Ischemia-Modified Albumin: Could It Be a New Oxidative Stress Biomarker for Colorectal Carcinoma?

Abstract

Background/AimsAn impaired oxidative/antioxidative status plays an important role in the pathogenesis of many diseases, including cancer. The aim of this study was to evaluate the levels of the novel marker ischemia-modified albumin (IMA) and albumin-adjusted IMA (Adj-IMA) in patients with colorectal cancer (CRC) and look for the associations of these with the total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI).MethodsForty patients with CRC (19 females and 21 males; mean age, 56.5±2.1 years) and 39 age- and sex-matched healthy people (22 females and 17 males; mean age, 56.0±1.7 years) were included in this study. Serum levels of IMA, TAS, and TOS were analyzed, and the OSI was calculated.ResultsSerum IMA, TOS, and OSI levels were significantly higher in patients with CRC than in controls (p<0.0001), whereas TAS levels were significantly lower in CRC patients (p=0.03). There was no significant difference in serum Adj-IMA levels between groups (p=0.32).ConclusionsIn this study, the oxidative/antioxidant status was impaired in favor of oxidative stress in CRC patients. This observation was not confirmed by IMA measurement. Further studies are needed to establish the relationship between IMA and oxidative stress parameters in CRC and other cancers.

A New Marker for Ischemia: Ischemia-modified Albumin

“…İkincisi = (bireysel albumin konsantrasyonu/popülasyonun medyan albumin konsantrasyonu) x İMA (4) . Albuminde 1 g/dL'lik bir değişiklik İMA seviyesinde %2.6 oranında bir değişikliğe yol açmaktadır (10) .…”

“…İMA gastrik, prostat, yumuşak doku kanserleri ve nöroblastomlarda artmıştır. Fidan ve arkadaş-larının mide kanserli hastalarda, Stachowicz-Stencel ve arkadaşlarının nöroblastoma ve sarkomalı çocuklarda, Ellidag ve arkadaşlarının mesane kanserli ve kolorektal kanserli hastalarda yaptıkları çalışmalarında İMA'nın artmış olduğu gösteril-di (10,(45)(46)(47) .…”

Ischemic Modified Albumin (IMA) as a Novel Marker for Ischemic Heart Disease and Surrogate Marker for Other High Oxidative -Ischemic Conditions

“…17 This is positive in a variety of conditions giving rise to tissue ischemia. 18,19 Our study highlights the importance of evaluating patient populations for testing as more false positive elevations in ischemia modified al-(STEMI) was diagnosed if there was ST segment elevation >0.1mv in 2 or more contiguous leads with cardiac troponin (cTnT) >0.05ng/ml; non-ST-segment elevation myocardial infarction (NSTEMI) was diagnosed if EKG did not show ST-segment elevation and troponin (cTnT) was >0.05ng/ml. Patients were classified as atypical chest pain when i) a non-cardiac mechanism was confirmed as the cause of chest pain ii) troponin (cTnT) results were negative on serial sampling ( three samples six hours apart) iii) neither Electrocardiogram (EKG) changes nor evidence of coronary artery disease were present.…”

Ischemia modified albumin levels in vitamin D deficiency

“…The results were expressed in absorbance units (ABSU). The intra-assay CV for 2 different levels (mean±SD: 0.484±0.006 and 0.647±0.006) was 1.23% and 0.92%, respectively [15]. IBM SPSS Statistics for Windows, Version 20.0 (IBM Corp., Armonk, NY, USA) was used for all statistical analyses.…”