Isolated optic nerve involvement in chronic myeloid leukemia

Ophthalmologic manifestations as the initial presentation of chronic myeloid leukemia: A review

“…The median age was 37.05 years (range 27.5-49), and 67.5 % of patients were male. Most of the cases were initial presentations of CML (33 cases), and only five of them were in relapses 4,[8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][25][26][27][28][29][30][31][32][35][36][37][39][40][41][42][43][44][45][46][47] . The retina was most often involved, with retinal hemorrhages as the most common finding.…”

“…Nine presented with unilateral CML-related ophthalmic findings. 12,17,20,22,27,32,33,39,42 Eight of these had unilaterallydecreased of vision, and 1 had normal vision. 12 Thirty-one patients presented with bilateral ophthalmic findings 4,[8][9][10][11][13][14][15][16]18,19,[23][24][25][26][28][29][30][31][32][34][35][36][37][38][40][41][42]44,46 .…”

“…12,17,20,22,27,32,33,39,42 Eight of these had unilaterallydecreased of vision, and 1 had normal vision. 12 Thirty-one patients presented with bilateral ophthalmic findings 4,[8][9][10][11][13][14][15][16]18,19,[23][24][25][26][28][29][30][31][32][34][35][36][37][38][40][41][42]44,46 . Four of these patients had normal vision upon presentation 9,13,24,34 , while 11 patients had unilateral decrease of vision 10,14,16,17,25,26,32,…”

“…Rarely, leukemic cells invade the vitreous cavity and cause vitritis. 11 If the choroid (the most vascularized tissue of the eye) is involved, this may lead to choroidal infiltrates 17,19 and exudative retinal detachment 11,12,50 .…”

Ophthalmologic Manifestations as Initial Presentation of Patients with Chronic Myeloid Leukemia: Report of Two Cases

“…Adjunct radiation may be applied to lesions of the optic nerve or orbit. Of note, the various chemotherapeutic agents used to treat leukemia may cause ocular toxicity such as cataract development, cranial nerve palsies, optic atrophy, and intraocular inflammation [3][4][5][6][7][8][9][10][11][12][13].…”