Is There a Role for Antiplatelet Therapy in Infective Endocarditis? A Review of Current Scientific Evidence

Abstract

Recently, interest has emerged regarding adjuvant antiplatelet therapy in infective endocarditis (IE) and its impact on clinical outcomes. Despite ongoing research, the role of antiplatelet therapy in this setting remains unclear. Generally, investigations of IE are limited by the low incidence of the disease, practical issues related to diagnosis, and the highly variable latency period between symptom onset and definitive diagnosis. This article reviews the rationale for using antiplatelet therapy in the setting of IE and the contemporary literature that investigates its use.

Detachment of Breast Tumor Cells Induces Rapid Secretion of Exosomes Which Subsequently Mediate Cellular Adhesion and Spreading

“…Adhesion is exceedingly important not only in cancer biology but other pathological conditions including cardiovascular disorders [8], [9]. It is generally assumed that integrins on the cell surface are the major if not the only players in extracellular matrix adhesion [10].…”