Is there an association between diabetes and neck pain and lower back pain? Results of a population-based study

Jiménez‐García, Rodrigo; Barrio, José Luis del; Hernández‐Barrera, Valentín; Miguel-Díez, Javier de; Jiménez‐Trujillo, Isabel; Martínez-Huedo, Maria A.; López‐de‐Andrés, Ana

doi:10.2147/jpr.s158877

Cited by 26 publications

(33 citation statements)

References 36 publications

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“…Diabetes is increasing in prevalence worldwide, with possible serious implications 2. An association between diabetes and LBP has been indicated in some population studies 3 4. Other studies have suggested a relationship between increased blood glucose levels and LBP 5 6.…”

Section: Introductionmentioning

confidence: 99%

Does diabetes influence the probability of experiencing chronic low back pain? A population-based cohort study: the Nord-Trøndelag Health Study

Heuch

Hagen

et al. 2019

BMJ Open

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ObjectiveLow back pain (LBP) is a major problem in modern society and it is important to study possible risk factors for this disorder. People with diabetes are often affected by LBP, but whether diabetes represents a risk factor for LBP has not been studied in detail. The aim of this study was to explore the association between diabetes and subsequent risk of chronic LBP.DesignAn 11-year follow-up study.SettingThe Nord-Trøndelag Health Study (HUNT2; 1995–1997) and HUNT3 (2006–2008) surveys of Nord-Trøndelag County in Norway.Main outcome measureChronic LBP, defined as LBP persisting at least 3 months continuously during the last year.ParticipantsA total of 18 972 persons without chronic LBP at baseline in HUNT2, and 6802 persons who reported chronic LBP at baseline in HUNT2.MethodsAssociations between diabetes and risk of chronic LBP among individuals aged 30–69 years were examined by generalised linear modelling.ResultsMen without chronic LBP at baseline showed a significant association between diabetes and risk of chronic LBP (relative risk (RR) 1.43, 95% CI 1.04 to 1.96, p=0.043). In women, no association was found (RR 1.01, 95% CI 0.69 to 1.48, p=0.98). No association could be established between diabetes and recurrence or persistence of chronic LBP after 11 years in either sex.ConclusionsMen with a diagnosis of diabetes may have a higher risk of subsequently experiencing chronic LBP.

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Section: Introductionmentioning

confidence: 99%

Does diabetes influence the probability of experiencing chronic low back pain? A population-based cohort study: the Nord-Trøndelag Health Study

Heuch

Hagen

et al. 2019

BMJ Open

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“…Bone turnover markers (BTMs), which is an indicator for the rate of bone formation and resorption, has been shown to deteriorate in patients with T2DM as well 18. These signs and symptoms, combined with high prevalence of vertebral bone pain in the T2DM population, suggest that managing T2DM-induced bone disease is crucial to improving the patients’ quality of life and clinical outcomes 19…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic and antiosteoporotic pharmacotherapies for prevention and treatment of type 2 diabetes-induced bone disease: protocol for two network meta-analyses

