ISCEV standard for clinical multifocal electroretinography (mfERG) (2011 edition)

Hood, Donald C.; Bach, Michael; Brigell, Mitchell; Keating, David; Kondo, Mineo; Lyons, Jonathan S.; Marmor, Michael F.; McCulloch, Daphne L.; Palmowski-Wolfe, Anja

doi:10.1007/s10633-011-9296-8

Cited by 533 publications

(358 citation statements)

References 7 publications

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“…10 Normative EOG data were obtained by testing 30 individuals aged between 30 and 60 years of age with no known ocular abnormalities. One eye from each normal subject was randomly selected and used to establish the normative data.…”

Section: Methodsmentioning

confidence: 99%

Normal Electrooculography in Best Disease and Autosomal Recessive Bestrophinopathy

Khan

Islam

Holder

et al. 2018

Retina

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SUMMARY STATEMENTThe Bestrophinopathies are a group of inherited eye disorders that arise from either dominant or recessive mutations in the BEST1 gene. Electrooculography is invaluable in the diagnosis of Best disease (BD) and autosomal recessive bestrophinopathy (ARB), as a reduced Arden ratio is a highly penetrant feature of disease. We demonstrate that EOG phenotype in BD and ARB is more variable than currently appreciated. Conclusions:The current work provides significant clinical evidence that the EOG phenotype in BD and ARB is more variable than currently appreciated. As a normal EOG may occur in the presence of a classical fundus appearance, the consequences of BEST1 mutation may be independently expressed, possibly mediated via differential effects on intracellular calcium homeostasis.4

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Section: Methodsmentioning

confidence: 99%

Normal Electrooculography in Best Disease and Autosomal Recessive Bestrophinopathy

Khan

Islam

Holder

et al. 2018

Retina

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“…Electrophysiological examinations were conducted at Kennedy Centre, Denmark according to the standards given by International Society of Clinical Electrophysiology in Vision, [14][15][16] with one exception: Dawson-Trick-Litzkow 17 electrodes were used instead of Burian-Allen contact lens electrodes because of contact lens intolerance in the index case and the choice of using the same method in all family members. For both electrooculography and full-field electroretinography, we used a Viking 5.0 Ganzfeld dome (Nicolet Biomedical Instruments, Madison, Wisconsin), with a light-emitting diode for light stimulation.…”

Section: Clinical Investigationsmentioning

confidence: 99%

Ocular Phenotype Analysis of a Family With Biallelic Mutations in the BEST1 Gene

Sharon

Al-Hamdani

Engelsberg³

et al. 2014

American Journal of Ophthalmology

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“…The average of the data from each region was obtained. All electrophysiological procedures were performed according to the guidelines of the International Society for Clinical Electrophysiology of Vision (ISCEV) (11) . A sex-and age-matched control group of 21 eyes was also evaluated using OCT and mfERG.…”

Section: Methodsmentioning

confidence: 99%

Optical coherence tomography and multifocal electroretinography of patients with advanced neovascular age-related macular degeneration before, during, and after treatment with ranibizumab

Almeida¹,

Almeida

Sobrinho

et al. 2015

Arquivos Brasileiros De Oftalmologia

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Purpose: To evaluate retinal morphology and function of patients with advanced neovascular age-related macular degeneration (AMD) before, during, and after treatment with ranibizumab. Methods: Twenty-one eyes diagnosed with advanced AMD were studied with optical coherence tomography (OCT) and multifocal electroretinography (mfERG). Three intravitreal injections of ranibizumab were administered at 1-month intervals. Evaluations were performed before the first injection (D0) and at 30 (D30), 60 (D60), and 90 days (D90) after the first injection and compared to an age-matched control group (n=21 eyes). Results: The thickness of macular retinal layers increased before treatment due to the presence of intraretinal fluid. A thick retinal pigment epithelium-choriocapillaris complex (RPE-CC) suggested the presence of choroidal neovascular membrane. Intraretinal edema decreased after treatment (P<0.01), but persisting RPE-CC thickness resulted in a subretinal scar. Three different annular retinal areas were studied with mfERG (from center to periphery: rings R1, R2, and R3). The amplitude of the first negative component (N1) decreased in R1, R2, and R3 at D30, D60, and D90 when compared with that in controls (P<0.05); the N1 implicit time was delayed in R3 at D30 (P<0.05). The amplitude of the first positive component (P1) was reduced in R1 and R2 at D30, D60, and D90 when compared with that in controls (P<0.01); the P1 implicit time was delayed in R1 at D0 and D60 (P<0.05), in R2 at D0, D30, and D90 (P<0.01), and in R3 at D30 and D60 (P<0.05). Conclusion: Ranibizumab reduces intraretinal edema, even in advanced cases. Central macular activity appeared to increase after the initiation of treatment, improving over time.Keywords: Macular degeneration/drug therapy; Antibodies; monoclonal, huma nized/therapeutic use; Tomography; optical coherence; Electroretinography; In travitreal injections RESUMO Objetivo: Avaliar a morfologia e função da retina em pacientes com doença macular relacionada à idade (DMRI), neovascular avançada, antes, durante e após o tratamento com ranibizumabe. Métodos: Vinte e um olhos com diagnóstico de DMRI avançada foram avaliados pela tomografia de coerência óptica (OCT) e eletrorretinografia multifocal (mfERG). Três injeções intravítreas de ranibizumabe foram administradas em intervalos de 1 mês. As avaliações foram realizadas antes da primeira injeção (D0) e aos 30 (D30), 60 (D60), e 90 dias (D90) após a primeira injeção e comparados com um grupo controle (n=21 olhos). Resultados: A espessura macular estava aumentada antes do tratamento devido à presença de fluido intrarretiniano, e o aumento da espessura do complexo EPR-CC foi compatível com a presença de membrana neovascular coroidal. O edema intrarretiniano diminuiu após o tratamento (P<0,01

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ISCEV standard for clinical multifocal electroretinography (mfERG) (2011 edition)

Cited by 533 publications

References 7 publications

Normal Electrooculography in Best Disease and Autosomal Recessive Bestrophinopathy

Normal Electrooculography in Best Disease and Autosomal Recessive Bestrophinopathy

Ocular Phenotype Analysis of a Family With Biallelic Mutations in the BEST1 Gene

Optical coherence tomography and multifocal electroretinography of patients with advanced neovascular age-related macular degeneration before, during, and after treatment with ranibizumab

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