Isogeometric simulation of a derived stem cell engineered ventricle

Abstract

Regenerative cardiology recently advanced in patient-specific medicine by employing somatic cells to derive pluripotent stem cells and differentiate them into cardiomyocytes.In this work, the cardiac Monodomain model is coupled with stem cell ionic models to simulate the action potential propagation in the engineered ventricle. The cardiac model is then discretized by means of Isogeometric Analysis, carrying out numerical experiments to assess the accuracy of the approach. Finally, the presented framework is used to investigate the propagation of an action potential on the calibrated model of the engineered ventricle.