2023
DOI: 10.1161/jaha.122.026270
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Is There a Sex Difference in the Prognosis of Hypertrophic Cardiomyopathy? A Systematic Review and Meta‐Analysis

Abstract: Background It is still unclear whether there is a sex difference in the prognosis of patients with hypertrophic cardiomyopathy (HCM). Therefore, we performed a meta‐analysis to elucidate the association between sex and adverse outcomes in patients with HCM. Methods and Results The PubMed, Cochrane Library, and Embase databases were used to search for studies on sex differences in prognosis in patients with HCM up to August 17, 2021. Summa… Show more

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Cited by 15 publications
(8 citation statements)
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“…This study revealed a significant association between female sex and an elevated risk of all-cause mortality compared to male sex in patients with HCM. These findings are consistent with previous meta-analyses that have reported similar outcomes ( 34 , 37 ). Subgroup analysis based on data matching demonstrated that even within the data matching group where heterogeneity was absent, women continued to exhibit a higher risk of all-cause mortality compared to men.…”
Section: Discussionsupporting
confidence: 93%
See 3 more Smart Citations
“…This study revealed a significant association between female sex and an elevated risk of all-cause mortality compared to male sex in patients with HCM. These findings are consistent with previous meta-analyses that have reported similar outcomes ( 34 , 37 ). Subgroup analysis based on data matching demonstrated that even within the data matching group where heterogeneity was absent, women continued to exhibit a higher risk of all-cause mortality compared to men.…”
Section: Discussionsupporting
confidence: 93%
“…The analysis of the arrhythmic endpoint did not yield any statistically significant differences between the female and male groups. This finding aligns with previous meta-analyses that have reported a lack of association between female sex and an increased risk of ventricular arrhythmias and SCD ( 37 ). Subgroup analysis based on sample size revealed a lack of heterogeneity within the subgroup comprising studies with a sample size of less than 1,000, yet women exhibited a higher risk of the arrhythmic endpoint compared to men.…”
Section: Discussionsupporting
confidence: 92%
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“…In our cohort, we observed some sex-based differences in baseline characteristics that are consistent with previous studies [31]. Typically, females with HCM are diagnosed and recruited for research at a later age, which may explain the increased prevalence of symptoms and more advanced HF.…”
Section: Discussionsupporting
confidence: 86%