Isolated Hepatic Metastasis from Prostate Carcinoma

Wang, Stephani C.; McCarthy, Lezah; Mehdi, Syed

doi:10.1016/j.eucr.2016.11.012

Cited by 14 publications

(13 citation statements)

References 4 publications

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“…Liver metastases typically occur in systemic, late stage, hormone refractory disease [10]. However, there are reports of patients with liver metastases as the first site of metastatic disease and the liver representing the only metastatic site [10, 12, 13]. Especially in this patient collective, early and reliable detection of liver metastases is of high clinical importance for accurate staging and therapy planning.…”

Section: Introductionmentioning

confidence: 99%

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68Ga-PSMA-PET/CT for the evaluation of liver metastases in patients with prostate cancer

et al. 2019

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Background The purpose of this study was to evaluate the imaging properties of hepatic metastases in 68 Ga-PSMA positron emission tomography (PET) in patients with prostate cancer (PC). Methods 68 Ga-PSMA-PET/CT scans of PC patients available in our database were evaluated retrospectively for liver metastases. Metastases were identified using 68 Ga-PSMA-PET, CT, MRI and follow-up scans. Different parameters including, maximum standardized uptake values (SUV max ) of the healthy liver and liver metastases were assessed by two- and three-dimensional regions of interest (2D/3D ROI). Results One hundred three liver metastases in 18 of 739 PC patients were identified. In total, 80 PSMA-positive (77.7%) and 23 PSMA-negative (22.3%) metastases were identified. The mean SUV max of PSMA-positive liver metastases was significantly higher than that of the normal liver tissue in both 2D and 3D ROI ( p ≤ 0.05). The mean SUV max of PSMA-positive metastases was 9.84 ± 4.94 in 2D ROI and 10.27 ± 5.28 in 3D ROI; the mean SUV max of PSMA-negative metastases was 3.25 ± 1.81 in 2D ROI and 3.40 ± 1.78 in 3D ROI, and significantly lower than that of the normal liver tissue ( p ≤ 0.05). A significant (p ≤ 0.05) correlation between SUV max in PSMA-positive liver metastases and both size (ρ Spearman = 0.57) of metastases and PSA serum level (ρ Spearman = 0.60) was found. Conclusions In 68 Ga-PSMA-PET, the majority of liver metastases highly overexpress PSMA and is therefore directly detectable. For the analysis of PET images, it has to be taken into account that also a significant portion of metastases can only be detected indirectly, as these metastases are PSMA-negative.

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Section: Introductionmentioning

confidence: 99%

“…Furthermore, the relatively high background activity of the liver might also affect the visibility of liver metastases in 68 Ga-PSMA-PET [14]. Imaging of hepatic PC metastases in 68 Ga-PSMA-PET has been reported in case reports, but not been systematically researched in a larger cohort of patients [12, 15–18].…”

Section: Introductionmentioning

confidence: 99%

68Ga-PSMA-PET/CT for the evaluation of liver metastases in patients with prostate cancer

et al. 2019

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“…To date, no established locoregional treatment regimens specifically addressing hepatic involvement in prostatic cancer exist. Wang et al [ 17 ] reported 1 case with isolated liver spread and successful surgical resection of a solitary liver metastasis. Due to the multitude of liver metastases in both lobes, liver surgery was no treatment option in our patient.…”

Section: Discussionmentioning

confidence: 99%

Successful Yttrium-90 Microsphere Radioembolization for Hepatic Metastases of Prostate Cancer

et al. 2017

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Prostate cancer is the most common solid tumor malignancy worldwide with an estimated 180,000 new cases of prostate cancer and 26,000 deaths in the USA in 2016. Although significant advances in the treatment of prostate cancer have recently been made, the treatment of metastatic disease remains a challenge. With visceral metastases marking more advanced tumor stages, liver involvement is associated with the worst prognosis. So far, no locoregional treatment regimens for the management of liver metastases of prostatic cancer exist. Herein, we report for the first time a successful treatment of hepatic metastases of prostatic cancer using radioembolization with selective intra-arterial administration of Yttrium-90 resin microspheres.

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“…Liver metastases have high incidence in some cancers (breast [146], colorectal [147], and prostate [148]), and it is also of interest in medical research. Breast cancer liver metastasis animal models are developed through portal vein inoculations [149].…”

Section: Intravenous Inoculationmentioning

confidence: 99%

Spontaneous and Induced Animal Models for Cancer Research

Onaciu

Munteanu

et al. 2020

Diagnostics

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Considering the complexity of the current framework in oncology, the relevance of animal models in biomedical research is critical in light of the capacity to produce valuable data with clinical translation. The laboratory mouse is the most common animal model used in cancer research due to its high adaptation to different environments, genetic variability, and physiological similarities with humans. Beginning with spontaneous mutations arising in mice colonies that allow for pursuing studies of specific pathological conditions, this area of in vivo research has significantly evolved, now capable of generating humanized mice models encompassing the human immune system in biological correlation with human tumor xenografts. Moreover, the era of genetic engineering, especially of the hijacking CRISPR/Cas9 technique, offers powerful tools in designing and developing various mouse strains. Within this article, we will cover the principal mouse models used in oncology research, beginning with behavioral science of animals vs. humans, and continuing on with genetically engineered mice, microsurgical-induced cancer models, and avatar mouse models for personalized cancer therapy. Moreover, the area of spontaneous large animal models for cancer research will be briefly presented.

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Isolated Hepatic Metastasis from Prostate Carcinoma

Cited by 14 publications

References 4 publications

68Ga-PSMA-PET/CT for the evaluation of liver metastases in patients with prostate cancer

68Ga-PSMA-PET/CT for the evaluation of liver metastases in patients with prostate cancer

Successful Yttrium-90 Microsphere Radioembolization for Hepatic Metastases of Prostate Cancer

Spontaneous and Induced Animal Models for Cancer Research

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