Isolation and in vitro antiamoebic activity of iridoids isolated from Kigelia pinnata

Bharti, Neelam; Singh, Samunder; Naqvi, Fehmida; Azam, Amir

doi:10.3998/ark.5550190.0007.a09

Cited by 33 publications

(12 citation statements)

References 17 publications

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“…Metronidazole used as a reference standard. Verminoside showed a double antiamobic activity compared to the standard drug, while the spicy one showed an activity comparable to metronidazole [18] .…”

Section: Antiamobic Activitymentioning

confidence: 95%

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Comprehension of Phytochemical and pharmacological study of Kigelia Africana (Bignoniaceae)

C¹,

Y²

2020

Int. J. Pharmacognosy Life Sci.

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People thorough out the world use medicinal plants to treat different ailments. Kigelia Africana (Bignoniaceae), commonly known as African sausage tree, is a medicinal plant traditionally used for the treatment of numerous diseases. Kigelia Africana is a deciduous tree, 20-30 m tall and 65 cm in diameter. The plant is described to have a widespread range of therapeutic activities, such as antidiabetic, anticancer, antimalarial, antibacterial, analgesic antileprotic, and antidiarrhoeal, antiinflammatory, antiurolithiasis, antioxidant, etc. The whole plants can be broadly studied for further future potential. The review will provide the information of Kigelia Africana on the account of Pharmacognostic, phytochemical and pharmacological study in a similar way.

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Section: Antiamobic Activitymentioning

confidence: 95%

“…Bharti N et al, 2006 [18] studied the in vitro antiamobic evaluation of isolated iridoids, such as speciosid, verminoside and minecoside. Metronidazole used as a reference standard.…”

Section: Antiamobic Activitymentioning

confidence: 99%

Comprehension of Phytochemical and pharmacological study of Kigelia Africana (Bignoniaceae)

C¹,

Y²

2020

Int. J. Pharmacognosy Life Sci.

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“…Anti-HIV-1 activity of triterpene acid was also reported from Pyrostegia venusta [22]. Iridoids from Kigelia pinnata showed antiamoebic activity [23] and stimulation of GLUT4 translocation [24]. Some phenolic compounds isolated from Pyrostegia venusta were found to have anticandidal and antioxidant activities [25].…”

mentioning

confidence: 92%

Anti-HIV-1 Activities and Chemical Constituents from Leaves and Twigs of Santisukia pagetii (Bignoniaceae)

Limjiasahapong

Tuchinda

Reutrakul

et al. 2018

Natural Product Communications

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The first phytochemical investigation of the leaves and twigs of Santisukia pagetii (Bignoniaceae) using a bioassay-guided fractionation led to the isolation and identification of seventeen known compounds, including four triterpenoids, 3-O-acetylpomolic acid (1), ursolic acid (2), 3-O-acetylursolic acid (3) and siaresinolic acid (4), three iridoid glycosides, specioside (5), verminoside (6) and ambiguuside (7), three flavonoid glycosides, luteolin-7-O-neohesperidoside (8), apigenin-7-O-neohesperidoside (9) and isoquercitrin (10), two phenolic compounds, p-coumaric acid (11) and caffeic acid (12), one monoterpenoid, (6S)-menthiafolic acid (13), together with α-D-glucose (14), β-D-maltose (15), β-sitosterol 3-O-β-D-glucopyranoside (16), a mixture of β-sitosterol (17A) and stigmasterol (17B). Compounds 113 were isolated from Santisukia genus for the first time. In addition, compounds 17, 9 and 10 were found to be active against HIV-1 in anti-syncytium assay, while only compounds 1 and 3 were found to be active (84.4% and 87.2% inhibition at 200 µg/mL, with IC 50 values of 290.96 and 210.34 µM, respectively) against HIV-1 reverse transcriptase. Moreover, anti-HIV-1 activities of compounds 1, 38, and 13 were reported for the first time.

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“…It is widely spread in Sub-Saharan Africa, although rare in some regions. The plant contains naphthoquinones which are active against several protozoal species [8] [9] [10].…”

Section: Introductionmentioning

confidence: 99%

Preliminary Evaluation of Hepatorenal Protective Potentials of <i>Kigelia africana</i> Ethanolic Leaf Extract on Carbon Tetrachloride Induced Toxicity in Adult Male Wistar Rats

Gaiuson¹,

Solomon²,

Yaduma³

et al. 2020

AJPS

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Background and aim: Hepatorenal toxicity is a very common ailment with resultant deleterious burden on the overall body systems and high mortality rate. Although myriads of drug agents are in circulation, its medical management is still inadequate as no effective treatment which inhibits disease progression and complications, has been synthesized yet. Therefore, this study focused on the potentials of Kigelia africana ethanolic leaf extract (KAELE) in preventing hepatorenal toxicity using CCl 4 model of toxicity in rats. Method: KAELE was subjected to phytochemical screening. Following two-week acclimatization, thirty-six (N = 36) adult male Wistar rats were grouped into six consisting of six animals each (n = 6). Group I was given distilled water as control while groups II to VI received silymarin (100 mg/kg), CCl 4 (1 ml/kg), KAELE (100 mg/kg, 200 mg/kg and 400 mg/kg) respectively. All groups pre-treated with silymarin and Kigelia africana ethanol leaf extract lasted for a period of fourteen (14) days using a gastric tube. CCl 4 was administered intraperitoneally to groups II, III, IV, V and VI 48 hours after the last pretreatment on day 14. Post treatment, animals were sacrificed and the blood obtained and sera used for biochemical analysis while the tissues for histological evaluations. Results: The phytochemical tests revealed

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Isolation and in vitro antiamoebic activity of iridoids isolated from Kigelia pinnata

Cited by 33 publications

References 17 publications

Comprehension of Phytochemical and pharmacological study of Kigelia Africana (Bignoniaceae)

Comprehension of Phytochemical and pharmacological study of Kigelia Africana (Bignoniaceae)

Anti-HIV-1 Activities and Chemical Constituents from Leaves and Twigs of Santisukia pagetii (Bignoniaceae)

Preliminary Evaluation of Hepatorenal Protective Potentials of <i>Kigelia africana</i> Ethanolic Leaf Extract on Carbon Tetrachloride Induced Toxicity in Adult Male Wistar Rats

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Isolation and in vitro antiamoebic activity of iridoids isolated from Kigelia pinnata

Cited by 33 publications

References 17 publications

Comprehension of Phytochemical and pharmacological study of Kigelia Africana (Bignoniaceae)

Comprehension of Phytochemical and pharmacological study of Kigelia Africana (Bignoniaceae)

Anti-HIV-1 Activities and Chemical Constituents from Leaves and Twigs of Santisukia pagetii (Bignoniaceae)

Preliminary Evaluation of Hepatorenal Protective Potentials of &lt;i&gt;Kigelia africana&lt;/i&gt; Ethanolic Leaf Extract on Carbon Tetrachloride Induced Toxicity in Adult Male Wistar Rats

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Preliminary Evaluation of Hepatorenal Protective Potentials of <i>Kigelia africana</i> Ethanolic Leaf Extract on Carbon Tetrachloride Induced Toxicity in Adult Male Wistar Rats