Isolation and characterization of arsenic-binding siderophores from Rhodococcus erythropolis S43: role of heterobactin B and other heterobactin variants

Retamal-Morales, Gerardo; Senges, Christoph Helmut Rudi; Stapf, Manuel; Olguín, Angel; Modak, Brenda; Bandow, Julia E.; Tischler, Dirk; Schlömann, Michael; Levicán, Gloria

doi:10.1007/s00253-021-11123-2

Cited by 13 publications

(5 citation statements)

References 34 publications

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“…These acids have low reactivity, which makes the surface of mycobacteria waxy and extremely hydrophobic [ 74 ]. According to multiple studies, mycolic acids ensure the resistance of R. erythropolis to various stress factors and pollutants, such as oil products and heavy metals [ 75 , 76 , 77 , 78 , 79 ], and also allow survival on very poor nutrient media [ 80 ]. We assume that the presence of a negative effect of NCs on the viability of Cms is associated with the absence of mycolic acids in the cell wall of this bacterium.…”

Section: Discussionmentioning

confidence: 99%

Novel Nanobiocomposites Based on Natural Polysaccharides as Universal Trophic Low-Dose Micronutrients

Khutsishvili

Perfileva

Ножкина

et al. 2021

IJMS

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New promising manganese-containing nanobiocomposites (NCs) based on natural polysaccharides, arabinogalactan (AG), arabinogalactan sulfate (AGS), and κ-carrageenan (κ-CG) were studied to develop novel multi-purpose trophic low-dose organomineral fertilizers. The general toxicological effects of manganese (Mn) on the vegetation of potatoes (Solanum tuberosum L.) was evaluated in this study. The essential physicochemical properties of this trace element in plant tissues, such as its elemental analysis and its spectroscopic parameters in electron paramagnetic resonance (EPR), were determined. Potato plants grown in an NC-containing medium demonstrated better biometric parameters than in the control medium, and no Mn accumulated in plant tissues. In addition, the synthesized NCs demonstrated a pronounced antibacterial effect against the phytopathogenic bacterium Clavibacter sepedonicus (Cms) and were proved to be safe for natural soil microflora.

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Section: Discussionmentioning

confidence: 99%

Novel Nanobiocomposites Based on Natural Polysaccharides as Universal Trophic Low-Dose Micronutrients

Khutsishvili

Perfileva

Ножкина

et al. 2021

IJMS

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“…Siderophore production has been demonstrated by Streptomyces strains that produce hydroxamate-type siderophores known as deferoxamine [ 20 ]. Moreover, heterobactins are catecholate-hydroximate mixed-type siderophores that have been found in Rhodococcus erythropolis [ 46 ], and albisporachelin is a hydroxamate-type siderophore produced by Amycolatopsis albispora [ 47 ]. A sufficient amount of siderophore production by biocontrol agents limits Fe 3+ availability for phytopathogenic fungi.…”

Section: Main Actinomycete Antagonistic Mechanisms To Phytopathogenic...mentioning

confidence: 99%

Actinomycete Potential as Biocontrol Agent of Phytopathogenic Fungi: Mechanisms, Source, and Applications

Torres-Rodríguez¹,

Pérez

Quiñones-Aguilar³

et al. 2022

Plants

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Synthetic fungicides have been the main control of phytopathogenic fungi. However, they cause harm to humans, animals, and the environment, as well as generating resistance in phytopathogenic fungi. In the last few decades, the use of microorganisms as biocontrol agents of phytopathogenic fungi has been an alternative to synthetic fungicide application. Actinomycetes isolated from terrestrial, marine, wetland, saline, and endophyte environments have been used for phytopathogenic fungus biocontrol. At present, there is a need for searching new secondary compounds and metabolites of different isolation sources of actinomycetes; however, little information is available on those isolated from other environments as biocontrol agents in agriculture. Therefore, the objective of this review is to compare the antifungal activity and the main mechanisms of action in actinomycetes isolated from different environments and to describe recent achievements of their application in agriculture. Although actinomycetes have potential as biocontrol agents of phytopathogenic fungi, few studies of actinomycetes are available of those from marine, saline, and wetland environments, which have equal or greater potential as biocontrol agents than isolates of actinomycetes from terrestrial environments.

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“…Pyocyanin is a vital virulence factor for infection and biofilm formation in P. aeruginosa PAO1 ( Retamal-Morales et al., 2021 ). It can be seen that HMMN can inhibit pyocyanin production at different concentrations ( Figure 5C ).…”

Section: Resultsmentioning

confidence: 99%

2-Hydroxymethyl-1-methyl-5-nitroimidazole, one siderophore inhibitor, occludes quorum sensing in Pseudomonas aeruginosa

Yin

Wang

Liu

et al. 2022

Front. Cell. Infect. Microbiol.

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Siderophore is necessary for the survival of microorganisms and is interregulated with quorum sensing (QS) systems. It is related to growth, proliferation, virulence, and other bacterial social activities as a virulence factor. Thus, we speculated that the QS system could be occluded by inhibiting siderophore production. 2-Hydroxymethyl-1-methyl-5-nitroimidazole (HMMN), one siderophore inhibitor of Pseudomonas aeruginosa PAO1 (P. aeruginosa PAO1), was obtained by using the Chromeazurol S (CAS) method. We found that HMMN inhibited siderophore production and influenced the biological effects of QS regulation, including biofilm formation and pyocyanin production. HMMN (150 μg/ml) inhibited the siderophore production of P. aeruginosa PAO1 by 69.37%. In addition, HMMN could inhibit pyocyanin production and biofilm formation and erase the formed biofilm of P. aeruginosa PAO1. HMMN (150 μg/ml) inhibited the biofilm formation of P. aeruginosa PAO1 by 28.24%. The erasure rate of the formed biofilm reached 17.03%. Furthermore, HMMN (150 μg/ml) inhibited P. aeruginosa PAO1 pyocyanin production by 36.06%. Meanwhile, positive-control hordenine (500.0 μg/ml) reduced the biofilm formation and pyocyanin production of P. aeruginosa PAO1 by 14.42% and 34.35%, respectively. The erasure rate of hordenine to the formed biofilm is 11.05% at 500 μg/ml. Quantitative real-time polymerase chain reaction (qRT-PCR) showed that HMMN downregulates not only siderophore-related genes but also QS-related genes, as well as hordenine. These results suggest that a siderophore inhibitor could be used as a QS inhibitor to occlude the QS system and reduce virulence.

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Isolation and characterization of arsenic-binding siderophores from Rhodococcus erythropolis S43: role of heterobactin B and other heterobactin variants

Cited by 13 publications

References 34 publications

Novel Nanobiocomposites Based on Natural Polysaccharides as Universal Trophic Low-Dose Micronutrients

Novel Nanobiocomposites Based on Natural Polysaccharides as Universal Trophic Low-Dose Micronutrients

Actinomycete Potential as Biocontrol Agent of Phytopathogenic Fungi: Mechanisms, Source, and Applications

2-Hydroxymethyl-1-methyl-5-nitroimidazole, one siderophore inhibitor, occludes quorum sensing in Pseudomonas aeruginosa

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