Islet Amyloid Polypeptide has No Effect on Amylase Release from Rat Pancreatic Acini Stimulated by CCK-8, Secretin, Carbachol and VIP.

Kikuchi, Yoshihiro; Koizumi, Masaru; Shimosegawa, Tooru; Kashimura, Jyunya; Suzuki, Susumu; Toyota, Takayoshi

doi:10.1620/tjem.165.41

Cited by 4 publications

(3 citation statements)

References 22 publications

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“…No effect of amylin on basal and stimulated amylase secretion from acinar cells has been reported (40,76). Funakoshi et al (50) observed a dose-independent stimulatory effect of amylin on pancreatic exocrine secretion in conscious rats, an effect attributed to inhibition of somatostatin secretion.…”

Section: Pancreatic Hormones and Neuropeptidesmentioning

confidence: 99%

The islet-acinar axis of the pancreas: more than just insulin

Barreto

Carati

Toouli³

et al. 2010

American Journal of Physiology-Gastrointestinal and Liver Physi

106

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Although the role of the islets in the regulation of acinar cell function seemed a mystery to investigators who observed their dispersion among pancreatic acini, over time an appreciation for this intricate and unique structural arrangement has developed. The last three decades have witnessed a steadily growing understanding of the interrelationship of the endocrine and the exocrine pancreas. The islet innervation and vascular anatomy have been more fully characterized and provide an appropriate background for our current understanding. The interrelationship between the endocrine and exocrine pancreas is mediated by islet-derived hormones such as insulin and somatostatin, other humoral factors including pancreastatin and ghrelin, and also neurotransmitters (nitric oxide, peptide YY, substance P, and galanin) released by the nerves innervating the pancreas. Although considerable progress has been achieved, further work is required to fully delineate the complex interplay of the numerous mechanisms involved. This review aims to provide a comprehensive update of the current literature available, bringing together data gleaned from studies addressing the actions of individual hormones, humoral factors, and neurotransmitters on the regulation of amylase secretion from the acinar cell. This comprehensive view of the islet-acinar axis of the pancreas while acknowledging the dominant role played by insulin and somatostatin on exocrine secretion sheds light on the influence of the various neuropeptides on amylase secretion.

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Section: Pancreatic Hormones and Neuropeptidesmentioning

confidence: 99%

The islet-acinar axis of the pancreas: more than just insulin

Barreto

Carati

Toouli³

et al. 2010

American Journal of Physiology-Gastrointestinal and Liver Physi

106

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“…This effect was seen at low concentrations of amylin (ED50 was 0.11 µg) comparable to effects reported on gastric emptying. However, multiple studies have shown no effect of amylin on secretion by isolated pancreatic acini or AR42J cells (75,142,337). Thus, there does not appear to be a direct effect of amylin on pancreatic exocrine cells and the in vivo effects may be on the CNS.…”

Section: E Amylinmentioning

confidence: 98%

Intermediate Filament Keratins in The Exocrine Pancreas

Alam¹,

Baghestani²,

Toivola³

Pancreapedia: Exocrine Pancreas Knowledge Base

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“…Amylin was also shown to stimulate protein secretion from pancreatic AR42J cells by a mechanism involving activation of GPCRs and release of Ca 2+ from intracellular stores (130). Others investigations have suggested that amylin has no effect on pancreatic exocrine secretion from isolated perfused pancreas, acinar preparations, or AR42J cells (72,153,351). Hence the effects of amylin on exocrine secretion remain unresolved.…”

Section: Amylinmentioning

confidence: 99%

Regulation of Pancreatic Secretion

Liddle

The Pancreapedia: Exocrine Pancreas Knowledge Base

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Islet Amyloid Polypeptide has No Effect on Amylase Release from Rat Pancreatic Acini Stimulated by CCK-8, Secretin, Carbachol and VIP.

Cited by 4 publications

References 22 publications

The islet-acinar axis of the pancreas: more than just insulin

The islet-acinar axis of the pancreas: more than just insulin

Intermediate Filament Keratins in The Exocrine Pancreas

Regulation of Pancreatic Secretion

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