2015
DOI: 10.1016/j.bmcl.2015.01.056
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Isolation and cytotoxicity evaluation of taxanes from the barks of Taxus wallichiana var. mairei

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Cited by 14 publications
(5 citation statements)
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“…Due to its beautiful tree form, it is often planted in the courtyard as a valuable ornamental tree. Furthermore, Chinese yew is regarded as an important woody medicinal plant because it contains taxol as a natural anti-tumor drug with unique physiological functions in bark, branches and leaves (Sun et al, 2015). The mature Chinese yews form arils which cover the seeds.…”
Section: Introductionmentioning
confidence: 99%
“…Due to its beautiful tree form, it is often planted in the courtyard as a valuable ornamental tree. Furthermore, Chinese yew is regarded as an important woody medicinal plant because it contains taxol as a natural anti-tumor drug with unique physiological functions in bark, branches and leaves (Sun et al, 2015). The mature Chinese yews form arils which cover the seeds.…”
Section: Introductionmentioning
confidence: 99%
“…In particular, we hypothesized that arylation at C6 could provide a rapid route to the cores of taxoids such as taxinine M ( 14 ). , Taxinine M and related taxoids possess a bridging ether ring that distinguishes them from most taxoid natural products. No syntheses of these natural products or their core structures have been reported to date.…”
mentioning
confidence: 99%
“…Cephalomannine is primarily derived from the twigs and leaves of Taxus × media , where it is present in high concentrations and exhibits notable activity. Cephalomannine, found in high concentrations in the twigs and leaves of Taxus × media , shows strong anticancer potential, particularly against breast cancer MCF-7 cells, with a dose-dependent IC50 value of 0.86 µg/m [ 69 ]. It also effectively inhibits P388 lymphocytic leukemia, highlighting its broad-spectrum anticancer activity [ 70 ].…”
Section: Pharmacological Activitymentioning
confidence: 99%