Isolated Compounds from Natural Products with Potential Antidiabetic Activity - A Systematic Review

Munhoz, Antônio Carlos Mattar; Fröde, Tânia Sílvia

doi:10.2174/1573399813666170505120621

Cited by 65 publications

(29 citation statements)

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“…In fact, the therapeutic potential of oleanolic acid was recently reviewed [108] and from that detailed work it is possible to conclude that indeed this natural compound is a good candidate to become a medicine. Due to this biological potential, the in vivo evaluations are increasing and in the last three years several publications involving the usual activities, such as antitumor [109,110,111], antidiabetic [112,113,114,115], anti-malarial [116] and anti-atherosclerosis [117] or the less common such as its beneficial effect on wound healing and regeneration [118] and the inhibition of matrix metalloproteinase-3 (MMP-3) production [119] have been published. It should be highlighted that this enzyme is involved in the articular cartilage destruction, thus oleanolic acid may be a potential drug to be used in the prevention of osteoarthritis cartilage damage [119].…”

Section: In Vivo Assessments Of Nominated Metabolitesmentioning

confidence: 99%

Scabiosa Genus: A Rich Source of Bioactive Metabolites

et al. 2018

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The genus Scabiosa (family Caprifoliaceae) is considered large (618 scientific plant names of species) although only 62 have accepted Latin binominal names. The majority of the Scabiosa species are widely distributed in the Mediterranean region and some Scabiosa species are used in traditional medicine systems. For instance, Scabiosa columbaria L. is used traditionally against diphtheria while S. comosa Fisch. Ex Roem. and Schult. is used in Mongolian and Tibetan traditional medical settings to treat liver diseases. The richness of Scabiosa species in secondary metabolites such as iridoids, flavonoids and pentacyclic triterpenoids may contribute to its use in folk medicine. Details on the most recent and relevant pharmacological in vivo studies on the bioactive secondary metabolites isolated from Scabiosa species will be summarized and thoroughly discussed.

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Section: In Vivo Assessments Of Nominated Metabolitesmentioning

confidence: 99%

Scabiosa Genus: A Rich Source of Bioactive Metabolites

et al. 2018

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“…Both oleanic acid (OA) and ursolic acid (UA) are two representative triterpenoids with certain solubility in water, methanol, ethanol, 2-propanol, and ethyl acetate [ 29 , 30 , 31 , 32 ]. These two compounds have been evidenced to exhibit a variety of activities, including stabilizing liposomal membranes [ 33 ], anti-cancer [ 34 ], anti-diabetes [ 35 , 36 ], anti-inflammation [ 37 ], anti-oxidation [ 2 ], anti-osteoporosis [ 38 , 39 ], etc. In addition, OA is the most abundant potent triterpenoid in FLL with a content ranging from 7.37 to 13.3 mg/g [ 40 ].…”

Section: Phytochemistry Of Fructus Ligustri Lucidimentioning

confidence: 99%

Fructus Ligustri Lucidi in Osteoporosis: A Review of its Pharmacology, Phytochemistry, Pharmacokinetics and Safety

et al. 2017

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Background: Fructus Ligustri Lucidi (FLL) has now attracted increasing attention as an alternative medicine in the prevention and treatment of osteoporosis. This study aimed to provide a general review of traditional interpretation of the actions of FLL in osteoporosis, main phytochemical constituents, pharmacokinetics, pharmacology in bone improving effect, and safety. Materials and Methods: Several databases, including PubMed, China National Knowledge Infrastructure, National Science and Technology Library, China Science and Technology Journal Database, and Web of Science were consulted to locate publications pertaining to FLL. The initial inquiry was conducted for the presence of the following keywords combinations in the abstracts: Fructus Ligustri Lucidi, osteoporosis, phytochemistry, pharmacokinetics, pharmacology, osteoblasts, osteoclasts, salidroside. About 150 research papers and reviews were consulted. Results: FLL is assumed to exhibit anti-osteoporotic effects by improving liver and kidney deficiencies and reducing lower back soreness in Traditional Chinese Medicine (TCM). The data from animal and cell experiments demonstrate that FLL is able to improve bone metabolism and bone quality in ovariectomized, growing, aged and diabetic rats through the regulation of PTH/FGF-23/1,25-(OH)2D3/CaSR, Nox4/ROS/NF-κB, and OPG/RANKL/cathepsin K signaling pathways. More than 100 individual compounds have been isolated from this plant. Oleanolic acid, ursolic acid, salidroside, and nuzhenide have been reported to exhibit the anti-osteoporosis effect. The pharmacokinetics data reveals that salidroside is one of the active constituents, and that tyrosol is hard to detect under physiological conditions. Acute and subacute toxicity studies show that FLL is well tolerated and presents no safety concerns. Conclusions: FLL provides a new option for the prevention and treatment of osteoporosis, which attracts rising interests in identifying potential anti-osteoporotic compounds and fractions from this plant. Further scientific evidences are expected from well-designed clinical trials on its bone protective effects and safety.

