2010
DOI: 10.1007/s00251-010-0488-2
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Isoforms of the nonclassical class I MHC antigen H2-Q5 are enriched in brain and encode Qdm peptide

Abstract: Although the human nonclassical class Ib major histocompatibility complex (Mhc) locus, HLA-G, is known to act as an immune suppressor in immune-privileged sites, little is currently known regarding participation of the rodent class Ib Mhc in similar pathways. Here, we investigated the expression properties of the mouse nonclassical Mhc H2-Q5(k) gene, previously detected in tumors and tissues associated with pregnancy. We find that H2-Q5(k) is alternatively spliced into multiple novel isoforms in a wide panel o… Show more

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Cited by 4 publications
(7 citation statements)
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“…In cod, we found one transcript originating from a beard library (GenBank accession GW844691.1, Additional file 4 : Text S1) and one match from a brain transcriptome library (Additional file 4 : Text S1, SRA dataset SRX148752) while transcriptomes from the immunologically important tissues spleen, hindgut and head kidney in addition to the organs heart, gonad and liver (SRA053026) were all negative. Also tetraodon displayed P lineage expression in the brain (SRA dataset SRX191169) suggesting P genes have a biological role in teleost brain potentially in line with the roles emerging for mammalian classical as well as non-classical MHCI molecules in brain development and function [ 79 - 81 ]. Expression of classical MHCI in developing fish brain was suggested by linkage analysis to be associated with behavior such as level of boldness [ 82 , 83 ], but no studies have yet focused on the function of non-classical MHCI in fish brains.…”
Section: Resultsmentioning
confidence: 99%
“…In cod, we found one transcript originating from a beard library (GenBank accession GW844691.1, Additional file 4 : Text S1) and one match from a brain transcriptome library (Additional file 4 : Text S1, SRA dataset SRX148752) while transcriptomes from the immunologically important tissues spleen, hindgut and head kidney in addition to the organs heart, gonad and liver (SRA053026) were all negative. Also tetraodon displayed P lineage expression in the brain (SRA dataset SRX191169) suggesting P genes have a biological role in teleost brain potentially in line with the roles emerging for mammalian classical as well as non-classical MHCI molecules in brain development and function [ 79 - 81 ]. Expression of classical MHCI in developing fish brain was suggested by linkage analysis to be associated with behavior such as level of boldness [ 82 , 83 ], but no studies have yet focused on the function of non-classical MHCI in fish brains.…”
Section: Resultsmentioning
confidence: 99%
“…In Atlantic cod, the single P lineage gene was not expressed in immunologically-important tissues such as spleen, hind gut, and head kidney underlining its nonclassical nature. However, both cod as well as tetraodon displayed P lineage expression in brain, suggesting that this gene may be involved in brain development and function similar to the emerging roles of mammalian nonclassical MHCI molecules in this organ [ 55 , 56 , 57 ].…”
Section: Teleost Mhcmentioning
confidence: 99%
“…Splice isoforms of Q5 appear to be enriched in brain (Renthal et al, 2011). Intriguingly, alternative splicing of MHCI genes was detected in hippocampus, but not at the NMJ.…”
Section: Discussionmentioning
confidence: 99%
“…The locations of primer binding determine the size of the predicted product, and also define the sequence area within which alternative splicing events will be detected. MHCI transcript skeleton adapted from (Renthal et al, 2011). …”
Section: Figurementioning
confidence: 99%