Is there any relationship between serum levels of interleukin-10 and atherosclerosis in hemodialysis patients?

Seyrek, Neslihan; Karayaylalı, İbrahim; Balal, Mustafa; Paydaş, Saime; Aikimbaev, Kairgeldy; Çetiner, Salih; Seydaoğlu, Gülşah

doi:10.1080/00365590500386734

Cited by 16 publications

(12 citation statements)

References 12 publications

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“…Seyrek et al found low serum levels of IL-10 and high levels of high-sensitivity CRP in patients with atherosclerosis undergoing HD. They suggested that limitation of anti-inflammatory response in atherosclerotic uremic patients may be a triggering or contributory factor for atherosclerosis (22). Hyperhomocysteinemia in patients with CRF may accelerate oxidative stress, and lipid peroxidation may be involved in the occurrence of microinflammation state.…”

Section: Discussionmentioning

confidence: 97%

Cytokines and growth factors in mostly atherosclerotic patients on hemodialysis determined by biochip array technology

Sertić¹,

Slaviček²,

Božina³

et al. 2007

Clinical Chemical Laboratory Medicine

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Section: Discussionmentioning

confidence: 97%

Cytokines and growth factors in mostly atherosclerotic patients on hemodialysis determined by biochip array technology

Sertić¹,

Slaviček²,

Božina³

et al. 2007

Clinical Chemical Laboratory Medicine

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“…40,41 On the other hand, decreased levels of IL-10 have been described in MHD patients with carotid atherosclerotic plaques. 42 Furthermore, a genotype associated with lower IL-10 production predicts cardiovascular death in MHD patients. 43 These data support the hypothesis that ARBs may be preferable to ACE inhibitors in limiting cardiovascular events in MHD patients.…”

Section: Discussionmentioning

confidence: 99%

Comparative Effects of Angiotensin-Converting Enzyme Inhibition and Angiotensin-Receptor Blockade on Inflammation during Hemodialysis

Gamboa¹,

Pretorius²,

Todd-Tzanetos³

et al. 2012

Journal of the American Society of Nephrology

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Biomarkers of oxidative stress and inflammation predict cardiovascular events in maintenance hemodialysis patients. Angiotensin-converting enzyme (ACE) inhibitors and angiotensin-receptor blockers (ARBs) reduce cardiovascular mortality in the general population, but their benefit in maintenance hemodialysis patients is not fully explored. To test whether ACE inhibitors and ARBs differentially affect markers of oxidative stress, inflammation, and fibrinolysis during hemodialysis, we conducted a randomized, doubleblind, placebo-controlled 333 crossover study. We randomly assigned 15 participants undergoing hemodialysis to placebo, ramipril (5 mg/d), and valsartan (160 mg/d) for 7 days, with a washout period of 3 weeks in between the treatments. On the morning of the seventh day of drug treatment, participants underwent serial blood sampling during hemodialysis. Neither ramipril nor valsartan affected BP during hemodialysis. Ramipril increased IL-1b concentrations (P=0.02) and decreased IL-10 concentrations (P=0.04) compared with placebo. Valsartan and ramipril both lowered IL-6 levels during dialysis (P,0.01 for each compared with placebo). Valsartan increased F 2 -isoprostane levels, and ramipril suggested a similar trend (P=0.09). Valsartan and ramipril both lowered D-dimer levels (P,0.01 for both), whereas only ramipril seemed to prevent a rise in vWf levels (P=0.04). In summary, during hemodialysis, valsartan induces a greater anti-inflammatory effect compared with ramipril, although ramipril seems to prevent dialysis-induced endothelial dysfunction as measured by levels of vWf. A prospective clinical trial is necessary to determine whether ACE inhibitors and ARBs also differ with respect to their effects on cardiovascular mortality in this population. 23: 334-342, 201223: 334-342, . doi: 10.1681 In ESRD patients, cardiovascular death accounts for .50% of overall mortality and the risk of cardiovascular death is 30 times higher than in the general population. 1,2 Moreover, patients undergoing maintenance hemodialysis (MHD) have a 5-year survival rate of 10% after acute myocardial infarction. 3 Traditional risk factors, as used in Framingham risk scoring, only explain half of the excessive cardiovascular mortality observed in ESRD patients, 4 and it is thought that other factors contribute to the high cardiovascular mortality among ESRD patients. J Am Soc NephrolIncreased oxidative stress and inflammation may contribute to accelerated atherosclerosis and cardiovascular events in patients with MHD. 5,6 Markers of oxidative stress, such as F 2 -isoprostanes, are increased in MHD patients. 7,8 Inflammatory markers, particularly IL-1, IL 6, and TNFa, are also elevated in MHD patients and are associated with