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“…Interestingly, flavonoids such as rutin have been shown previously to exert antihyperglycaemic effects in STZ-induced diabetic rats [ 50 ]. This was associated with inhibition of α-glucosidase activity [ 51 ] and increased insulin secretion from rat pancreatic islets [ 52 ]. Rutin is widely distributed in edible plants [ 53 ] can be biotransformed into quercetin and isoquercitrin [ 54 , 55 ] which may have better antidiabetic properties.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Antidiabetic and Insulin Releasing Effects of A. squamosa, Including Isolation and Characterization of Active Phytochemicals

Ansari

Flatt

Harriott

et al. 2020

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Annona squamosa is generally referred to as a ‘custard apple’. Antidiabetic actions of hot water extract of Annona squamosa (HWAS) leaves together with isolation of active insulinotropic compounds were studied. Insulin release, membrane potential and intracellular Ca2+ were determined using BRIN-BD11 cells and isolated mouse islets. 3T3L1 adipocytes and in vitro models were used to determine cellular glucose uptake, insulin action, starch digestion, glucose diffusion, DPP-IV activity and glycation. Glucose intolerant high-fat fed rats were used for in vivo studies. Active compounds were isolated and characterized by HPLC, LCMS and NMR. HWAS stimulated insulin release from clonal β-cells and mouse islets. Using fluorescent indicator dyes and modulators of insulin secretion, effects could be attributed to depolarization of β-cells and influx of Ca2+. Secretion was stimulated by isobutylmethylxanthine (IBMX), tolbutamide or 30 mM KCl, indicating additional non-KATP dependent pathways. Extract stimulated cellular glucose uptake and insulin action and inhibited starch digestion, protein glycation, DPP-IV enzyme activity and glucose diffusion. Oral HWAS improved glucose tolerance and plasma insulin in high-fat fed obese rats. Treatment for 9 days with HWAS (250 mg/5 mL/kg), partially normalised energy intake, body weight, pancreatic insulin content, and both islet size and beta cell mass. This was associated with improved oral glucose tolerance, increased plasma insulin and inhibition of plasma DPP-IV activity. Isolated insulinotropic compounds, including rutin (C27H30O16), recapitulated the positive actions of HWAS on beta cells and in vivo glucose tolerance and plasma insulin responses. Annona squamosa is attractive as a dietary adjunct in treatment of T2DM and as a source of potential antidiabetic agents including rutin.

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Isolated Compounds from Natural Products with Potential Antidiabetic Activity - A Systematic Review

Abstract: This review contributes to the field of ethnopharmacology and should impact the design of new strategies in the search of novel compounds for the treatment of diabetic conditions.

Cited by 65 publications

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Scabiosa Genus: A Rich Source of Bioactive Metabolites

Scabiosa Genus: A Rich Source of Bioactive Metabolites

Fructus Ligustri Lucidi in Osteoporosis: A Review of its Pharmacology, Phytochemistry, Pharmacokinetics and Safety

Evaluation of the Antidiabetic and Insulin Releasing Effects of A. squamosa, Including Isolation and Characterization of Active Phytochemicals

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