Is There any Association Between Nesfatin-1 and Generalized Anxiety Disorder?

Bahçeci, Bülent; Bağcıoğlu, Erman; Dilek, Aziz Ramazan; Celik, Fatmagul Helvaci; Bahçeci, İ̇lkay; Gönül, Yücel; Hocaoğlu, Çiçek

doi:10.5455/bcp.20130421014608

Cited by 2 publications

(5 citation statements)

References 24 publications

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“…Moreover, in a human study, plasma nesfatin-1 levels have been positively correlated to levels of anxiety in obese populations (26). However, there is some evidence to support that low nesfatin-1 levels are associated with anxiety disorders (15), whereas some studies report no relationship (16). Additionally, a study conducted on obese subjects found a sex-specific, positive correlation between plasma nesfatin-1 levels and anxiety in favor of the female population (27).…”

Section: Discussionmentioning

confidence: 96%

“…For instance, the peripheral measurement of a central acting peptide may not be sufficient to determinate its central role. As animal and clinical studies indicated that central nesfatin-1 is involved in the regulation of emotional and stress responses, results of the studies that measured peripheral nesfatin-1 levels in psychiatric conditions are confounding (9,15,16,29). In one study, the authors suggested that nutritional status can be associated with different expressions of nesfatin-1 levels in psychiatric populations (15).…”

Section: Discussionmentioning

confidence: 99%

“…In a previous study, nesfatin-1 levels were found to berelatively higher in patients diagnosed with panic disorder than in the control group (13). However, data regarding nesfatin-1 levels in patients diagnosed with generalized anxiety disorder are conflicting (15,16), and studies examining nesfatin-1 levels in subjects with affective disorders are limited. One study showed nesfatin-1 levels to be significantly higher in subjects with major depression than in the control group, whereas another study reported decreased nesfatin-1 levels during manic episodes (17,18).…”

Section: Introductionmentioning

confidence: 93%

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Plasma Nesfatin-1 Levels and its Relationship with Anxiety Levels in Obesity Diagnosed Population: A Controlled Study

Baykan

2019

Clinical and Experimental Health Sciences

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Objective: Nesfatin-1 is a satiety neuropeptide involved in the regulation of metabolic pathways and food intake. Some studies have shown nesfatin-1 to be also associated with stress responses and stress-related behaviors. In the present study, we evaluated nesfatin-1 levels in obese individuals and investigated whether nesfatin-1 levels could be associated with anxiety levels in obese populations. Methods: Fifty-eight obese (29 anxious and 29 non-anxious) patients and 25 healthy control subjects between 18 and 65 years old were enrolled in the study. Plasma nesfatin-1 levels were measured with a commercial enzyme-linked immunosorbent assay, and anxiety levels were measured using the Hospital Anxiety and Depression Scale. Results: Plasma nesfatin-1 levels were significantly lower in both obese and anxious subjects and obese and non-anxious subjects than in the control group. No significant differences were found between the obese+anxious group and the obese+nonanxious group. Conclusion:Our results suggest that plasma nesfatin-1 levels are decreased and not associated with anxiety levels in obese populations

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 93%

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Plasma Nesfatin-1 Levels and its Relationship with Anxiety Levels in Obesity Diagnosed Population: A Controlled Study

Baykan

2019

Clinical and Experimental Health Sciences

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“…[ 42 , 43 ] Nesfatin-1 might be related with the modulation of anxiety and depression. Limited data exist in the literature about the level of nesfatin-1 in patients with anxiety or depression,[ 15 , 34 , 44 , 45 ] and results from these studies are conflicting because of the marked heterogeneity of the study populations. On the other hand, this was not studied in FMS patients with anxiety and depression.…”

Section: Discussionmentioning

confidence: 99%

“…However, the relationship between nesfatin-1 and common or comorbid symptoms of FMS such as pain, sleep disturbance, anxiety, and depression has been published in the literature, each separately. 13,[31][32][33][34] In this study, serum nesfatin-1 levels of females with FMS and healthy control subjects compatible in terms of age, sex, and BMI were compared. The relationships between serum nesfatin-1 levels and demographic features and clinical parameters such as pain severity, disease activity, fatigue, emotional status, and sleep quality were evaluated in patients with FMS.…”

Section: Discussionmentioning

confidence: 99%

Is There any Association Between Low Level of Serum Nesfatin-1 and Fibromyalgia Syndrome?

et al. 2020

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Objectives This study aims to investigate the relationship between serum level of nesfatin-1 and fibromyalgia syndrome (FMS) clinical parameters such as pain severity, disease activity, fatigue, emotional state, and sleep quality. Patients and methods Forty-six female patients with FMS (median age 40 years; range, 18 to 53 years) and 46 healthy female controls (median age 36 years; range, 19 to 52 years) were included in the study. Severity of pain, disease activity, fatigue, sleep quality, and emotional status were evaluated by visual analog scale, Fibromyalgia Impact Questionnaire, Multidimensional Assessment of Fatigue (MAF), Pittsburgh Sleep Quality Index (PSQI), Beck Depression Inventory (BDI), and Beck Anxiety Inventory (BAI), respectively. Serum nesfatin-1 concentrations (pg/mL) were measured by enzyme-linked immunosorbent assay method. Results There was no significant difference with respect to demographic characteristics between the FMS patients and healthy controls. When clinical parameters were compared, MAF, BDI, BAI, and PSQI scores were significantly higher in FMS patients than controls (p<0.05). Serum nesfatin-1 concentration was significantly lower in patients with FMS (p<0.05). When compared to the FMS patients without anxiety, serum nesfatin-1 concentration was significantly increased in FMS patients with anxiety (p<0.05). Serum nesfatin-1 concentration was positively correlated with BAI scores in patients with FMS (p<0.05). Conclusion Low nesfatin-1 serum levels may contribute to pathological changes in FMS. In addition, nesfatin-1 may also be involved in the mediation of anxiety-related responses in FMS.

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Is There any Association Between Nesfatin-1 and Generalized Anxiety Disorder?

Cited by 2 publications

References 24 publications

Plasma Nesfatin-1 Levels and its Relationship with Anxiety Levels in Obesity Diagnosed Population: A Controlled Study

Plasma Nesfatin-1 Levels and its Relationship with Anxiety Levels in Obesity Diagnosed Population: A Controlled Study

Is There any Association Between Low Level of Serum Nesfatin-1 and Fibromyalgia Syndrome?

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