Isolated mitral regurgitation complicating relapsing polychondritis

Patient Perception of Disease‐Related Symptoms and Complications in Relapsing Polychondritis

“…RP is defined by inflammation of cartilaginous structures and the disease course and clinical manifestations are highly variable. End organ complications due to inflammation of cartilage and proteoglycan rich structures are diverse and include deformity of the ears(2), nose(3) and chest(4), subglottic stenosis (5), obstructive lung disease, tracheomalacia(6), bronchomalacia(7), recurrent pneumonia(8), mitral and aortic regurgitation(9, 10), large and medium vessel aneurysms(11), blindness(12), deafness(13), renal insufficiency(14), chronic pain, and sudden death(15–17). The protean aspects of RP pose diagnostic challenges.…”

Optic Neuropathy Associated With Periostitis in Relapsing Polychondritis

“…We believe our diagnosis of RPC is justified on the basis of the modified McAdam criteria, which specify the presence of chondritis at two or more separate anatomic locations with response to corticosteroids or dapsone (52)(53)(54). She also had mitral valve regurgitation, which has been reported in RPC (55,56). Finally, there was no serologic support for WG or alternative diseases.…”

Rupture of chordae tendineae in patients with β‐thalassemia

“…Rupture of chordae tendineae may be idiopathic or may develop in association with a number of conditions including mitral valve prolapse syndrome, infective endocarditis, trauma, acute rheumatic fever and connective tissue disorders (3, 4). Mitral regurgitation following chordal rupture may be acute, subacute or chronic, with a severity varying from mild to severe (5).…”

“…Mitral regurgitation following chordal rupture may be acute, subacute or chronic, with a severity varying from mild to severe (5). Connective tissue disorders that have been associated with chordal rupture include Ehlers‐Danlos and Marfan syndromes, osteogenesis imperfecta and relapsing polychondritis (3, 4).…”