Isolation and characterization of Tha p 1, a major allergen from the pine processionary caterpillar <i>Thaumetopoea pityocampa</i>

Moneo, Ignacio; Vega, José M.; Caballero, M. L.; Vega, Jesús; Alday, E.

doi:10.1034/j.1398-9995.2003.23724.x

Cited by 51 publications

(43 citation statements)

References 15 publications

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“…Gli incidenti provocati da tali insetti derivano da contatti involontari o volontari (curiosità) con le larve o con i loro nidi, nonostante spesso i peli possano essere aerodiffusi e un semplice passaggio, in particolare in aree molto infestate e in giornate ventose, sia sufficiente per innescare reazioni infiammatorie locali (aree esposte) o immunomediate. Nei peli, come già detto, è presente un secreto composto da sostanze urticanti e allergizzanti; in parti- colare, nella processionaria del pino è stata isolata la thaumetopoeina (28 kDa) che, oltre ad avere effetto allergizzante, agisce direttamente sui mastociti inducendone la degranulazione [11][12][13] . Recenti studi hanno poi messo in evidenza frazioni allergeniche del veleno con peso molecolare compreso fra 13 e 45 kDa, nonostante sembri che il maggiore allergene sia rappresentato da una proteina di 15 kDa (Tha p 1) 13 .…”

Section: Le Ep Pi Id Do Ot Tt Te Er Ri Iunclassified

“…Nei peli, come già detto, è presente un secreto composto da sostanze urticanti e allergizzanti; in parti- colare, nella processionaria del pino è stata isolata la thaumetopoeina (28 kDa) che, oltre ad avere effetto allergizzante, agisce direttamente sui mastociti inducendone la degranulazione [11][12][13] . Recenti studi hanno poi messo in evidenza frazioni allergeniche del veleno con peso molecolare compreso fra 13 e 45 kDa, nonostante sembri che il maggiore allergene sia rappresentato da una proteina di 15 kDa (Tha p 1) 13 . La lesione indotta dalle larve di questi insetti è molto complessa ed è data da:…”

Section: Le Ep Pi Id Do Ot Tt Te Er Ri Iunclassified

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Injuries caused by arthropods: diagnostic and therapeutic approach in ER

Moreno

Lauria

2009

Emerg Care J

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I In nt tr ro od du uz zi io on ne e L'entomologia medica in Italia rappresenta una branca delle scienze entomologiche particolarmente negletta che anche presso i corsi di laurea in medicina trova poco spazio. Ciò nonostante gli accessi DEA e le richieste presso gli ambulatori dei medici di medicina generale per incidenti correlati o correlabili a insetti o aracnidi, in particolare nei mesi estivi, non mancano mai anche nel nostro "bel paese", che ha il pregio di non avere specie animali particolarmente pericolose. Sia presso i DEA che presso i medici di base gli incidenti da artropodi pongono molte volte dei formidabili quesiti diagnostici, terapeutici ed educativi (educazione sanitaria) in quanto sussistono svariate difficoltà, quali: 1) identificazione corretta dell'agente lesivo; 2) formulazione di una corretta

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Section: Le Ep Pi Id Do Ot Tt Te Er Ri Iunclassified

Injuries caused by arthropods: diagnostic and therapeutic approach in ER

Moreno

Lauria

2009

Emerg Care J

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“…Immediate hypersensitivity reactions have been documented after exposure to other species of caterpillar (Spiny Elm caterpillar-Nymphalis antiopa) with serum recognition of an allergen of similar molecular weight to Tha p1. The same patient's serum had no recognition of Tha p 1, however; suggesting different caterpillars may have urticating substances which illicit similar responses but utilising different chemicals (proteins, enzymes, etc) (Moneo et al, 2003).…”

Section: Ocular and Dermal Manifestationsmentioning

confidence: 99%

“…This protein contained unique N-terminal amino acids that has no homologies to other described insect allergens, thus the biological function of this protein remains a mystery (Moneo et al, 2003). Immediate hypersensitivity reactions have been documented after exposure to other species of caterpillar (Spiny Elm caterpillar-Nymphalis antiopa) with serum recognition of an allergen of similar molecular weight to Tha p1.…”

Section: Ocular and Dermal Manifestationsmentioning

confidence: 99%

“…Further investigation led to the identification of a protein, Tha p 1 (15 kDa) which elicited a specific Immunoglobulin (Ig) E mediated hypersensitivity reaction (Moneo et al, 2003). This protein contained unique N-terminal amino acids that has no homologies to other described insect allergens, thus the biological function of this protein remains a mystery (Moneo et al, 2003).…”

Section: Ocular and Dermal Manifestationsmentioning

confidence: 99%

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Pathology of equine amnionitis and foetal lLoss: clinical and experimental studies

Todhunter¹

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Detailed experience in identifying the appearance of setal fragments which is highlighted under toluidine blue staining allowed in depth examination of tissues from equine abortions submitted for examination in 2012. Five cases were found in which a caterpillar setal fragment was found in the allantochorion confirming that setal fragments migrate from field exposure as well as experimental exposure to processionary caterpillars.The experiments in this thesis have shown histologically for the first time, the ability of Processionary caterpillar setae to penetrate the maternal gut wall and migrate directly into the uterus and placental tissues. This is considered to be the most likely means of translocation of bacteria to the foetal membranes. The direct, rapid migration of setae in as little as two days from ingestion from the gut to the placenta facilitates bacterial infection.Bacteria present in the mare's gut likely attach to migrating setal fragments and translocate through the gut wall, the uterus and the foetal membranes in which they subsequently colonize. Incomplete migration of setal fragments may account for the focal mucoid placentitis induced when mares were exposed in early gestation. Bacterial colonization of 5 the foetal membranes and/or foetus may cause foetal compromise or death and eventual abortion.The variety of manifestations of EAFL due to the migration of setal fragments ranging from acute abortion, chronic active placentitis, stillbirth, compromised preterm and full term foals, and focal mucoid placentitis have a significant impact on the breeding of horses and ultimately the racing industry in Australia.6

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Arthropods

Monsel

Delaunay

Chosidow

2016

Rook's Textbook of Dermatology, Ninth Edition

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Many arthropod species are capable of inflicting bites and stings on humans. They produce their effects on the skin by a variety of mechanisms, resulting in a wide spectrum of clinical lesions. Reaction to arthropod assaults can range from mild to life threatening. Diagnosis of arthropod bites is often self‐evident, but may be difficult when the source of the bites is not immediately obvious. An entomologist is often invaluable in these situations. Many diseases have arthropods vectors, for example malaria (mosquitoes), leishmaniasis (sandflies) and typhus (lice). The terrestrial arthropods of medical interest include the orders Insecta (insects), Arachnida (arachnida), Chilopoda (centipedes) and Diplopoda (millipedes).

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Isolation and characterization of Tha p 1, a major allergen from the pine processionary caterpillar Thaumetopoea pityocampa

Abstract: This 15-kDa IgE-binding protein is a major caterpillar allergen and shows no homologies to other insect allergens already described.

Cited by 51 publications

References 15 publications

Injuries caused by arthropods: diagnostic and therapeutic approach in ER

Injuries caused by arthropods: diagnostic and therapeutic approach in ER

Pathology of equine amnionitis and foetal lLoss: clinical and experimental studies

Arthropods

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