The worth of using Silver Diamine Fluoride (SDF) during COVID-19 pandemic has highly increased due to its low invasiveness and non-aerosolizing technique. The blend of silver and fluoride in an alkaline solution has a great action in arresting active enamel and dentin carious lesions, also acting as a desensitizer to lessen dentine hypersensitivity in adults, this review article was conducted to highlight the SDF mechanism of action, clinical applications, and its main indications and contraindications.