Is There Still a Role for Radiation Therapy in the Management of Benign Disease?

Fionda, Bruno; Rembielak, A.

doi:10.1016/j.clon.2022.09.051

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…There is, however, emerging evidence encouraging the use of radiotherapy in schwannomas of other cranial nerves (III, IV, V and VI) in non-surgical candidates, resulting in the local control rate ranging from 90 to 100% [ 56 , 57 ].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic and Therapeutic Strategy for Vagal Schwannoma: Case Series and Literature Review

et al. 2023

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Background and Objectives: Clinical management of vagal schwannoma is a real diagnostic and therapeutic challenge because the medical history and clinical examination are often non-specific and vagal nerve injury following surgical resection still represents an unsolved problem. The aim of this paper is to provide a case series along with a diagnostic and therapeutic algorithm for vagal schwannoma of the head and neck, combining our experience with clinical evidence available in the literature. Materials and Methods: We retrospectively analyzed a series of patients affected by vagal schwannoma who were treated between 2000 and 2020. In addition, a review of the literature on vagal schwannoma management was conducted. Based on the cases described and the literature review, we made a diagnostic and therapeutic algorithm for the management of vagal schwannoma. Results: We were able to identify 10 patients affected by vagal schwannoma and treated between 2000 and 2020. All patients presented with a painless, mobile, slow-growing lateral neck mass with onset varying from a few months to years. The preoperative diagnostic workup included ultrasound (US) in nine cases, computed tomography (CT) with contrast in six patients and magnetic resonance imaging (MRI) of the neck in seven cases. All patients included in this study were surgically treated. Conclusions: Vagal schwannoma management represents a true challenge for clinicians and surgery is currently the most effective therapeutic strategy. A multidisciplinary approach through the collaboration of otolaryngologist with other specialists is desirable to develop a tailored treatment plan for the patient.

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Section: Discussionmentioning

confidence: 99%

Diagnostic and Therapeutic Strategy for Vagal Schwannoma: Case Series and Literature Review

et al. 2023

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“…Radiation therapy for benign diseases is not a new method and has become a useful treatment modality since the discovery of radiation more than a century ago [20]. Brachytherapy has been acknowledged as a therapeutic alternative for cystic CPs, tracing back to its initial documentation seven decades prior.…”

Section: Introductionmentioning

confidence: 99%

Brachytherapy in craniopharyngiomas: a systematic review and meta-analysis of long-term follow-up

Zhang,

Guo,

et al. 2024

BMC Cancer

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Objective Brachytherapy has been indicated as an alternative option for treating cystic craniopharyngiomas (CPs). The potential benefits of brachytherapy for CPs have not yet been clarified. The purpose of this work was to conduct a meta-analysis to analyze the long-term efficacy and adverse reactions profile of brachytherapy for CPs. Materials and methods The relevant databases were searched to collect the clinical trials on brachytherapy in patients with CPs. Included studies were limited to publications in full manuscript form with at least 5-year median follow-up, and adequate reporting of treatment outcomes and adverse reactions data. Stata 12.0 was used for data analysis. Results According to the inclusion and exclusion criteria, a total of 6 clinical trials involving 266 patients with CPs were included in this meta-analysis. The minimum average follow-up was 5 years. The results of the meta-analysis showed that 1-year, 2–3 years and 5 years progression free survival rates (PFS) are 75% (95%CI: 66-84%), 62% (95%CI: 52-72%) and 57% (95%CI: 22-92%), respectively. At the last follow-up, less than 16% of patients with visual outcomes worser than baseline in all included studies. While, for endocrine outcomes, less than 32% of patients worser than baseline level. Conclusion In general, based on the above results, brachytherapy should be considered as a good choice for the treatment of CP.

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Is There Still a Role for Radiation Therapy in the Management of Benign Disease?

Cited by 2 publications

References 11 publications

Diagnostic and Therapeutic Strategy for Vagal Schwannoma: Case Series and Literature Review

Diagnostic and Therapeutic Strategy for Vagal Schwannoma: Case Series and Literature Review

Brachytherapy in craniopharyngiomas: a systematic review and meta-analysis of long-term follow-up

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