Ischemic Preconditioning Improves Rat Kidney Allograft Function After Ischemia/Reperfusion Injury: The Role of Tumor Necrosis Factor-Alpha

Jia, Ru; Xie, Jun; Luo, Fuwen; Zhu, Jun

doi:10.1016/j.transproceed.2008.06.113

Cited by 15 publications

(12 citation statements)

References 16 publications

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“…Jia et al reported the improvement of kidney allograft function by ischemic pre-conditioning which was associated by decreased TNF-a expression. 20 In another study, ischemic conditioning caused a marked decrease in the TNF-a concentration in hepatic homogenates after 1 h of reperfusion which persisted during further phases of reperfusion (6 and 72 h). 21 In 2013, Czigany et al reported the protective effects of RPEC on liver morphology, redox homeostasis, and microcirculation.…”

Section: 10mentioning

confidence: 93%

Hind limb perconditioning renoprotection by modulation of inflammatory cytokines after renal ischemia/reperfusion

et al. 2016

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Purpose Renal ischemia/reperfusion (I/R) injury is a common clinical problem associated with significant mortality and morbidity. One newly described strategy to reduce this damage is remote perconditioning (RPEC), in which short-time ischemia of a limb during renal ischemia reduces the I/ R-induced kidney injury. This study aimed to assess whether RPEC confer protection through changes in pro-inflammatory mediators. Methods Rats were subjected to right nephrectomy and randomized into: sham (no intervention), I/R (subjected to 45-min left renal ischemia) and RPEC group (subjected to four cycles of 5-min I/R of the femoral artery administered during renal ischemia). After 24-h, blood, urine, and kidney samples were collected. Biochemical indicators of renal dysfunction were measured in the cases of Neutrophil gelatinase-associated lipocalin (NGAL), and N-acetyl-B-diglucosaminidase (NAG) activity. Inflammatory cytokines [interleukin (IL)-6 and tumor necrosis factor-alpha, TNF-a] expression in the renal tissues as well as Periodic acid-Schiff stained histological sections were evaluated. Results I/R resulted in renal dysfunction, as evidenced by higher renal NGAL expression and urinary NAG activities. This was accompanied by increased TNF-a and IL-6 expressions as well as histological changes in this group. However, RPEC improved renal histology and function compared with the I/R group. Furthermore, the RPEC group showed decreases in TNF-a and IL-6 expression. Conclusions These results suggest that RPEC reduces the dysfunction and injury associated with I/R of the kidney. This technique reduced the proinflammatory cytokine in the kidney. RPEC could be a promising strategy against I/R-induced acute kidney injury partly by down-regulation of inflammatory mediators. ARTICLE HISTORY

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Section: 10mentioning

confidence: 93%

Hind limb perconditioning renoprotection by modulation of inflammatory cytokines after renal ischemia/reperfusion

et al. 2016

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“…6 -8 Our previous studies have shown that IPC protects the kidney from renal I/R injury through inhibition of tumor necrosis factor (TNF)-alpha and its feedback signaling on NF-B pathways, but the mechanism remains unclear, especially with respect to late IPC. 9,10 Interestingly, recent investigations have observed that after IPC endothelial progenitor cells (EPCs) mobilize to ischemic organs. 11,12 Mobilization of EPCs from their niches may be due to ischemic stress generating specific cell factors.…”

mentioning

confidence: 99%

Effects of Ischemic Preconditioning in the Late Phase on Homing of Endothelial Progenitor Cells in Renal Ischemia/Reperfusion Injury

Chen

Jia

et al. 2013

Transplantation Proceedings

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“…Remote IPC is one potential approach to protect kidneys from ischemia‐reperfusion injury. Although the underlying mechanism needs to be fully defined , the concept of IPC was shown to be beneficial in rodent models of kidney transplantation , but large animal models failed to confirm these results . Furthermore, remote IPC by occluding the thigh (three times for 5 min, either in donors or recipients) failed to improve renal function within 72 h after human living donor transplantation .…”

Section: Preclinical and Experimental Donor Treatment Strategiesmentioning

confidence: 99%

Optimized donor management and organ preservation before kidney transplantation

et al. 2015

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SUMMARYKidney transplantation is a major medical improvement for patients with end-stage renal disease, but organ shortage limits its widespread use. As a consequence, the proportion of grafts procured from extended criteria donors (ECD) has increased considerably, but this comes along with increased rates of delayed graft function (DGF) and a higher incidence of immune-mediated rejection that limits organ and patient survival. Furthermore, most grafts are derived from brain dead organ donors, but the unphysiological state of brain death is associated with significant metabolic, hemodynamic, and pro-inflammatory changes, which further compromise patient and graft survival. Thus, donor interventions to preserve graft quality are fundamental to improve long-term transplantation outcome, but interventions must not harm other potentially transplantable grafts. Several donor pretreatment strategies have provided encouraging results in animal models, but evidence from human studies is sparse, as most clinical evidence is derived from single-center or nonrandomized trials. Furthermore, ethical matters have to be considered especially concerning consent from donors, donor families, and transplant recipients to research in the field of donor treatment. This review provides an overview of clinically proven and promising preclinical strategies of donor treatment to optimize long-term results after kidney transplantation. Transplant International 2016; 29: 974-984

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Ischemic Preconditioning Improves Rat Kidney Allograft Function After Ischemia/Reperfusion Injury: The Role of Tumor Necrosis Factor-Alpha

Cited by 15 publications

References 16 publications

Hind limb perconditioning renoprotection by modulation of inflammatory cytokines after renal ischemia/reperfusion

Hind limb perconditioning renoprotection by modulation of inflammatory cytokines after renal ischemia/reperfusion

Effects of Ischemic Preconditioning in the Late Phase on Homing of Endothelial Progenitor Cells in Renal Ischemia/Reperfusion Injury

Optimized donor management and organ preservation before kidney transplantation

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