Is There a Role for Polyunsaturated Fatty Acids in the Prevention of Renal Disease and Renal Failure?

Barcelli, Uno; Pollak, Victor E.

doi:10.1159/000183584

Cited by 37 publications

(12 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A number of previous observations have demonstrated the beneficial effects of n-3 free fatty acid supplementation in the treatment of experimental renal diseases [25][26][27][28]. On the other hand, Shiina et al [17] reported that EPA inhibited the proliferation of cultured rat VSMC and that this effect of EPA was reversed by the addition of antioxidants, suggesting that production of the oxidized species at a low concentration from EPA inhibited VSMC proliferation.…”

Section: Discussionmentioning

confidence: 99%

Eicosapentaenoic Acid Inhibits Mitogen-Induced Endothelin-1 Production and DNA Synthesis in Cultured Bovine Mesangial Cells

Nitta

Uchida²,

Tsutsui³

et al. 1998

Am J Nephrol

View full text Add to dashboard Cite

The present study was designed to examine whether eicosapentaenoic acid (EPA) inhibits the production of basal or stimulated endothelin (ET)-1 by platelet-derived growth factor (PDGF)-BB or epidermal growth factor (EGF), and DNA synthesis in cultured bovine mesangial cells. PDGF-BB and EGF stimulated ET-1 secretion in a dose-dependent fashion in these cells. EPA (10–100 µM) exhibited dose-related inhibition of PDGF-BB- and EGF-stimulated ET-1 secretion. EPA had no inhibitory effects on basal ET-1 secretion in these cells. Moreover, 50 µM EPA significantly attenuated PDGF-BB- and EGF-stimulated [³H]thymidine incorporation into mesangial cells. Receptor-binding experiments showed that EPA competitively inhibited ¹²⁵I-PDGF-BB or ¹²⁵I-EGF binding to mesangial cell surface receptors. Scatchard analysis for PDGF-BB receptor or EGF receptor revealed a linear regression fit and one binding site. Pretreatment with 50 µM EPA suppressed the number of maximum binding sites, but did not affect the K_d values. These results indicate that EPA potentially inhibits mesangial cell ET-1 production, when stimulated by PDGF-BB or EGF. This inhibitory effect of EPA could be related to the attenuation of mesangial cell proliferation via inhibition of the binding of PDGF-BB or EGF to their receptors due to alteration of the physicochemical characteristics of the cell membrane.

show abstract

Section: Discussionmentioning

confidence: 99%

Eicosapentaenoic Acid Inhibits Mitogen-Induced Endothelin-1 Production and DNA Synthesis in Cultured Bovine Mesangial Cells

Nitta

Uchida²,

Tsutsui³

et al. 1998

Am J Nephrol

View full text Add to dashboard Cite

show abstract

“…A marked increase in proteinuria was observed in both CRF groups, suggesting that glomerular selectivity was compromised to the same extent in both groups. Some studies have shown that dietary supplementation with PUFAs reduces proteinuria and prevents functional deterioration in immune complex glomerulonephritis, and in genetic systemic lupus erythematosus (2,3,8). Dietary supplementation by linoleic acid prevented functional deterioration after subtotal nephrectomy in rats (37).…”

Section: Discussionmentioning

confidence: 99%

“…The protein diet has been extensively studied, together with some other dietary components. Lipids and precursors of some autacoids like prostaglandins and leukotrienes have also been implicated in the progression of CRF (2)(3)(4). Dietary prostaglandin precursors are different in different parts of the world.…”

Section: Introductionmentioning

confidence: 99%

“…It is present in many vegetable oils and is the precursor of arachidonic acid. Some beneficial effects of PUFAs, especially linoleic acid, are related to the reduction of blood pressure (18,19), platelet aggregability and blood viscosity (2,5). Subtotally nephrectomized rats fed a low linoleic acid diet had progressive deterioration of renal function.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of dietary linoleic acid on the progression of chronic renal failure in rats

