Islets Transplanted Into the Eye: Do They Improve Our Insight Into Islet Adaptation to Insulin Resistance?

Improved in vivo imaging method for individual islets across the mouse pancreas reveals a heterogeneous insulin secretion response to glucose

“…Pancreatic slice cultures [12][13][14] and islets implanted in the anterior chamber of the eye [15][16][17][18][19] have more recently been developed to try and provide a more physiological and "in context" environment. Although these methods have proven immensely valuable, they are not without caveats and still differ significantly from the normal physiological environment 20 . Consequently, it is critical to understand the function of individual islets in vivo if we are to assess both the normal ability for glucose to provoke insulin secretion and the islet pathophysiology that is linked to the development of type 2 diabetes.…”