ISFET and Fiber Optic Sensor Technologies:  In Vivo Experience for Critical Care Monitoring

McKinley, Bruce A.

doi:10.1021/cr068120y

Cited by 30 publications

(26 citation statements)

References 144 publications

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“…[1][2][3][4][5][6] pH sensitive biosensors are extensively studied, since it has many applications, especially in the monitoring of biological systems such as blood, but also for chemical analysis and environment monitoring. [7][8][9][10][11] There are many options of materials that can be used as ion sensitive layers. However there is a continuous search for layers with higher sensitivities, specially using materials like biomolecules that could present sensitivities comparable to inorganic sensors.…”

Section: Introductionmentioning

confidence: 99%

Melanin as an active layer in biosensors

et al. 2014

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The development of pH sensors is of great interest due to its extensive application in several areas such as industrial processes, biochemistry and particularly medical diagnostics. In this study, the pH sensing properties of an extended gate field effect transistor (EGFET) based on melanin thin films as active layer are investigated and the physical mechanisms related to the device operation are discussed. Thin films were produced from different melanin precursors on indium tin oxide (ITO) and gold substrates and were investigated by Atomic Force Microscopy and Electrochemical Impedance Spectroscopy. Experiments were performed in the pH range from 2 to 12. EGFETs with melanin deposited on ITO and on gold substrates showed sensitivities ranging from 31.3 mV/pH to 48.9 mV/pH, depending on the melanin precursor and the substrate used. The pH detection is associated with specific binding sites in its structure, hydroxyl groups and quinone imine.

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Section: Introductionmentioning

confidence: 99%

Melanin as an active layer in biosensors

et al. 2014

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“…The main drawbacks of these achievements, otherwise challenging and fascinating, are the technological issues inherent to nanodevice fabrication and low-cost production. In addition, the electrochemically gated field-effect transistors (FET) need for a reference electrode affects, as yet, their full integration in complementary metal-oxide-semiconductor (CMOS) (9).…”

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confidence: 99%

Interfacial electronic effects in functional biolayers integrated into organic field-effect transistors

Angione

Cotrone

Magliulo

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

111

102

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Biosystems integration into an organic field-effect transistor (OFET) structure is achieved by spin coating phospholipid or protein layers between the gate dielectric and the organic semiconductor. An architecture directly interfacing supported biological layers to the OFET channel is proposed and, strikingly, both the electronic properties and the biointerlayer functionality are fully retained. The platform bench tests involved OFETs integrating phospholipids and bacteriorhodopsin exposed to 1-5% anesthetic doses that reveal drug-induced changes in the lipid membrane. This result challenges the current anesthetic action model relying on the so far provided evidence that doses much higher than clinically relevant ones (2.4%) do not alter lipid bilayers' structure significantly. Furthermore, a streptavidin embedding OFET shows label-free biotin electronic detection at 10 parts-per-trillion concentration level, reaching state-of-the-art fluorescent assay performances. These examples show how the proposed bioelectronic platform, besides resulting in extremely performing biosensors, can open insights into biologically relevant phenomena involving membrane weak interfacial modifications.organic electronics | analytical bioassay | electronic biodetection

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“…Another important issue is that newly developed systems or technologies must be significantly better and/or cheaper than existing ones. As an illustration, despite the fact that more than 400 patents were issued in the U.S. since 1976 on ISFET devices and technology, no US commercial products for medical applications resulted from these efforts [171].…”

Section: Applications Of Potentiometric Sensor Arraysmentioning

confidence: 99%