Isolation and partial characterization of fucan sulfates from the body wall of sea cucumber Stichopus japonicus and their ability to inhibit osteoclastogenesis

Kariya, Yutaka; Imai, Katsuyuki; Tominaga, Akihiro; Kaneko, T.; Asari, Akira; Suzuki, Kiyoshi; Masuda, Hiroyuki; Kyogashima, Mamoru; Ishii, Tadashi

doi:10.1016/j.carres.2004.02.025

Cited by 132 publications

(90 citation statements)

References 33 publications

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“…8,9 Another interesting sulfated polysaccharide is the sulfated fucan, which displays anticoagulant and antithrombotic activities. 1,10,11 Also known as fucoidan (FC), 12 this substance is found in brown algae (Fucus vesiculosus) and displays an ability to increase the inhibition of thrombin by antithrombin or heparin cofactor II. 1,2 Biopolymers such as CT are considered natural complexing agents, with the ability to form physical gels or coacervates with sulfated polysaccharides.…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of polysaccharide-based nanoparticles with anticoagulant activity

Silva¹,

Garcia²,

Mori³

et al. 2012

IJN

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Abstract:The aim of this study was to produce and characterize nanoparticles (NPs), combining chondroitin sulfate (CS) and fucoidan (FC) with chitosan for therapeutic purposes. These NPs were characterized by dynamic light scattering, zeta potential determination, and transmission electronic microscopy. The anticoagulant activity was determined for FC NPs and compared with FC solution at the same concentration. FC NPs showed regular shapes and better anticoagulant activity than free polysaccharide solution. FC solution did not affect coagulation compared to FC NPs, which increased up to two-fold, even at a lower concentration. Cytotoxicity and permeability tests were conducted using Caco-2 cell monolayer, exhibiting no toxic effect in this cell line and higher permeability for NP2 samples than FC solution at the same concentration.

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Section: Introductionmentioning

confidence: 99%

Preparation and characterization of polysaccharide-based nanoparticles with anticoagulant activity

Silva¹,

Garcia²,

Mori³

et al. 2012

IJN

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“…They contain two polysaccharides: sulfated fucan and fucosylated chondroitin sulfate (CHS). 6,7) As shown in Fig. 1, CHS from sea cucumber is an acid glycosaminoglycan composed of a chondroitin sulfate-E backbone with branches of sulfated fucose at a ratio of approximately 30%, a distinguishing feature different from CHS isolated from other species.…”

mentioning

confidence: 99%

Fucosylated Chondroitin Sulfate from Sea Cucumber in Combination with Rosiglitazone Improved Glucose Metabolism in the Liver of the Insulin-Resistant Mice

Chang

Wang

et al. 2013

Bioscience, Biotechnology, and Biochemistry

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“…The body wall of the sea cucumber is a major edible part and consists mainly of collagen and mucopolysaccharides (Duan et al 2010). In addition, the body wall with peptide, collagen, gelatin, polysaccharide, and saponin has several biological activities such as anticancer, anticoagulation, anti-oxidation, and anti-osteoclastogenesis (Kariya et al 2004;Lu et al 2010;Zhou et al 2012;Yang et al 2015a). Furthermore, sea cucumbers have high applications in the biomedical field because of their regenerative capacities as they can regenerate tissues and organs within a few months (Zohdi et al 2011).…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, new safe and effective antiresorptive drugs are needed. Kariya et al (2004) isolated the two types of fucan sulfate from chloroform/methanol extract of S. japonicus body wall. They used NMR spectroscopy to elucidate the structure of fucan sulfite A and B.…”

Section: Anti-osteoclastogenesismentioning

confidence: 99%

Biological activities and biomedical potential of sea cucumber (Stichopus japonicus): a review

Lee

et al. 2017

Fish Aquatic Sci

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Members of the phylum Echinodermata, commonly known as echinoderms, are exclusively marine invertebrates. Among the Echinodermata, sea cucumber belongs to the family Holothuroidea. The sea cucumber Stichopus (Apostichous) japonicus (Selenka) is an invertebrate animal inhabiting the coastal sea around Korean, Japan, China, and Russia. Sea cucumber has a significant commercial value, because it contains valuable nutrients such as vitamins and minerals. They possess a number of distinctive biologically and pharmacologically important compounds. In particular, the body wall of sea cucumber is a major edible part. It consists of peptide, collagen, gelatin, polysaccharide, and saponin, which possess several biological activities such as anti-cancer, anti-coagulation, anti-oxidation, and antiosteoclastogenesis. Furthermore, the regenerative capacity of sea cucumber makes it a medically important organism. This review presents the various biological activities and biomedical potential of sea cucumber S. japonicus.

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Isolation and partial characterization of fucan sulfates from the body wall of sea cucumber Stichopus japonicus and their ability to inhibit osteoclastogenesis

Cited by 132 publications

References 33 publications

Preparation and characterization of polysaccharide-based nanoparticles with anticoagulant activity

Preparation and characterization of polysaccharide-based nanoparticles with anticoagulant activity

Fucosylated Chondroitin Sulfate from Sea Cucumber in Combination with Rosiglitazone Improved Glucose Metabolism in the Liver of the Insulin-Resistant Mice

Biological activities and biomedical potential of sea cucumber (Stichopus japonicus): a review

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