Is there an association between autoimmunity and endometriosis?

Eisenberg, V. H.; Zolti, Mati; Soriano, David

doi:10.1016/j.autrev.2012.01.005

Cited by 139 publications

(106 citation statements)

References 115 publications

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“…As demonstrated in previous work, women with endometriosis exhibit altered or reduced innate and even adaptive immunity (Dmowski et al, 1981;Ota and Igarashi, 1993;Chiang and Hill, 1997;Khan et al, 2009). Additional studies suggest an autoimmune component to endometriosis (Eisenberg et al, 2012). Specific MHC I alleles may result in altered immune responses, leading to uncontrolled growth of stem cells, progenitor cells, and/or ectopic glandular tissue (Forte et al, 2014).…”

Section: Discussionmentioning

confidence: 60%

Spontaneous endometriosis in rhesus macaques: evidence for a genetic association with specific Mamu-A1 alleles

Kondova¹,

Braskamp²,

Heidt³

et al. 2017

Primate Biol.

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Abstract. Endometriosis is a poorly understood common debilitating women's reproductive disorder resulting from proliferative and ectopic endometrial tissue associated with variable clinical symptoms including dysmenorrhea (painful menstrual periods), dyspareunia (pain on intercourse), female infertility, and an increased risk of malignant transformation. The rhesus macaque (Macaca mulatta) develops a spontaneous endometriosis that is very similar to that seen in women. We hypothesized that specific major histocompatibility complex (MHC) alleles may contribute to the pathogenesis of endometriosis. As part of a collaboration between the Biomedical Primate Research Centre (BPRC) in the Netherlands and the New England Primate Research Center (NEPRC) in the United States, we analyzed DNA sequences of MHC class I (Macaca mulatta, Mamu-A1) and class II (Mamu-DRB) alleles from rhesus macaques with endometriosis and compared the allele frequencies with those of age-matched healthy macaques. We demonstrate that two MHC class I alleles are overrepresented in diseased macaques compared to controls: Mamu-A1*001, 33.3 % in BPRC animals with endometriosis vs. 11.6 % in healthy macaques (p = 0.007), and Mamu-A1*007, 21.9 % NEPRC rhesus macaques vs. 6.7 %, (p = 0.003). We provide evidence that select MHC class I alleles are associated with endometriosis in rhesus macaques and suggest that the disease pathogenesis contribution of MHC class I warrants further research.

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Section: Discussionmentioning

confidence: 60%

Spontaneous endometriosis in rhesus macaques: evidence for a genetic association with specific Mamu-A1 alleles

Kondova¹,

Braskamp²,

Heidt³

et al. 2017

Primate Biol.

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“…59 Autoimmune diseases that may be associated with endometriosis include systemic lupus erythematosus (SLE), hypothyroidism, rheumatoid arthritis, Sjögren syndrome, and multiple sclerosis. The best evidence exists for an association with inflammatory bowel diseases.…”

Section: Inflammation and Immunologymentioning

confidence: 99%

Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France

D’Hooghe²,

et al. 2013

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Endometriosis, defined as estrogen-dependent lesions containing endometrial glands and stroma outside the uterus, is a chronic and often painful gynecological condition that affects 6% to 10% of reproductive age women. Endometriosis has estimated annual costs of US $12 419 per woman (approximately €9579), comprising one-third of the direct health care costs with two-thirds attributed to loss of productivity. Decreased quality of life is the most important predictor of direct health care and total costs. It has been estimated that there is a mean delay of 6.7 years between onset of symptoms and a surgical diagnosis of endometriosis, and each affected woman loses on average 10.8 hours of work weekly, mainly owing to reduced effectiveness while working. To encourage and facilitate research into this debilitating disease, a consensus workshop to define future directions for endometriosis research was held as part of the 11th World Congress on Endometriosis in September 2011 in Montpellier, France. The objective of this workshop was to review and update the endometriosis research priorities consensus statement developed following the 10th World Congress on Endometriosis in 2008. 1 A total of 56 recommendations for research have been developed, grouped under 6 subheadings: (1) diagnosis, (2) classification and prognosis, (3) clinical trials, treatment, and outcomes, (4) epidemiology, (5) pathophysiology, and (6) research policy. By producing this consensus international research priorities statement, it is the hope of the workshop participants that researchers will be encouraged to develop new interdisciplinary research proposals that will attract increased funding support for work on endometriosis.

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“…It is characterized by the presence of tissue with epithelial and stromal characteristics of endometrium in extra-uterine sites [1,2]. The etiology of endometriosis has not yet been fully defined [1].…”

mentioning

confidence: 99%

“…The etiology of endometriosis has not yet been fully defined [1]. Recently, immunologic disorders have been proposed to play a pathogenesis role in endometriosis [1,2]. It has been shown that endometriosis shares similarities with several autoimmune disorders [1,2].…”

mentioning

confidence: 99%

“…Recently, immunologic disorders have been proposed to play a pathogenesis role in endometriosis [1,2]. It has been shown that endometriosis shares similarities with several autoimmune disorders [1,2]. Concordantly, It has been found that women affected by endometriosis frequently suffer from autoimmune inflammatory diseases such as systemic lupus erythematous (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS) and Hashimoto's thyroiditis (HT) [3].…”

mentioning

confidence: 99%

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