et al. 2020

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IntroductionPatients with type 2 diabetes mellitus (T2DM) are at risk for a variety of severe debilitating effects. One of the most serious complications experienced by patients with T2DM are skeletal diseases caused by changes in the bone microenvironment. As a result, patients with T2DM are at risk for higher prevalence of fragility fractures. There are a variety of treatments available for counteracting this effect. Some antidiabetic medications, such as metformin, have been shown to have a positive effect on bone health without the addition of additional drugs into patients’ treatment plans. Chinese randomised controlled trial (RCT) studies have also proposed antiosteoporotic pharmacotherapies as a viable alternative treatment strategy. Previous network meta-analyses (NMAs) and meta-analyses regarding this topic did not include all available RCT trials, or only performed pairwise comparisons. We present a protocol for a two-part NMA that incorporates all available RCT data to provide the most comprehensive ranking of antidiabetics (part I) and antiosteoporotic (part II) pharmacotherapies in terms of their ability to decrease fracture incidences, increase bone mineral density (BMD) and improve indications of bone turnover markers (BTMs) in adult patients with T2DM.Methods and analysisWe will search Medical Literature Analysis and Retrieval System Online, Excerpta Medica Database, PubMed, Web of Science, Cumulative Index to Nursing and Allied Health Literature, Cochrane Central Register of Controlled Trials and Chinese literature sources (China National Knowledge Infrastructure, Chongqing VIP Information, Wanfang Data, Wanfang Med Online) for RCTs, which fit our criteria. We will include adult patients with T2DM who have taken antidiabetics (part I) or antiosteoporotic (part II) therapies with relevant outcome measures in our study. We will perform title/abstract and full-text screening as well as data extraction in duplicate. Risk of bias will be evaluated in duplicate for each study, and the quality of evidence will be examined using Confidence in Network Meta-Analysis in accordance to the Grading of Recommendations Assessment, Development and Evaluation framework. We will use R and gemtc to perform the NMA. We will report changes in BMD and BTMs in either weighted or standardised mean difference, and we will report fracture incidences as ORs. We will use the Surface Under the Cumulative Ranking Curve scores to provide numerical estimates of the rankings of interventions.Ethics and disseminationThe study will not require ethics approval. The findings of the two-part NMA will be disseminated in peer-reviewed journals and presented at conferences. We aim to produce the most comprehensive quantitative analysis regarding the management of T2DM bone disease. Our analysis should be able to provide physicians and patients with up-to-date recommendations for antidiabetic medications and antiosteoporotic pharmacotherapies for maintaining bone health in patients with T2DM.PROSPERO registration numberCRD42019139320.

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“…Neck pain is well known as one of the most common pain problems, and the reported prevalence ranges from 22-30 % [1][2][3]. It can result in significantly reduced quality of daily life and extensive use of healthcare resources [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Stabilization Exercise for Neck Pain: A Narrative Review and Meta-Analysis of Randomized Controlled Studies

Zang¹,

Zhou²,

Liu³

et al. 2019

Phys Med Rehab Kuror

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Introduction Stabilization exercise may be an important approach to alleviate neck pain. However, its use has not been well established. We conduct a narrative review and meta-analysis to evaluate the efficacy of stabilization exercise to control neck pain. Methods PubMed, Embase, and the Cochrane Central Register of Controlled Trials are searched. Randomized controlled trials (RCTs) assessing the influence of stabilization exercise on neck pain are included. Two investigators independently have searched articles, extracted data, and assessed the quality of included studies. Meta-analysis is performed using the random-effect model. Results Five RCTs involving 217 patients are included in the meta-analysis. Compared with control intervention for neck pain, stabilization exercises has no notable impact on pain intensity (Std. MD=−0.55; 95% CI=−1.24 to 0.14; P=0.12), neck disability index (Std. MD=−0.44; 95% CI=−1.01 to 0.13; P=0.13), SF-36 physical health (Std. MD=−0.18; 95% CI=−0.61 to 0.26; P=0.43), SF-36 mental health (Std. MD=−0.03; 95% CI=−0.47 to 0.41; P=0.89), but can remarkably decrease depression scale (Std. MD=−1.05; 95% CI=−1.59 to −0.50; P=0.0002). Conclusions Stabilization exercises shows similar impact on pain intensity, neck disability index, SF-36 physical health and SF-36 mental health, but significant reduced depression scale compared with control intervention in patients with neck pain.

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Is there an association between diabetes and neck pain and lower back pain? Results of a population-based study

Cited by 26 publications

References 36 publications

Does diabetes influence the probability of experiencing chronic low back pain? A population-based cohort study: the Nord-Trøndelag Health Study

Does diabetes influence the probability of experiencing chronic low back pain? A population-based cohort study: the Nord-Trøndelag Health Study

Antidiabetic and antiosteoporotic pharmacotherapies for prevention and treatment of type 2 diabetes-induced bone disease: protocol for two network meta-analyses

Efficacy of Stabilization Exercise for Neck Pain: A Narrative Review and Meta-Analysis of Randomized Controlled Studies

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