Gregório

Lemos

Caldas

et al. 2002

Braz J Med Biol Res

View full text Add to dashboard Cite

The role of linoleic acid in chronic renal failure (CRF) is controversial. In the present study 21 male Wistar rats submitted to 5/6 renal mass reduction (R) and 16 normal controls (C) were fed a supplement (S) or normal (N) linoleic acid diet for 60 days starting 10 days after CRF. As expected, serum creatinine, cholesterol and triglycerides (mean ± SEM) were higher in the CRF groups compared to the C groups (P<0.05). The RS group presented lower cholesterol (84 ± 4 vs 126 ± 13 mg%) and triglyceride (88 ± 9 vs 132 ± 19 mg%) levels compared to the RN group. Proteinuria and kidney weight did not differ between CRF groups. Glomerular area increased 78% in RS and 100% in RN compared to control rats. Glomerular sclerosis index tended to be lower in RS (27%) compared to RN (38%), tubulointerstitial damage was similar between CRF groups (RS = 1.91 ± 0.2 and RN = 2.14 ± 0.3), and mesangial fractional volume increased to the same extent in both CRF groups. The data suggest that a linoleic acid-enriched diet did not protect against the progression of CRF after 60 days.

show abstract

“…One possibility is that increasing linoleic acid intake alters the systemical and renal synthesis ofvasoactive prostaglandins such as prostaglandin E2, I2 and thromboxanes through an effect on arachidonic acid availability in the cyclooxygenase pathway [44,45]. In normal subjects, creatinine clearance rose after a linoleic-acid-rich diet, possibly as the result of enhanced synthesis of the vasodilatory prostaglandin E2 [12].…”

Section: Discussionmentioning

confidence: 99%

Long-term effects of linoleic-acid-enriched diet on albuminuria and lipid levels in Type 1 (insulin-dependent) diabetic patients with elevated urinary albumin excretion

Dullaart¹,

Beusekamp

Meijer³

et al. 1992

Diabetologia

View full text Add to dashboard Cite

Summary. We conducted a 2-year prospective randomised study to investigate the effects of a linoleic-acid-enriched diet on albuminuria and lipid levels in Type 1 (insulin-dependent) diabetic patients with elevated urinary albumin excretion (overnight urinary albumin excretion rate between 10 and 200 gg/min). Thirty-eight patients were randomly assigned to increase dietary polyunsaturated:saturated fatty acids ratio to 1.0 by replacement of saturated fat with linoleicacid-rich products (n = 18, two dropouts, analysis was performed in n = 16) or to continue their usual diet (n = 20). The total fat and protein content of the diet was unaltered. Clinical characteristics, albuminuria, blood pressure, glomerular filtration rate, metabolic control and dietary composition were similar in the two groups at baseline. In the high linoleic acid diet group, linoleic intake rose from 7 + 4 to 11 + 2 energy % and polyunsaturated: saturated fatty acids ratio rose from 0.60 _+ 0.28 to 0.96 + 0.16 (p < 0.001 compared to usual diet group). The median increase albuminuria was 58% (95 % confidence interval, 13 to 109) during the first year (p <0.02) and 55% (95% confidence interval, 11 to 127) (p < 0.01) during the second year. Glomerular filtration rate remained unaltered and filtration fraction tended to rise (p < 0.05 compared to usual diet group). In the usual diet group, albuminuria did not significantly increase by 16 % (95 % confidence interval, -17 to 38) and glomerular filtration rate declined during the second year. Blood pressure tended to rise similarly in both groups. Multiple regression analysis showed an independent effect of the high linoleic acid diet on the progression of albuminuria as well as the lack of decrease in glomerular filtration rate. Low density lipoprotein cholesterol and apolipoprotein B levels decreased in the high linoleic acid diet group (p < 0.05). High density lipoprotein cholesterol declined in both groups (p < 0.05). It is concluded that a linoleic-acid-enriched diet reduces atherogenic lipoproteins but does not have a beneficial effect on and might even promote renal functional abnormalities in Type 1 diabetic patients with elevated urinary albumin excretion.

show abstract

Is There a Role for Polyunsaturated Fatty Acids in the Prevention of Renal Disease and Renal Failure?

Cited by 37 publications

References 19 publications

Eicosapentaenoic Acid Inhibits Mitogen-Induced Endothelin-1 Production and DNA Synthesis in Cultured Bovine Mesangial Cells

Eicosapentaenoic Acid Inhibits Mitogen-Induced Endothelin-1 Production and DNA Synthesis in Cultured Bovine Mesangial Cells

Effect of dietary linoleic acid on the progression of chronic renal failure in rats

Long-term effects of linoleic-acid-enriched diet on albuminuria and lipid levels in Type 1 (insulin-dependent) diabetic patients with elevated urinary albumin excretion

Contact Info

Product

Resources

About