Is there a treatment protocol in which platelet-rich plasma is effective?

Yılmaz, İbrahim; Akkaya, Semih; Isyar, Mehmet; Batmaz, Ahmet Güray; Güler, Olcay; Öznam, Kadir; Uğraş, Akın; Mahiroğulları, Mahir

doi:10.1016/j.jor.2016.06.027

Cited by 11 publications

(10 citation statements)

References 42 publications

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“…There is currently no literature to quantify variability in amount of platelet content among patients. Hence, differences in platelet concentration would be present for the same amount of blood drawn, 26 which can affect overall clinical results.…”

Section: Discussionmentioning

confidence: 99%

Additive Effect of Plasma Rich in Growth Factors With Guided Tissue Regeneration in Treatment of Intrabony Defects in Patients With Chronic Periodontitis: A Split‐Mouth Randomized Controlled Clinical Trial

Ravi

Malaiappan

Varghese

et al. 2017

Journal of Periodontology

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Section: Discussionmentioning

confidence: 99%

Additive Effect of Plasma Rich in Growth Factors With Guided Tissue Regeneration in Treatment of Intrabony Defects in Patients With Chronic Periodontitis: A Split‐Mouth Randomized Controlled Clinical Trial

Ravi

Malaiappan

Varghese

et al. 2017

Journal of Periodontology

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“…However, it was not mentioned for what type of treatment each extraction kit was used. Therefore, is important to know the types of kits used to obtain the platelets and their use in different treatments [84]. In the specific case of the treatment of chronic cutaneous ulcers with PRP, PRP can work well even when the ulcers are from different etiologies.…”

Section: Platelet-rich Plasma (Prp)mentioning

confidence: 99%

Diabetic Foot Ulcers: Current Advances in Antimicrobial Therapies and Emerging Treatments

et al. 2019

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Diabetic foot ulcers (DFUs) are very important diabetes-related lesions that can lead to serious physical consequences like amputations of limbs and equally severe social, psychological, and economic outcomes. It is reported that up to 25% of patients with diabetes develop a DFU in their lifetime, and more than half of them become infected. Therefore, it is essential to manage infection and ulcer recovery to prevent negatives outcomes. The available information plays a significant role in keeping both physicians and patients aware of the emerging therapies against DFUs. The purpose of this review is to compile the currently available approaches in the managing and treatment of DFUs, including molecular and regenerative medicine, antimicrobial and energy-based therapies, and the use of plant extracts, antimicrobial peptides, growth factors, ozone, devices, and nano-medicine, to offer an overview of the assessment of this condition.2 of 32 history [2]. DFUs are one of the most severe complications of diabetes, and more than half of those ulcers become infected. Every single one of these infected lesions has the potential to get worse and compromise the integrity of the lower limbs. To avoid amputations and improve the patient's quality of life, it is very important to implement a strict program for the prevention and treatment of ulcers, as well as proper management of infections [3]. Thus, it is critical to keep diabetes patients aware of new therapies and treatments and their availability in the healthcare system. The treatment of DFUs requires a multidisciplinary approach with proper medical tools, skills, and knowledge. This starts from patient education, with the application of new classifications to guide the treatment to prevent amputations. New diagnosis methods should become available, such as the 16S ribosomal DNA sequence in bacteria, to provide a better understanding of the microbiota in DFUs. It is reported that DFU has a polymicrobial nature, and, according to its geographical location, certain marked differences, wound characteristics, antibiograms according to local epidemiology, individualized antimicrobial guided therapy, regular debridement, regular assessment of wounds, and change of dressings. The latter characteristics are also aided by new biological and molecular therapies that were proven to improve infection control, the regulation of the local inflammatory profile, and improved quality of the cicatrizing process. In the next sections, this review presents an approach for the diagnosis and treatment of DFUs, focusing on the current advances in antimicrobial therapies, such as dressings,

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“…Accordingly, the evidence levels of randomized clinical trials or multiple clinical trials with significant treatment effects were as follows: We excluded studies with a level of evidence of "F" and which were performed on animals, and mechanical models, since we were interested only in clinical trials. While creating a flow chart revealing the number and reasons of excluded and included studies at each stage of the selection process, the standards for reporting the results of a systematic review, the transparency in the presentation of the results, and determining the common issues amongst the reviews were provided by "the Transparent Reporting of the Systematic Review (PRISMA)" (10,19,20,38,39,46). In this way, all the articles were examined during the design phase and the form of reporting was determined.…”

Section: Literature Search Strategymentioning

confidence: 99%

“…Frequently cited articles were identified in Web of Science and Scopus databases. The references and citations of all articles were examined to avoid possible repetitions (Figure 1) (10,44,46).…”

Section: Literature Search Strategymentioning

confidence: 99%

Systematic evaluation of promising clinical trials—gene silencing for the treatment of glioblastoma

Karaarslan

Yılmaz²,

Özbek³

et al. 2018

Turkish Neurosurgery

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Is there a treatment protocol in which platelet-rich plasma is effective?

Cited by 11 publications

References 42 publications

Additive Effect of Plasma Rich in Growth Factors With Guided Tissue Regeneration in Treatment of Intrabony Defects in Patients With Chronic Periodontitis: A Split‐Mouth Randomized Controlled Clinical Trial

Additive Effect of Plasma Rich in Growth Factors With Guided Tissue Regeneration in Treatment of Intrabony Defects in Patients With Chronic Periodontitis: A Split‐Mouth Randomized Controlled Clinical Trial

Diabetic Foot Ulcers: Current Advances in Antimicrobial Therapies and Emerging Treatments

Systematic evaluation of promising clinical trials—gene silencing for the treatment of glioblastoma

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