Isolation and Partial Characterization of a Mycotoxin from Penicillium roqueforti

Wei, Ru‐Dong; Still, P. E.; Smalley, E. B.; Schnoes, Heinrich K.; Strong, F. M.

doi:10.1128/aem.25.1.111-114.1973

Cited by 90 publications

(43 citation statements)

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“…The very low distribution half-life of OTC (6 min) compared to that of OTA (160 min) suggests that esterification of OTA facilitated its penetration in cell, which in turn affects maximal tissue concentrations and overall toxicity. OTC is extremely toxic to animals, such as pig, poultry [464] and dairy cattle [467]. In cell culture it has been recently demonstrated that OTC is more toxic than OTA [468,469].…”

Section: Other Mechanismsmentioning

confidence: 99%

Ochratoxin A: An overview on toxicity and carcinogenicity in animals and humans

Pfohl‐Leszkowicz¹,

Manderville²

2006

Molecular Nutrition Food Res

896

525

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Ochratoxin A (OTA) is a ubiquitous mycotoxin produced by fungi of improperly stored food products. OTA is nephrotoxic and is suspected of being the main etiological agent responsible for human Balkan endemic nephropathy (BEN) and associated urinary tract tumours. Striking similarities between OTA-induced porcine nephropathy in pigs and BEN in humans are observed. International Agency for Research on Cancer (IARC) has classified OTA as a possible human carcinogen (group 2B). Currently, the mode of carcinogenic action by OTA is unknown. OTA is genotoxic following oxidative metabolism. This activity is thought to play a central role in OTA-mediated carcinogenesis and may be divided into direct (covalent DNA adduction) and indirect (oxidative DNA damage) mechanisms of action. Evidence for a direct mode of genotoxicity has been derived from the sensitive 32P-postlabelling assay. OTA facilitates guanine-specific DNA adducts in vitro and in rat and pig kidney orally dosed, one adduct comigrates with a synthetic carbon (C)-bonded C8-dG OTA adduct standard. In this paper, our current understanding of OTA toxicity and carcinogenicity are reviewed. The available evidence suggests that OTA is a genotoxic carcinogen by induction of oxidative DNA lesions coupled with direct DNA adducts via quinone formation. This mechanism of action should be used to establish acceptable intake levels of OTA from human food sources.

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Section: Other Mechanismsmentioning

confidence: 99%

Ochratoxin A: An overview on toxicity and carcinogenicity in animals and humans

Pfohl‐Leszkowicz¹,

Manderville²

2006

Molecular Nutrition Food Res

896

525

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“…It is well known that Penicillium roqueforti is the principal fungus isolated from mouldy silage. Some toxic metabolites such as PR toxin were reported from P roqueforti isolated from mouldy silage (Wei et al 1973). In this paper, the authors report on indole alkaloids and roquefortines from P roqueforti isolated from moulded maize silage.…”

Section: Discussionmentioning

confidence: 93%

Detection of roquefortines in penicillium roqueforti isolated from moulded maize silage

Ohmomo

Kitamoto

Nakajima³

1994

J Sci Food Agric

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A strain (number 19) having the ability to produce some indole alkaloids was isolated from moulded maize silage, and was identical with Penicillium roqueforti. Roquefortine C was isolated from the culture broth in crystalline form as a main alkaloid and was identified as a minor alkaloid by thin-layer chromatography (TLC) in a maize silage inoculated with the strain. Further, roquefortine A, B and D together with festuclavine were identified by TLC. The alkaloid contents in silage were analysed to be 2.40 mg kg-' (roquefortine A) and 1.66 mg kg-' (roquefortine C).

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“…A toxic metabolite, fumigaclavine C, was found in the culture broth of A fumigatus isolated from maize silage (Cole et al 1977) and is structurally very similar to roquefortine A. Wei et al (1973) produced PR-toxin from isolates of Penicillium roqueforti obtained from mouldy silage.…”

Section: Storage Derived Mycotoxinsmentioning

confidence: 99%

Occurrence and significance of mycotoxins in forage crops and silage: a review

Scudamore¹,

Livesey

1998

J. Sci. Food Agric.

176

127

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Study of mycotoxins in animal feeding stuffs has concentrated on the occurrence of aflatoxins and, to a lesser extent, other mycotoxins in cereals, raw materials and concentrate feeds. However, ruminant diets contain a high proportion of forage crops such as grass or maize silage, hay and straw. Under adverse growing, production or storage conditions, fungal spoilage is likely to occur with some degree of mycotoxin contamination. The mould flora of forage crops is likely to differ significantly from that of cereals and mycotoxin contamination, should it occur, could differ qualitatively and quantitatively. Information relating to forage crops as a potential source of mycotoxins is reviewed. Some field incidents and animal disease which may be mycotoxin related are discussed and analytical methods are reviewed. Information on dose and effect of candidate mycotoxins is given where available. The review suggests areas which the authors consider merit further study. Crown Copyright 1998.

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Isolation and Partial Characterization of a Mycotoxin from Penicillium roqueforti

Cited by 90 publications

References 0 publications

Ochratoxin A: An overview on toxicity and carcinogenicity in animals and humans

Ochratoxin A: An overview on toxicity and carcinogenicity in animals and humans

Detection of roquefortines in penicillium roqueforti isolated from moulded maize silage

Occurrence and significance of mycotoxins in forage crops and silage: a review

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