Ischemic preconditioning attenuates remote pulmonary inflammatory infiltration of diabetic rats with an intestinal and hepatic ischemia-reperfusion injury

Neto, Farid José Thomaz; Koike, Márcia Kiyomi; Abrahão, Marcos de Souza; Neto, Francisco Carillo; Pereira, Renan Kenji Hanada; Machado, José Lúcio Martins; Montero, Edna Frasson de Souza

doi:10.1590/s0102-86502013000300003

Cited by 16 publications

(14 citation statements)

References 22 publications

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“…Inflammatory answer is an important factor to the exacerbation of I/R injury and uncontrolled inflammation and advanced tissue damage [ 44 ]. I/R injury induces to the translocation of toxins and bacteria, leading to systemic inflammation and in the occurrence of MODS and SIRS.…”

Section: Discussionmentioning

confidence: 99%

Consumption of Anacardium occidentale L. (Cashew Nuts) Inhibits Oxidative Stress through Modulation of the Nrf2/HO−1 and NF-kB Pathways

et al. 2020

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Ischemia/reperfusion injury is a severe disorder associated with a high mortality. Several antioxidant and pharmacological properties of cashew nuts (Anacardium occidentale L.) and its metabolites from different countries have recently been described. It is a medicinal plant with important therapeutic effects. This study aimed to verify the effect of an oral administration of cashew nuts in a rat model of ischemia/reperfusion (I/R). Adult male rats were subjected to intestinal I/R injury by clamping the superior mesenteric artery for 30 min and then allowing animals to 1 h of reperfusion. Rats subjected to I/R of the gut showed a significant increase in different biochemical markers. In particular, we evaluated lipid peroxidation, tissue myeloperoxidase activity, protein carbonyl content, reactive oxygen species generation and decreased antioxidant enzyme activities. Western blot analysis showed the activation of the NRF2 and NF-kB pathways. Increased immunoreactivity to nitrotyrosine, PARP, P-selectin, and ICAM-1 was observed in the ileum of rats subjected to I/R. Administration of cashew nuts (100 mg/kg) significantly reduced the mortality rate, the fall in arterial blood pressure, and oxidative stress and restored the antioxidant enzyme activities by a mechanism involving both NRF2 and NF-kB pathways. Cashew nuts treatments reduced cytokines plasma levels, nitrotyrosine, and PARP expression as well as adhesion molecules expressions. Additionally, cashew nuts decreased the intestinal barrier dysfunction and mucosal damage, the translocation of toxins and bacteria, which leads to systemic inflammation and associated organs injuries in particular of liver and kidney. Our study demonstrates that cashew nuts administration exerts antioxidant and pharmacological protective effects in superior mesenteric artery occlusion–reperfusion shock.

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Section: Discussionmentioning

confidence: 99%

Consumption of Anacardium occidentale L. (Cashew Nuts) Inhibits Oxidative Stress through Modulation of the Nrf2/HO−1 and NF-kB Pathways

et al. 2020

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“…Inflammation is another important contributor to the exacerbation of IRI 18 , and we detected IL-6 and TNF-α as markers of the inflammatory response 20 . The role of montelukast to reduce IL-6 and TNF-α has not been previously reported in intestinal IRI.…”

Section: Discussionmentioning

confidence: 74%

“…Intestinal IRI is a troublesome clinical disease with a high mortality rate, despite surgical intervention 17 . Ischemia and reperfusion injury has different pathophysiological features with the major mucosal injury happening during the reperfusion phase 18 19 . Thus, using pharmacological agents is an important strategy for preventing intestinal ischemic injury during intestinal IRI 19 20 21 22 23 .…”

Section: Discussionmentioning

confidence: 99%

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The protective role of montelukast against intestinal ischemia-reperfusion injury in rats

Zhu

Jin

et al. 2015

Sci Rep

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Several drugs are effective in attenuating intestinal ischemia-reperfusion injury (IRI); however little is known about the effect of montelukast. Fifty rats were randomly assigned to 3 groups: model group (operation with clamping), sham group (operation without clamping), and study group (operation with clamping and 0.2, 2 and 20 mg/kg montelukast pretreatment). Intestinal ischemia-reperfusion was performed by occlusion (clamping) of the arteria mesenterica anterior for 45 min, followed by 24 h reperfusion. Intestinal IRI in the model group led to severe damage of the intestinal mucosa, liver and kidney. The Chiu scores of the intestines from the study group (2 and 20 mg/kg) were lower than that of the model group. Intestinal IRI induced a marked increase in CysLTR1, Caspase-8 and -9 expression in intestine, liver and kidney, which were markedly reduced by preconditioning with 2 mg/kg montelukast. Preconditioning with 2 g/kg montelukast significantly attenuated hepatic tissue injury and kidney damage, and decreased plasma interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels in plasma after intestinal IRI. In conclusion, preconditioning with montelukast could attenuate intestinal IRI and the subsequent systemic inflammatory response in rats.

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“…Thomaz Neto et al [ 21 ] had already shown that the mesenteric I/R process causes mild lung injury, and that this can be minimized by ischemic preconditioning. However, this method of prevention has limited clinical applicability, since the identifying mesenteric ischemia no further opportunity for their use.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of pulmonary reperfusion injury in rats subjected to mesenteric ischemia and reperfusion and protective effect of postconditioning on this process

Santos

Aydos

Neto

et al. 2015

Revista Brasileira De Cirurgia Cardiovascular

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INTRODUCTION Some publications have demonstrated the presence of lung reperfusion injury in mesenteric ischemia and reperfusion (I/R), but under to diverse methods. Postconditioning has been recognized as effective in preventing reperfusion injury in various organs and tissues. However, its effectiveness has not been evaluated in the prevention of lung reperfusion injury after mesenteric ischemia and reperfusion.OBJECTIVE To evaluate the presence of pulmonary reperfusion injury and the protective effect of ischemic postconditioning on lung parenchyma in rats submitted to mesenteric ischemia and reperfusion.METHODS Thirty Wistar rats were distributed into three groups: group A (10 rats), which was held mesenteric ischemia (30 minutes) and reperfusion (60 minutes); group B (10 rats), ischemia and reperfusion, interspersed by postconditioning with two alternating cycles of reperfusion and reocclusion, for two minutes each; and group C (10 rats), ischemia and reperfusion interleaved by postconditioning with four alternating cycles of reperfusion and reocclusion of 30 seconds each. Finally, it was resected the upper lung lobe for histological analysis.RESULTS There were mild lung lesions (grade 1) in all samples. There was no statistical difference between groups 1 and 2 (P>0.05).CONCLUSION The mesenteric ischemia and reperfusion in rats for thirty and sixty minutes, respectively, caused mild reperfusion injury in lung. Postconditioning was not able to minimize the remote reperfusion injury and there was no difference comparing two cycles of two minutes with four cycles of 30 seconds.

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Ischemic preconditioning attenuates remote pulmonary inflammatory infiltration of diabetic rats with an intestinal and hepatic ischemia-reperfusion injury

Cited by 16 publications

References 22 publications

Consumption of Anacardium occidentale L. (Cashew Nuts) Inhibits Oxidative Stress through Modulation of the Nrf2/HO−1 and NF-kB Pathways

Consumption of Anacardium occidentale L. (Cashew Nuts) Inhibits Oxidative Stress through Modulation of the Nrf2/HO−1 and NF-kB Pathways

The protective role of montelukast against intestinal ischemia-reperfusion injury in rats

Evaluation of pulmonary reperfusion injury in rats subjected to mesenteric ischemia and reperfusion and protective effect of postconditioning on this process

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