Ischemic stroke shortly after vaccination against SARS-CoV-2: A case-control study

Vinciguerra, Luisa; Puglisi, Valentina; Giossi, Alessia; Valeria, De Giuli; Caprioli, Francesca; Costanzi, Chiara; Pari, Elisa; Maria, Tripodi Silvia; Clauida, Trapasso Maria; Censori, Bruno

doi:10.1016/j.jns.2022.120209

Cited by 6 publications

(8 citation statements)

References 8 publications

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“…Memory loss has not been reported after COVID-19 vaccination, although it is a possibility. For of its often-devastating clinical presentations, ischemic stroke following vaccination are common reported in literature ( Blauenfeldt et al, 2021 ; Luisa et al, 2022 ; Malik et al, 2021 ), whereas transient ischemic attack (TIA) after COVID-19 vaccination is probably undervalued, in our opinion. TIA can be associated with hypercoagulable state and attributed herein to the uptake of the vaccination, as also Malik et al (2021) reported.…”

Section: Discussionmentioning

confidence: 81%

Cognitive deficits and memory impairments after COVID-19 (Covishield) vaccination

Chaurasia

Chavda

et al. 2022

Brain, Behavior, & Immunity - Health

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Section: Discussionmentioning

confidence: 81%

Cognitive deficits and memory impairments after COVID-19 (Covishield) vaccination

Chaurasia

Chavda

et al. 2022

Brain, Behavior, & Immunity - Health

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“…Most descriptions of CVEs have been published as case reports (►Table 6). [103][104][105][106][107][108][109][110][111][112][113][114][115][116][117][118][119][120][121][122] Across 14 articles describing 17 cases, [109][110][111][112][113][114][115][116][117][118][119][120][121][122] 12/17 (76.9%) patients had significant CVE risk factors prior to presentation including hypertension, hyperlipidemia, diabetes mellitus, or previous stroke or myocardial infarction. Given the multifactorial nature of CVEs and the wide variety in presentations among selected reports, the specific relationship between COVID-19 vaccinations and CVEs remains weak.…”

Section: Cerebrovascular Eventsmentioning

confidence: 99%

“…New-onset seizures and epilepsy evidence tableCerebrovascular events (CVEs) such as stroke, intracerebral hemorrhage, or transient ischemic attack comprise a significant burden of disease worldwide, with an estimated 800,000 CVEs occurring each year in the United States and the incidence of events sharply rising with age 100,101. CVEs are associated with multiple well-studied risk factors including hypertension, diabetes mellitus, and tobacco use102 ; therefore, studies assessing the direct relationship between COVID-19 vaccines and CVEs are limited.Most descriptions of CVEs have been published as case reports (►Table 6) [103][104][105][106][107][108][109][110][111][112][113][114][115][116][117][118][119][120][121][122]. Across 14 articles describing 17 cases,[109][110][111][112][113][114][115][116][117][118][119][120][121][122] 12/17 (76.9%) patients had significant CVE risk factors prior to presentation including hypertension, hyperlipidemia, diabetes mellitus, or previous stroke or myocardial infarction.…”

mentioning

confidence: 99%

Neurological Considerations with COVID-19 Vaccinations

et al. 2023

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The benefits of coronavirus disease 2019 (COVID-19) vaccination significantly outweigh its risks on a public health scale, and vaccination has been crucial in controlling the spread of SARS-CoV-2. Nonetheless, several reports of adverse events following vaccination have been published.To summarize reports to date and assess the extent and quality of evidence regarding possible serious adverse neurological events following COVID-19 vaccination, focusing on Food and Drug Administration (FDA)-approved vaccines in the United States (BNT162b2, mRNA-1273, and Ad26.COV2.S).A review of literature from five major electronic databases (PubMed, Medline, Embase, Cochrane Library, and Google Scholar) was conducted between December 1, 2020 and June 5, 2022. Articles included in the review were systematic reviews and meta-analysis, cohort studies, retrospective studies, case–control studies, case series, and reports. Editorials, letters, and animal studies were excluded, since these studies did not include quantitative data regarding adverse side effects of vaccination in human subjects.Of 149 total articles and 97 (65%) were case reports or case series. Three phase 3 trials initially conducted for BNT162b2, MRNA-1273, and Ad26.COV2.S were included in the analysis.The amount and quality of evidence for possible neurological adverse events in the context of FDA-approved COVID-19 vaccinations is overall low tier. The current body of evidence continues to suggest that COVID-19 vaccinations have a high neurological safety profile; however, the risks and benefits of vaccination must continue to be closely monitored.

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“…Acute strokes affecting the posterior visual pathways have been reported extensively post–COVID-19 infection, occurring in a population that is younger with less risk factors, including in pediatric patients ( 34 ). There have been case reports describing ischemic strokes post–COVID-19 vaccination in the setting of vaccine-induced immune thrombotic thrombocytopenia ( 35 ); however, without the immune complication, the rate of ischemic strokes in vaccinated patients is similar to those who were not vaccinated ( 36 ).…”

Section: Visual Cortexmentioning

confidence: 99%