Isolated tumor cells in the regional lymph nodes in patients with squamous cell carcinoma of the esophagus are rarely observed but often represent part of a true metastasis

Jepsen, Dea Natalie Munch; Fiehn, Anne-Marie Kanstrup; Svendsen, Bonnie; Achiam, Michael Patrick; Federspiel, Birgitte

doi:10.1016/j.anndiagpath.2020.151478

Cited by 2 publications

(2 citation statements)

References 25 publications

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“…Because the lymphatic network between the esophagus and the mediastinum connects each other, lymph node metastasis can be not only continuous, but also bidirectional and skipped. 14,15 However, Liu Liang et al 16 have confirmed that total 2FLND can reduce the rate of lymph node metastasis. We believe that although total 2FLND increased the scope and number of dissected lymph nodes, the results of this study were affected in that lymph node metastasis of EC always occurs early, and most patients in this study were locally advanced.…”

Section: A H E a D O F P R I N Tmentioning

confidence: 99%

Effects of standard and total two-field lymph node dissection on prognosis of patients undergoing Esophagectomy

Guo¹,

Li²,

Wang³

et al. 2022

Pak J Med Sci

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Objectives: To investigate the effects of standard two-field lymph node dissection (2FLND) and total 2FLND on the short-term and long-term clinical efficacy and complications of patients undergoing esophagectomy. Methods: The clinical data of 268 patients undergoing radical Ivor-Lewis esophagectomy in our hospital from January 2008 to November 2015 were analyzed retrospectively. According to different methods of lymph node dissection (LND), the patients were divided into standard 2FLND group (n = 121) and total 2FLND group (n = 147). The LND status, postoperative complications, survival rate and lymph node recurrence of the two groups were analyzed. Results: Lymph node metastasis rate showed no statistically significant difference between the standard 2FLND group and the total 2FLND group (71.1% and 63.3%, respectively, P > 0.05). The incidence of postoperative complications was 5.8% (7/121) in the standard 2FLND group, which was lower than that in the total 2FLND group [17.0% (25/147)], with a statistically significant difference (χ2 = 7.948, P < 0.01). The 5-year survival rate of the standard 2FLND group and the total 2FLND group was 29.8% and 28.6%, respectively, without statistically significant difference (χ2 = 0.005, P > 0.05). The lymph node recurrence rate in the standard 2FLND group was 41.3% (50/121), which was higher than 19.0% (28/147) of the total 2FLND group (χ2 = 15.959, P < 0.01). Conclusion: Compared with standard 2FLND, total 2FLND does not improve the postoperative survival of patients with esophageal carcinoma, and the risk of complications is higher. doi: https://doi.org/10.12669/pjms.38.4.4031 How to cite this:Guo Q, Li H, Wang H, Zhang D, Li Y. Effects of standard and total two-field lymph node dissection on prognosis of patients undergoing Esophagectomy. Pak J Med Sci. 2022;38(4):---------. doi: https://doi.org/10.12669/pjms.38.4.4031 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: A H E a D O F P R I N Tmentioning

confidence: 99%

Effects of standard and total two-field lymph node dissection on prognosis of patients undergoing Esophagectomy

Guo¹,

Li²,

Wang³

et al. 2022

Pak J Med Sci

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“…Esophageal cancer is one of the gastrointestinal malignancies with high morbidity and mortality because of its insidious symptoms, high malignancy, and powerful evasiveness [1][2][3]. Esophageal squamous cell carcinoma (ESCC) is the most common histological type [4], which is characterized by advanced diagnosis, metastasis, drug resistance, and frequent recurrence, and more than 50% of patients have unresectable tumors or metastatic lesions at the time of diagnosis [5]. Although the progresses of diagnosis and treatment technology have greatly improved the prognosis of ESCC patients in recent decades, the 5-year survival rate remains low at approximately 15-20% [4,6].…”

Section: Introductionmentioning

confidence: 99%

Aspirin Exerts Its Antitumor Effect in Esophageal Squamous Cell Carcinoma by Downregulating the Expression of ATAD2 and KIF4A

Zhang

Ren

Wang

et al. 2022

Analytical Cellular Pathology

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Objective. To investigate the expression of ATPase family AAA domain-containing protein 2 (ATAD2) and kinesin family member 4A (KIF4A) in esophageal squamous cell carcinoma (ESCC) tissues and their association with clinicopathological features and to explore the role of ATAD2 in regulating KIF4A expression and biological functions in ESCC cells and the effect of aspirin on their expression. Methods. The mRNA and protein expression of ATAD2 and KIF4A in the tissues of patients with ESCC were measured by RT-qPCR and immunohistochemistry, and the correlation between the expression of mRNA and clinicopathological characteristics was analyzed. Western blot and RT-qPCR were used to detect the interference efficiency and KIF4A expression after si-ATAD2 transfection in EC109 and KYSE30 cells. CCK-8 and Transwell assay were performed to investigate the effects of ATAD2 and aspirin on proliferation, migration, and invasion of ESCC cells. The effect of aspirin on the expression of ATAD2 and KIF4A in ESCC cells was measured by RT-qPCR and Western blot. Results. The expression of ATAD2 and KIF4A was upregulated in ESCC tissues, and both were correlated with the differentiation grades and lymph node metastasis. Knockdown of ATAD2 in ESCC cells significantly inhibited cell proliferation, migration, and invasion. Compared to the negative control group, the proliferation, migration, and invasion ability of ESCC cells in the aspirin-treated groups were decreased, and the expression of ATAD2 and KIF4A in ESCC cells was decreased after treating with aspirin for 48 h. Conclusion. The expression levels of ATAD2 and KIF4A are elevated in ESCC. ATAD2 promotes proliferation, migration, and invasion of ESCC cells by regulating KIF4A. Aspirin can inhibit the malignant behavior of ESCC cells by downregulating ATAD2 and KIF4A.

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Isolated tumor cells in the regional lymph nodes in patients with squamous cell carcinoma of the esophagus are rarely observed but often represent part of a true metastasis

Cited by 2 publications

References 25 publications

Effects of standard and total two-field lymph node dissection on prognosis of patients undergoing Esophagectomy

Effects of standard and total two-field lymph node dissection on prognosis of patients undergoing Esophagectomy

Aspirin Exerts Its Antitumor Effect in Esophageal Squamous Cell Carcinoma by Downregulating the Expression of ATAD2 and KIF4A

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