Is there any genetic predisposition of MMP-9 gene C1562T and MTHFR gene C677T polymorphisms with essential hypertension?

Abstract

The current study was conducted to determine whether there is a relation between hypertension and two different polymorphisms, including C1562T of the Matrix metalloproteinase-9 (MMP-9) gene and C677T of the methylenetetrahydrofolate reductase (MTHFR) gene. Genomic DNA obtained from 224 persons (125 patients with hypertension and 99 healthy controls) were used in the study. Polymorphisms were determined by using polymerase chain reaction-restriction fragment length polymorphism and electrophoresis. The results were statistically analyzed and were found to be statistically significant. The frequencies of the C1562T genotypes were found to be, in controls CC 75.8 % and CT 24.2 % and in patients CC 71.2 %, and CT 28.8 %. The frequencies of C677T genotype were found to be, in controls CC 56.6 %, CT 38.4 and TT 5.1 % in controls and in patients CC 52 %, CT 30.4 % and TT 17.6 %. In conclusion, we may suggest that there is no relation between the essential hypertension and C1562T polymorphism of MMP-9 gene; on the other hand C677T polymorphism (genotype TT) of MTHFR gene can be regarded as a genetic indicator for the development of essential hypertension.

Riboflavin status, MTHFR genotype and blood pressure: current evidence and implications for personalised nutrition

“…Generally consistent with these findings from genomewide association studies, there is a growing body of evidence from observational studies to support a specific association between the 677C T polymorphism in the MTHFR gene and BP variation (91)(92)(93)(94) . As the evidence has accumulated numerous meta-analysis were conducted, all reporting significant associations of the MTHFR 677C…”

Association of MMP-1, 9, 12 and TIMP-1 gene polymorphisms in Malaysian male hypertensive subjects

“…The results are well in line with other populations where, there was no significant difference in Northeastern Han Chinese and Turkish hypertensive subjects [15,24]. However, not in accordance with other studies done in isolated systolic hypertension among Han Chinese [33].…”

“…Several studies have been reported the association of lipid profiles in the hypertensive subjects with disagreeing results [15,33,34]. We evaluated association of clinical and biochemical characteristics with EH, which are tabulated in Table 3.…”

“…Estimation of about 30-70% of genetic heritability believed to play a key role in blood pressure regulation [13]. Recently, some studies have evaluated the association of MMP gene polymorphisms with hypertension [14,15]. Several studies have been carried out on association between MMP gene single nucleotide polymorphisms (SNPs) and Cardiovascular Disease (CVD) in many populations, with conflicting results (Table 1).…”

Association of MTHFR (C677t) and Ace (I/D) Polymorphisms With Hypertension and Response to Treatment Among Egyptian Patients

“…A numerous number of candidate genes and polymorphisms have been implicated in hypertension study as well as determinants risk factors (Agarwal, 2005). Recently, meta-analysis of wide genome association studies were done in large numbers of patients and identified various genetic loci linked not only with Blood Pressure (BP) variation (Levy et al, 2009;Newton-Cheh et al, 2009) but also in the individualization of the response to treatment (Bayramoglu et al, 2015;Fontana et al, 2015). Several studies reported the putative role of a mutation at nucleotide C677T in the methylenetetrahydrofolate reductase (MTHFR) gene (Xueqing et al, 2007).…”