Is There Any Relationship between Metabolic Parameters and Left Ventricular Functions in Type 2 Diabetic Patients without Evident Heart Disease?

Abstract

Diastolic LV dysfunction may develop even in absence of ischemia, hypertension, and LVH in T2DM. FBG and PPG have no effect on LV functions, but HbA(1C) levels may affect diastolic parameters.

Cumulative Impact of Cardiovascular Risk Factors on Regional Left Ventricular Function and Reserve: Progressive Long-Axis Dysfunction with Compensatory Radial Changes

“…Deformation imaging would be necessary only to localize dysfunction to particular myocardial segments. Other investigators who have reported reduced longitudinal function in patients with risk factors have found similar results for either strain/strain rate or velocities 25–28 . Moreover, recent data comparing strain, by either speckle tracking or tissue Doppler, with tagged harmonic‐phase magnetic resonance imaging showed only modest correlations (r = 0.40–0.60), thus reflecting the technical challenges of these techniques 29 …”

Can ambulatory blood pressure monitoring detect early diastolic dysfunction in children with type 1 diabetes mellitus: correlations with B-type natriuretic peptide and tissue Doppler findings

“…In diabetic hypertensive patients, concentric and eccentric left ventricular hypertrophy, increase in left ventricular muscle mass have been documented . In DM, the relationship between ABPM measurements and target organ damage has been showed in studies performed especially in adults . In this study, we planned to examine the relationship between elevated BP in diabetic children and early cardiac dysfunction.…”

The relationship between early left ventricular myocardial alterations and reduced coronary flow reserve in non-insulin-dependent diabetic patients with microvascular angina

“…Although subclinical LV dysfunction is present in very early stages in type 2 diabetic patients, there are few studies evaluating the relationship of LV dysfunction with HbA1C and blood glucose levels [26][27][28]. Most of these studies were done with conventional echocardiographic method and in some of them important parameters such as hypertension and coronary artery disease were not taken into consideration.…”