical investigations of hairs in inborn errors of amino acid metabolism. Arch Dermatol Res 1976; 256: 53-65. 6 Olsen EA. Diffuse alopecia: telogen hair loss. Figure 2Hyperpigmented macular lesion over the hard palate, under the denture.