Isolation and characterization of a novel xanthone from the hairy root cultures of Swertia chirayita (Roxb.) H. Karst. and its biological activity

Mahendran, G.; Verma, Narsingh; Singh, Shilpi; Parveen, Shabana; Singh, Manju; Luqman, Suaib; Shanker, Karuna; Rahman, Laiq ur

doi:10.1016/j.indcrop.2021.114369

Cited by 14 publications

(2 citation statements)

References 96 publications

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“…The medicinal benefits of S. chirayita leaves have antiviral, analgesic, hypoglycemic, and antimalarial characteristics. S. chiravita also possesses anti-cancer, antimicrobial, and anti-allergic activities [ 7 ]. It also reduces blood sugar levels through its impact on insulin release [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Biochemical characterization of bioinspired nanosuspensions from Swertia chirayita extract and their therapeutic effects through nanotechnology approach

Raza,

Ali,

Naeem

et al. 2024

PLoS ONE

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Swertia chirayita is used as a traditional medicinal plant due to its pharmacological activities, including antioxidant, antidiabetic, antimicrobial, and cytotoxic. This study was aimed to evaluate the therapeutic efficacy of newly synthesized nanosuspensions from Swertia chirayita through nanotechnology for enhanced bioactivities. Biochemical characterization was carried out through spectroscopic analyses of HPLC and FTIR. Results revealed that extract contained higher TPCs (569.6 ± 7.8 mg GAE/100 g)) and TFCs (368.5 ± 9.39 mg CE/100 g) than S. chirayita nanosuspension, TPCs (500.6 ± 7.8 500.6 ± 7.8 mg GAE/100 g) and TFCs (229.5± 3.85 mg CE/100 g). Antioxidant activity was evaluated through DPPH scavenging assay, and nanosuspension exhibited a lower DPPH free radical scavenging potential (06 ±3.61) than extract (28.9± 3.85). Anti-dabetic potential was assessed throughα-amylase inhibition and anti-glycation assays. Extract showed higher (41.4%) antiglycation potential than 35.85% nanosuspension and 19.5% α-amylase inhibitory potential than 5% nanosuspension. Biofilm inhibition activity against E. coli was higher in nanosuspension (69.12%) than extract (62.08%). The extract showed high cytotoxicity potential (51.86%) than nanosuspension (33.63%). These nanosuspensions possessed enhanced bioactivities for therapeutic applications could be explored further for the development of new drugs.

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Section: Introductionmentioning

confidence: 99%

Biochemical characterization of bioinspired nanosuspensions from Swertia chirayita extract and their therapeutic effects through nanotechnology approach

Raza,

Ali,

Naeem

et al. 2024

PLoS ONE

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“…According to the Chinese Pharmacopoeia, the dried whole herb of S. pseudochinensis is used as a traditional Chinese medicine called Swertiae Herba, with antipyretic-alexipharmic and stomachic effects. [1] Through previous studies on Swertia genus, it can be known that the chemical constituents of Swertia genus include flavonoids, [2] iridoids, [3] xanthones, triterpenoids and alkaloids, [4] and they have been shown to have hepatoprotective, [5] anti-tumor, [6] anti-inflammatory, [7,8] antioxidant, and hypoglycemic activities [9,10] in further pharmacological studies.…”

Section: Introductionmentioning

confidence: 99%

Xanthones and Phenylpropanoids from the Whole Herb of Swertia pseudochinensis and Their Anti‐Inflammatory Activity

Yan

et al. 2023

Chemistry & Biodiversity

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An undescribed xanthone dimer, 1,3,5,8-tetrahydroxy-7-(1',5',8'-trihydroxy-3'-methoxy-2'-xanthonyl)xanthone (1) was separated together with eleven known compounds (2 -12) from the dried whole herb of Swertia pseudochinensis. It was the first time that the compounds 8-12 were isolated from the Swertia genus. The structure of compound 1 was illuminated based on chemical evidence and spectral data analysis (UV, 1D and 2D-NMR, HR-ESI-MS). Moreover, the inhibitory effects of all compounds on NO production in LPS-induced RAW 264.7 cells were tested, compounds 8, 9, 10, 11 and 12 showing significant inhibition. The IC 50 value of compound 12 was 3.05 � 1.10 μM. Using target screening and molecular docking, we hypothesized that compound 12 may bind neutrophil elastase to exert its anti-inflammatory effects.

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Induction and metabolomic analysis of hairy roots of Atractylodes lancea

Zhang,

Guo,

Wang

et al. 2023

Appl Microbiol Biotechnol

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Isolation and characterization of a novel xanthone from the hairy root cultures of Swertia chirayita (Roxb.) H. Karst. and its biological activity

Cited by 14 publications

References 96 publications

Biochemical characterization of bioinspired nanosuspensions from Swertia chirayita extract and their therapeutic effects through nanotechnology approach

Biochemical characterization of bioinspired nanosuspensions from Swertia chirayita extract and their therapeutic effects through nanotechnology approach

Xanthones and Phenylpropanoids from the Whole Herb of Swertia pseudochinensis and Their Anti‐Inflammatory Activity

Induction and metabolomic analysis of hairy roots of Atractylodes lancea

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