A field experiment was carried out at the Extension farm in Province 41 of Husseiniya, Babylon Governorate to study the effect of foliar nutrition with some of nano-fertilizers and nano-amino acids on growth and yield of wheat cultivar Adana 99. The experiment included 8 treatments of Nano chelated super fertilizer (NCSF), nano-amino acids (AA), nano potassium K (NK),di (NCSF +NAA),(NCSF +NK), (NAA+NK), tri (NCSF +NAA+NK) and spray with water only as control for comparison with three replicates in a simple one-way experience using RCBD design. A number of growth criteria in plant and yield (quality and quantity) parameters were recorded. Results indicated that significant response is obvious due to spraying of NCSF followed by the spraying combined of di (NCSF +NAA),(NCSF +NK) and (NAA+NK) tri (NCSF +NAA+NK), treatments respectively in all growth and yield parameters of wheat with an increment of the spray foliar (NCSF) of 81.66 cm, 11.88 cm, 51.99 spad, 118.57,32.66,26.33 and 69.43 µg g−1 for plant height, length of spike, total chlorophyll, concentration of Fe, Cu,Zn and Mn in grain respectively compared to control treatment. The same treatment had grain yield and protein of 5.836 Mg ha−1 and 809.93 kg h−1 compared to control, harvest index were in the range (from 35.37 to 44.57 %) for control and tricombination spraying respectively. The highest grain yield and agronomic productivity was achieved when foliar nutrition of tri nano mixture of (NCSF +NAA+NK) (7.036 Mg h−1 and 2570kg kg−1).