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“…33,62,63 Plasma levels of IL-10, one of the most important anti-inflammatory immune-regulating cytokines, 64 are usually elevated in CKD because of persistent underlying inflammation. 44,56,58 Hemodialysis patients with lower plasma IL-10 levels seem to be at greater risk for atherosclerosis, 65 whereas those patients genetically predisposed to produce higher IL-10 levels show better immune balance 66 and are at lower risk of cardiovascular events. 67 It can be argued that the balance between IL-6 and IL-10 is a more valid parameter to draw conclusions about the overall inflammatory status.…”

Section: Effects Of Regular Exercisementioning

confidence: 99%

Evidence for Anti-Inflammatory Effects of Exercise in CKD

Viana

Kosmadakis

Watson

et al. 2014

Journal of the American Society of Nephrology

160

128

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CKD is associated with a complex state of immune dysfunction characterized by immune depression, predisposing patients to infections, and immune activation, resulting in inflammation that associates with higher risk of cardiovascular disease. Physical exercise may enhance immune function and exert antiinflammatory effects, but such effects are unclear in CKD. We investigated the separate effects of acute and regular moderate-intensity aerobic exercise on neutrophil degranulation (elastase release), activation of T lymphocytes (CD69 expression) and monocytes (CD86 and HLA-DR expression), and plasma inflammatory markers (IL-6, IL-10, soluble TNF-receptors, and C-reactive protein) in patients with predialysis CKD. A single 30-minute (acute) bout of walking induced a normal pattern of leukocyte mobilization and had no effect on T-lymphocyte and monocyte activation but improved neutrophil responsiveness to a bacterial challenge in the postexercise period. Furthermore, acute exercise induced a systemic anti-inflammatory environment, evidenced by a marked increase in plasma IL-10 levels (peaked at 1 hour postexercise), that was most likely mediated by increased plasma IL-6 levels (peaked immediately postexercise). Six months of regular walking exercise (30 min/d for 5 times/wk) exerted anti-inflammatory effects (reduction in the ratio of plasma IL-6 to IL-10 levels) and a downregulation of T-lymphocyte and monocyte activation, but it had no effect on circulating immune cell numbers or neutrophil degranulation responses. Renal function, proteinuria, and BP were also unaffected. These findings provide compelling evidence that walking exercise is safe with regard to immune and inflammatory responses and has the potential to be an effective anti-inflammatory therapy in predialysis CKD.

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Is there any relationship between serum levels of interleukin-10 and atherosclerosis in hemodialysis patients?

Abstract: Patients with AS undergoing HD had low serum levels of the anti-inflammatory cytokine IL-10 and high serum levels of hs-CRP. These results may suggest that limitation of the anti-inflammatory response in atherosclerotic uremic patients is a triggering or contributory factor for AS.

Cited by 16 publications

References 12 publications

Cytokines and growth factors in mostly atherosclerotic patients on hemodialysis determined by biochip array technology

Cytokines and growth factors in mostly atherosclerotic patients on hemodialysis determined by biochip array technology

Comparative Effects of Angiotensin-Converting Enzyme Inhibition and Angiotensin-Receptor Blockade on Inflammation during Hemodialysis

Evidence for Anti-Inflammatory Effects of Exercise in CKD

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