Ischemic Stroke and Genetic Variants: In Search of Association with Severity and Recurrence in a Brazilian Population

Silva, Caroline Figueiredo da; Schwartz, Julia; Belli, Vitoria da Silva; Ferreira, Leslie Ecker; Cabral, Norberto Luiz; França, Paulo Henrique Condeixa de

doi:10.1016/j.jstrokecerebrovasdis.2019.104487

Cited by 5 publications

(2 citation statements)

References 26 publications

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“…However, conflicting findings suggest that rs966221 and IS risk are not significantly correlated in the Chinese population [21]. Besides the Chinese population, there is still no consensus on the question of whether rs966221 is related to susceptibility to IS [22]. Yoon et al conducted a meta-analysis and did not find a link between rs966221 and the IS risk in the overall population [23], whereas the team of Yan obtained the opposite conclusion in the overall population [24].…”

Section: Introductionmentioning

confidence: 99%

Association between PDE4D rs966221 and the Risk of Ischemic Stroke in Regional Chinese Populations

Wang

Zhang

et al. 2023

Brain Sciences

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In published research that includes genome-wide association studies and meta-analyses, the phosphodiesterase 4D (PDE4D) rs966221 variant has been identified as a risk factor in ischemic stroke (IS) in the Caucasian population. Several studies have investigated the relationship between rs966221 and IS susceptibility in Chinese populations over the years but have not provided consistently conclusive results. Therefore, our team performed a new meta-analysis of 5973 IS patients and 6204 controls from qualified studies. We observed no significant link between the PDE4D rs966221 variant and IS in any of the regional Chinese populations. Thus, we performed a subgroup analysis by the geographical distribution of China. Notably, significant associations were observed between rs96622 and the susceptibility of IS in the Northeast Chinese populations (p = 1.00 × 10−4, odds ratio = 1.28, and 95% confidence interval = 1.13–1.44, I2 = 0%). However, rs966221 was not found to be correlated with IS risk in the populations of North, Central, South, and East China. Our meta-analysis demonstrated that the PDE4D rs966221 variant is significantly associated with IS risk in some regional Chinese populations.

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Section: Introductionmentioning

confidence: 99%

Association between PDE4D rs966221 and the Risk of Ischemic Stroke in Regional Chinese Populations

Wang

Zhang

et al. 2023

Brain Sciences

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“…Poor self-health management ability [high systolic blood pressure (SBP), high blood lipid cholesterol, irregular administration of medications, smoking, alcoholism, and lack of exercise] has become an important factor for its recurrence (3)(4)(5)(6). The reason why stroke recurrence is not Original Article A randomized controlled trial of brain and heart health manager-led mHealth secondary stroke prevention uncommon is that its risk factors always exist as long as one stroke episode has occurred (7).…”

Section: Introductionmentioning

confidence: 99%

A randomized controlled trial of brain and heart health manager-led mHealth secondary stroke prevention

Wang¹,

Liu²,

Tian³

et al. 2020

Cardiovasc Diagn Ther

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Background: This study explores the effect of brain and heart health manager (BHHM)-led stroke secondary prevention on blood pressure, and in improving the self-management ability of stroke patients.The BHHM has not been reported.Methods: A total of 200 stroke patients, who were discharged from our hospital, were randomized into two groups at a 1:1 ratio: intervention group and control group. Patients in the control group were followed up for six months via telephone, while patients in the experimental group were followed up for six months using the BHHM-led mHealth follow-up. The primary outcomes were systolic blood pressure (BP) and selfmanagement ability at 3, 6, 9 and 12 months, while the secondary outcomes included medication adherence, the body mass index (BMI), and blood low-density lipoprotein. Results:The systolic BP between these two groups at four time points (F time =8.734, F group =172.075, and F interaction =11.363) was statistically significant (P<0.05). The self-health management ability at four time points during follow-up period (F time =115.09, F group =1,185.50, and F interaction =108.22) was also significantly different between these two groups. Furthermore, there was a statistically significant difference in compliance with medication at six months (χ 2 =37.616, P=0.000). However, after one year, there were no significant differences in BMI (t=0.214, P=0.644), total cholesterol (t=0.56, P=0.837), and low-density lipoprotein (t=0.042, P=0.455). Conclusions:The BHHM-led mHealth follow-up is an effective method for managing BP and improving the self-care ability. Furthermore, this approach has no obvious effect on the management of BMI and blood low-density lipoprotein. A potential signal of efficacy with the intervention was observed.

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Association of plaque enhancement on vessel wall MRI and the phosphodiesterase 4D variant with stroke recurrence in patients with symptomatic intracranial atherosclerosis

Qin

et al. 2022

Neuroradiology

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Ischemic Stroke and Genetic Variants: In Search of Association with Severity and Recurrence in a Brazilian Population

Cited by 5 publications

References 26 publications

Association between PDE4D rs966221 and the Risk of Ischemic Stroke in Regional Chinese Populations

Association between PDE4D rs966221 and the Risk of Ischemic Stroke in Regional Chinese Populations

A randomized controlled trial of brain and heart health manager-led mHealth secondary stroke prevention

Association of plaque enhancement on vessel wall MRI and the phosphodiesterase 4D variant with stroke recurrence in patients with symptomatic intracranial atherosclerosis

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