Is There a Role for Hyperbaric Oxygen Therapy in Reducing Long-Term COVID-19 Sequelae?

Oliaei, Shahram; Paranjkhoo, Parinaz; SeyedAlinaghi, SeyedAhmad; Mehraeen, Esmaeil; Hackett, Daniel

doi:10.3390/jcm12062270

Cited by 2 publications

(2 citation statements)

References 10 publications

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“…3,10 HBOT has been proposed as a potential therapy to address the effects of hypoxia contributing to these symptoms. 11 An initial study was conducted in 2021; since then, more research is assessing the therapy with more rigorous study designs. 12 Post-COVID-19 condition is a complex health condition that presents an important challenge to health care decision-makers in Canada…”

Section: Who Might Benefit?mentioning

confidence: 99%

Hyperbaric Oxygen Therapy: An Emerging Therapy for Post–COVID-19 Condition

Basharat¹,

Spry²

2023

cjht

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What Is the Issue? Post–COVID-19 condition presents an important challenge to health care decision-makers in Canada and across the world due to the high volume of potential patients, diverse presentations of symptoms, few clinical guidelines and treatments, and unknown pathophysiology. What Is the Technology? Hyperbaric oxygen therapy (HBOT) is an established treatment for certain wound injuries, vascular conditions, and in specific medical emergencies. It is now being tested for post–COVID-19 condition, also known as long COVID. The therapy delivers a high concentration of oxygen inside specialized pressure chambers. HBOT has been proposed as a treatment to help resolve prominent symptoms of post–COVID-19 condition, such as fatigue and brain fog. The therapy may induce physiological changes that aid in recovering from the long-term effects and tissue damage due to severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) infection. What Is the Potential Impact? Results from early studies indicate that HBOT could improve a range of post–COVID-19 symptoms and its use is generally safe with few adverse effects. These results are based on 2 randomized control trials and small nonrandomized studies and case reports. However, published results have been based on studies with limited sample sizes and limited long-term follow-up. HBOT could offer a therapy option that could support millions of people around the world with post–COVID-19 condition if the ongoing and subsequent studies show efficacy. What Else Do We Need to Know? As of now, there are uncertainties about how to effectively deliver and dose the therapy and the potential safety implications for people with post–COVID-19 condition. Implementation considerations, such as the number and location of hyperbaric oxygen chambers, will be important if HBOT is appropriate for a large number of people. As the evidence base develops, the potential role of HBOT in therapy for people with post–COVID-19 condition will become clearer and will provide an indication of what kind of health system planning may be needed to provide HBOT for those who can benefit.

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Section: Who Might Benefit?mentioning

confidence: 99%

Hyperbaric Oxygen Therapy: An Emerging Therapy for Post–COVID-19 Condition

Basharat¹,

Spry²

2023

cjht

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“…Fourteen medical applications have been accepted by UHMS [20]. Recent clinical and preclinical results have suggested the potential usefulness of HBOT in treating long COVID-19 [21][22][23][24][25][26][27][28][29][30][31]. In particular, in neurological tissues, Zilberman-Itskovich et al (2022) [32] provided some interesting observations about the effects of hyperbaric therapy on perfusion; in myocardial function, Leitman et al (2023) [27] suggested that HBOT can indicate subclinical left ventricular dysfunction.…”

Section: Introductionmentioning

confidence: 99%

Hyperbaric Oxygen Therapy Counters Oxidative Stress/Inflammation-Driven Symptoms in Long COVID-19 Patients: Preliminary Outcomes

Mrakic-Sposta,

Vezzoli,

Garetto

et al. 2023

Metabolites

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Long COVID-19 patients show systemic inflammation and persistent symptoms such as fatigue and malaise, profoundly affecting their quality of life. Since improving oxygenation can oppose inflammation at multiple tissue levels, we hypothesized that hyperbaric oxygen therapy (HBOT) could arrest inflammation progression and thus relieve symptoms of COVID-19. We evaluated oxy-inflammation biomarkers in long COVID-19 subjects treated with HBOT and monitored with non-invasive methods. Five subjects (two athletes and three patients with other comorbidities) were assigned to receive HBOT: 100% inspired O2 at 2.4 ATA in a multiplace hyperbaric chamber for 90 min (three athletes: 15 HBOT × 5 days/wk for 3 weeks; two patients affected by Idiopathic Sudden Sensorineural Hearing Loss: 30 HBOT × 5 days/wk for 6 weeks; and one patient with osteomyelitis: 30 HBOT × 5 days/wk for week for 6 weeks and, after a 30-day break, followed by a second cycle of 20 HBOT). Using saliva and/or urine samples, reactive oxygen species (ROS), antioxidant capacity, cytokines, lipids peroxidation, DNA damage, and renal status were assessed at T1_pre (basal level) and at T2_pre (basal level after treatment), and the results showed attenuated ROS production, lipid peroxidation, DNA damage, NO metabolites, and inflammation biomarker levels, especially in the athletes post-treatment. Thus, HBOT may represent an alternative non-invasive method for treating long COVID-19-induced long-lasting manifestations of oxy-inflammation.

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Is There a Role for Hyperbaric Oxygen Therapy in Reducing Long-Term COVID-19 Sequelae?

Abstract: The COVID-19 pandemic has plagued our society for approximately three years [...]

Cited by 2 publications

References 10 publications

Hyperbaric Oxygen Therapy: An Emerging Therapy for Post–COVID-19 Condition

Hyperbaric Oxygen Therapy: An Emerging Therapy for Post–COVID-19 Condition

Hyperbaric Oxygen Therapy Counters Oxidative Stress/Inflammation-Driven Symptoms in Long COVID-19 Patients: Preliminary Outcomes

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