Is There a Way to Predict Granulosa Cell Tumor of the Ovary? The Role of Peripheral Blood Test Parameters

Abstract

Objective: As the clinical characteristics and clinical presentation of granulosa cell tumour of the ovary (GCTO) are not specific, predictive markers are required. The aim of this study was to evaluate the use of peripheral blood parameters in the preoperative prediction of GCTO. Method: This retrospective case-control study included 34 patients with GCTO (Group 1) and 158 females with benign ovarian mass (Group 2). Data were recorded and the groups were compared in respect of age, gravida, parity, neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) and red cell distribution width (RDW). Results: With the exception of age, no difference was determined between the groups in respect of the other demographic parameters. In the study group, the RDW values were lower and NLR and PLR were higher than in the control group. The differences between the groups were statistically significant (p=0.003, p=0.013, p=0.038, respectively). The cutoff values obtained from the ROC curve for RDW, NLR and PLR were 14.3, 2.03 and 129.3, respectively. RDW was the only marker with sensitivity (67.6%) and specificity (65.8%) over 60%. In the study group a positive correlation was determined between tumour diameter and NLR (r=0.46, p=0.006). Conclusion: Although increased RDW is a strong determinant of mortality, including cancer-related deaths, the results of this study showed decreased RDW in GCTO. Low RDW could possibly be used as a screening tool in GCTO.