Isocoumarins. Developments Since 1950

Barry, Roger D.

doi:10.1021/cr60229a002

Cited by 239 publications

(108 citation statements)

References 113 publications

(196 reference statements)

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“…Bergenin is a C-glucoside and occurs in many plants, 18) such as Bergenia crassiflora (Saxifragaceae), Mallotus japonicus (Euphorbiaceae), and also Ardisia hortorum (Myrsinaceae). In bergenin biosynthesis, gallic acid (15) may be the glucosyl acceptor to be the precursor of bergenin from the result of the [ 14 C]-glucose incorporation experiment in Saxifraga stolonifera leaves.…”

Section: )mentioning

confidence: 99%

Ardisiphenols and Other Antioxidant Principles from the Fruits of Ardisia colorata.

et al. 2002

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Novel alkylphenols, ardisiphenols A-C (1-3) and a novel bergenin derivative, demethoxybergenin (10) were isolated from the fruits of Ardisia colorata (Myrsinaceae), together with known alkylresorcinols (4-6), embelin (7), myricetin (8), quercetin (9), bergenin (11), norbergenin (12), kaempferol (13), quercetin-3-O-b b-D-glucopyranoside (14) and gallic acid (15). Their structures were determined by NMR, MS(/MS) analyses and other spectroscopic methods. Ardisiphenols showed moderate scavenging activities toward 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals and showed cytotoxicity against the murine breast cancer cell line, FM3A.

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Section: )mentioning

confidence: 99%

Ardisiphenols and Other Antioxidant Principles from the Fruits of Ardisia colorata.

et al. 2002

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“…The alkyne 159 was prepared by modified Sonogashira procedure from o-iodobenzoic ester. These esters undergo quantitative cyclization in the presence of strong acids such as HBF 4 and TfOH to give salt 161 via 160, which are unstable. The slow hydrolysis of the tetrafluoroborate salts 161 at room temperature yielded the isocoumarin 162 (Scheme 34).…”

Section: Synthesis Via Isobenzopyrylium Saltsmentioning

confidence: 99%

“…For example, Barry, 4 Turner and Aldridge, 5 Napolitano, 6 Bin, 7 and Saeed 8 published reviews about isocoumarins and 3,4-dihydroisocoumarins.…”

Section: Introductionmentioning

confidence: 99%

Isocoumarins and 3,4-dihydroisocoumarins, amazing natural products: a review

Saddiqa¹,

Çakmak²,

Usman³

2017

Turk J Chem

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Abstract:The isocoumarins are naturally occurring lactones that constitute an important class of natural products exhibiting an array of biological activities. A wide variety of these lactones have been isolated from natural sources and, due to their remarkable bioactivities and structural diversity, great attention has been focused on their synthesis. This review article focuses on their structural diversity, biological applications, and commonly used synthetic modes.

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“…They are useful intermediates in the synthesis of a variety of carbocyclic and heterocyclic compounds [1][2][3][4][5][6] . In continuous of our interest in carbon-carbon bond formation reaction [7][8][9][10][11][12] , the present paper presents an efficient method to synthesize o-substituted benzophenones (2) from 3-substitued isocoumarins (1) and phenyl magnesium bromide in presence of anhydrous ether under dry ice-solvent bath.…”

Section: Introductionmentioning

confidence: 99%