Isolation and antitumor efficacy evaluation of a polysaccharide from Nostoc commune Vauch.

Abstract

Nostoc commune Vauch. has been traditionally used as a healthy food and medicine for centuries especially in China. It has been demonstrated that the polysaccharides isolated from Nostoc commune Vauch. exhibit strong antimicrobial and antioxidant activities. However, little is known about their anticancer activities and the underlying mechanisms of action. Herein, we report the isolation of a polysaccharide from Nostoc commune Vauch. (NVPS), and its physicochemical properties were analyzed. In an attempt to demonstrate the potential application of NVPS in tumor chemotherapy, the in vitro antitumor activity was determined. NVPS significantly suppressed the growth and proliferation of MCF-7 and DLD1 cells. The molecular mechanism underlying this in vitro antitumor efficacy was elucidated, and the results indicated that NVPS simultaneously triggered intrinsic, extrinsic and endoplasmic reticulum stress (ERS)-mediated apoptotic signaling pathways. Collectively, these findings demonstrate that NVPS could be used as a novel promising source of natural antitumor agents.

Physicochemical Characterization and Functional Analysis of the Polysaccharide from the Edible Microalga Nostoc sphaeroides

“…In addition to induction of apoptosis, other mechanisms may also be involved in the anti-proliferative effect of Nostoc polysaccharides. For example, a polysaccharide from N. commune is able to suppress proliferation of MCF-7 cells via modulation of endoplasmic reticulum stress, which is known to trigger unfolded protein response and lead to cell death [ 53 ]. Also, a number of studies have shown that the anti-tumor activity of polysaccharides is closely associated with their regulatory effects on immune system [ 54 , 55 ], and, intriguingly, N. commune polysaccharide has been previously shown to activate the complement system [ 2 ], an important part of the immune system acting to enhance the adaptive immune response.…”

Biofertilization With Chlorophyta and Cyanophyta: An Alternative for Organic Food Production

“…Some chlorophytes and most cyanophytes have a high production of these polysaccharides and mucilage, as they are components of the cell wall (Ghosh, 2018). Recent research uncovered their many possible applications not only in agriculture but also in biomedicine due to their antibacterial, antiviral, antifungal, and anticoagulant activity (Guo et al, 2015;Berri et al, 2016;Faggio et al, 2016).…”

Biological activity of methanol extract from Nostoc sp. N42 and Fischerella sp. S29 isolated from aquatic and terrestrial ecosystems

“…Полисахарид из Nostoc commune Vauch. может запускать внешние, внутренние и эндоплазматические ретикулумные стрессы (ERS)опосредованных апоптотических сигнальных путей и может использоваться в качестве нового перспективного источника природных противоопухолевых агентов (Guo, 2015). Апоптоз является важным процессом для предотвращения рака, и раковые клетки избегают этих процессов, поэтому в настоящее время многие усилия направлены на то, чтобы заставить раковые клетки перейти в апоптотическую стадию.…”