Ischemic stroke due to protein C deficiency

Abstract

Cardiovascular diseases are one of the common causes of high morbidity and mortality all over the world. Usually stroke occur in elderly, but stroke in younger group (age <45 years) are increasingly common now-a-days. The disease can occur in young patients without any apparent risk factors. It is therefore important to exclude all aetiological causes in order to reduce their chances for a subsequent event.Bangladesh Crit Care J September 2016; 4 (2): 123-124

Protein C Deficiency as a Risk Factor for Stroke in Young Adults: A Review

“…The treatment and management of PC deficiency are mostly based on previously reported cases and experiences. The mainstay of treatment in the majority of cases has been the use of anticoagulants such as heparin, warfarin, aspirin, and clopidogrel [2,[24][25][26][27][28][29][30][31][32]. There exist a paucity of data regarding the management of PC deficiency manifesting as stroke; hence, the aforementioned cases ( Table 4) have provided us some clue regarding the failure and success of various therapies.…”

“…Most physicians use long-term anticoagulation therapy for the prevention of thromboembolic events [44]. Based on the cases in Table 4, cerebral ischemia and infarction secondary to PC deficiency have been successfully managed by initial administration of heparin (mostly low molecular weight heparin) after hospital admission followed by long-term use of anticoagulant (warfarin in most of the cases) [26][27][28]31,36,[39][40][41][42].…”