Isolation and speciation of genus candida in patients undergoing chemotherapy and radiotherapy for head and neck tumours

Yogitha, P. V. V.; Lakshmi, N.; Lakshmi, Koripella Rama; Krishna, Perala Bala Murali; Cheemala, Sulakshana Sony

doi:10.5455/2320-6012.ijrms20150529

Cited by 7 publications

(15 citation statements)

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“…However, the use of sodium fluoride in aqueous solutions or gel minimizes the changes of cariogenic cocci populations, constituting a recognized strategy to prevent the rampant caries associated with RT and xerostomia [30][31][32] . Then, the elevations of cariogenic microorganisms in RT might be understood as result of the absence or precariousness of the preventive measures and the poor hygiene conditions of the patients and their deterioration along RT 33,34 . In radiotherapy centers where preventive dentistry is considered relevant and plays a central role in the prevention of side effects of RT, populations of cariogenic cocci are under partial control 19,30 , consisting transient phenomenon 33,35,36 , and hygiene standards evidences relevant improvement during RT and follow-up period, particularly when intensity modulated radiation therapy is used, which produces less pronounced effects on the salivary glands 19,37 .…”

Section: Radiation Caries Oral Streptococci and Mucositismentioning

confidence: 99%

“…This phenomenon is also exacerbated by the acidification of the oral biofilm and the reduction of the buffer capacity of the residual saliva. The prevalence and populations of yeasts are directly related to RT 23,34,44 , being involved in the severity of mucositis and secondary infections.…”

Section: Radio-induced Mucositis and Candidiasismentioning

confidence: 99%

“…On the other hand, as opportunistic pathogens, the high prevalence and populations of fungi also reflect the poor conditions of oral hygiene and deterioration along the RT 34 , as well nutritional deficiencies and loss of weight in irradiated patients. Oral candidiasis in RT patients might also be associated to the exacerbation of virulence of the fungi 40 .…”

Section: Radio-induced Mucositis and Candidiasismentioning

confidence: 99%

“…varies from 20 to 70% in patients undergoing RT, and some studies suggest that other species besides C. albicans are more favored in the irradiated patients 7,45 . However, literature has failed to discover any advantage for non-albicans Candida during or after RT 23,34,44,46,47 . The prevention/control of oral candidiasis, by improving oral hygiene standards, use of antifungal solutions and nutritional support, could also be a measure with impact on mucositis intensity in irradiated patients 7,34 , particularly the systemic use of fluconazole and aqueous solution of nystatin 20,21,34,47 .…”

Section: Radio-induced Mucositis and Candidiasismentioning

confidence: 99%

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Oral microbiota and mucositis in patients with head and neck cancer undergoing radiotherapy: literature review

Jardim¹,

Cunha-Correia²,

Okamoto³

et al. 2017

Arch Health Invest

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Oral microbiota and mucositis in patients with head and neck cancer undergoing radiotherapy: literature review AbstractThe occurrence and severity of mucositis are the main complaints of patients with head and neck cancer submitted to radiotherapy (RT). This condition appears to be associated with changes in the oral microbiota and other side effects of RT, such as xerostomia and candidiasis. The aim of this study was to evaluate the effect of RT on the oral microbiota and its impact on radioinduced mucositis through literature review. Descriptors were selected for the collection of information in different databases, especially SciELO, BIREME, LILACS and PubMed. It was decided to consider only articles published since 1985. The descriptors radiotherapy, mucositis, dental caries, xerostomia, head and neck neoplasms and health promotion were used. It was selected 91 articles specifically discussing the microbiological aspects of mucositis, dental caries, oral candidiasis and microbial effects on the oral health of cancer patients, and 59 were included in the review. It was observed that microbial contamination is a secondary phenomenon capable of exacerbate the inflammation induced by the interaction of the radiation with the oral tissues, aggravating mucositis mainly in patients who present precarious conditions of oral hygiene, which reinforces the role of preventive dentistry in the follow up of the irradiated patient. Descriptors: Radiotherapy; Mucositis; Dental Caries; Xerostomia; Head And Neck Neoplasms; Health Promotion. ResumoA ocorrência e a severidade da mucosite constituem as principais queixas dos pacientes com câncer de cabeça e pescoço submetidos à radioterapia (RT). Essa condição parece estar associada às modificações da microbiota bucal e aos demais efeitos colaterais da RT, como xerostomia e a candidíase. O presente trabalho de revisão da literatura teve como objetivo avaliar o efeito que a RT exerce sobre a microbiota bucal e seu impacto na mucosite radioinduzida através de revisão de literatura. Foram selecionados os descritores para a coleta de informações em diferentes bancos de dados, destacando-se SciELO, BIREME, LILACS e PubMed. Decidiu-se considerar apenas artigos publicados desde 1985. Utilizou-se como descritores os termos radioterapia, mucosite, cárie dentária, xerostomia, neoplasias de cabeça e pescoço e promoção da saúde. Foram selecionados 91 artigos que discutiam especificamente os aspectos microbiológicos da mucosite, cárie dentária, candidíase oral e efeitos microbianos na saúde bucal de pacientes oncológicos e 59 foram incluídos na revisão. Observou-se que a contaminação microbiana é fenômeno secundário capaz de agravar a inflamação induzida pela interação da radiação com os tecidos bucais, agravando-se, principalmente, em pacientes que apresentam condições precárias de higiene bucal, o que reforça o papel da odontologia preventiva no acompanhamento do paciente irradiado. Descritores: Radioterapia; Mucosite; Cárie Dentária; Xerostomia; Neoplasias de Cabeça e Pescoço; Promoção da...

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Section: Radiation Caries Oral Streptococci and Mucositismentioning

confidence: 99%

Section: Radio-induced Mucositis and Candidiasismentioning

confidence: 99%

Section: Radio-induced Mucositis and Candidiasismentioning

confidence: 99%

Section: Radio-induced Mucositis and Candidiasismentioning

confidence: 99%

See 2 more Smart Citations

Oral microbiota and mucositis in patients with head and neck cancer undergoing radiotherapy: literature review

Jardim¹,

Cunha-Correia²,

Okamoto³

et al. 2017

Arch Health Invest

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show abstract

“…26 Although inadequate nutrition could be a reason due to mucositis and thus inability to eat, the subjects in our study were given oral prophylaxis prior to RT and the teeth with poor prognosis were extracted, hence, the reason of poor oral hygiene could be safely excluded from our study as a causative factor.…”

mentioning

confidence: 99%

Changes in Candida Profile in Patients Undergoing Intensity Modulated Radiotherapy for Head and Neck Malignancies

Kamath¹,

Kini²,

Naik³

et al. 2017

J Dent Indones

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The increased oral Candida colonization that resulted for radiotherapy often leads to candidiasis. Intensity Modulated Radiotherapy (IMRT) is a technique of delivering radiation with improved dose distributions sparing the surrounding normal tissue and decreasing the ill-effects. Objective: To identify and quantify changes in the Candidal carriage of patients undergoing IMRT for head and neck malignancy. Methods: Saliva from 37 patients undergoing IMRT for head and neck malignancy was collected. The Candida species profile pre-and post-IMRT was evaluated using semi quantitative fungal culture. The changes in the distribution of the growth of Candida species due to IMRT was analyzed using Wilcoxon sign rank test. Results: Twenty-two patients were Candidapositive pre-IMRT, while 24 patients were Candida-positive post-IMRT. Candida species isolates pre-IMRT were C. albicans (63%), C. tropicalis (26%), C. glabrata (7%), C. krusei (4%) and post-IMRT, were C. albicans (55%), C. tropicalis (30%), C. glabrata (12%) and C. krusei (3%). C. albicans showed increased growth post-IMRT in the range of 10 3 to 10 4 colony-forming units per ml of saliva (p>0.05). Conclusion: There was no significant effect of IMRT on the distribution of growth of Candida. Candida albicans was the most common species. A change towards non C. albicans species post-IMRT was seen.

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Supragingival and subgingival microbiota from patients with poor oral hygiene submitted to radiotherapy for head and neck cancer treatment

Gaetti‐Jardim

Jardim

Schweitzer

et al. 2018

Archives of Oral Biology

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Isolation and speciation of genus candida in patients undergoing chemotherapy and radiotherapy for head and neck tumours

Cited by 7 publications

References 0 publications

Oral microbiota and mucositis in patients with head and neck cancer undergoing radiotherapy: literature review

Oral microbiota and mucositis in patients with head and neck cancer undergoing radiotherapy: literature review

Changes in Candida Profile in Patients Undergoing Intensity Modulated Radiotherapy for Head and Neck Malignancies

Supragingival and subgingival microbiota from patients with poor oral hygiene submitted to radiotherapy for head and neck cancer treatment

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