Isolation and Structural Characterization of a Cytotoxic L-Amino Acid Oxidase from Agkistrodon contortrix laticinctus Snake Venom: Preliminary Crystallographic Data

Souza, Dulce Helena Ferreira de; Eugenio, Luiz; Fletcher, Jeffrey E.; Jiang, Ming-Shi; Garratt, R.C.; Oliva, Glaucius; Selistre-de-Araújo, Heloísa Sobreiro

doi:10.1006/abbi.1999.1287

Cited by 95 publications

(75 citation statements)

References 27 publications

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“…Diverse studies have indicated that LAAOs have broad bioactivities such as inducing apoptosis [1], cytotoxicity [2,3], edema [4], hemolysis [5], hemorrhage [6], inducing or inhibiting platelet aggregation [7,8], parasite-killing activity [9], and antimicrobial activity [10]. LAAO may act as defence or attack weapons via H 2 O 2 [11] or as ideal molecular mechanisms for the acquisition of nitrogen from diverse amino acid sources [12].…”

Section: Nhmentioning

confidence: 99%

Isolation and Characterization of an L-Amino Acid Oxidase-Producing Marine Bacterium

Yu¹,

Qiao²,

Qiu³

et al. 2013

ENG

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One marine bacterial strain, R3, has been newly isolated from the intertidal zone of Dinghai sea area. Measurements of a-keto acids and H 2 O 2 existing in fermentation supernatant were carried out to show that R3 can produce L-amino acid oxidase (LAAO) with a broad substrate specificity. Physiological and biochemical analysis showed that it can grow great at the conditions with sodium chloride concentration of 1.5% -3%, temperature of 15˚C -35˚C and pH of 6 -7. In addition, molecular identification of 16S rDNA was performed to show that R3 was proximal to Pseudoalteromonas spp. with the highest identity of 98.5% to Pseudoalteromonas rubra. Therefore, it was designated as Pseudoalteromonas sp. R3. Further studies are required to arrive at a better understanding of this LAAO and secure an application.

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Section: Nhmentioning

confidence: 99%

Isolation and Characterization of an L-Amino Acid Oxidase-Producing Marine Bacterium

Yu¹,

Qiao²,

Qiu³

et al. 2013

ENG

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“…Apoptose tem sido definida como morte celular programada, caracterizada pelo ilustre exemplo de eventos celulares morfológicos e bioquímicos (Souza et al, 1999). Araki et al (1993) (Torii et al, 2000), células de leucemia humana promielocítica (HL-60) (Torii et al, 1997), células de leucemia T humanas (MOLT-4) (Suhr and Kim, 1996), células monocíticas humanas (MM6) com confirmação da apoptose pela fragmentação do DNA das células tratadas com LAAO (Ali et al, 2000).…”

Section: As L-aminoácido Oxidades -Laaosunclassified

“…A morte celular para células normais (macrófagos) foi insignificante. Além disso, BpirLAAO-I foi capaz de induzir a fragmentação de DNA após a incubação a 37°C por 24h (Izidoro et al, 2006 (Souza et al, 1999;Chung;Tan, 1994;Tan;Swaminathan, 1992;Tan;Saifuddin, 1989;Tsuruo, 1997;Abe et al, 1998;Clemetson, 2002;Ali et al, 2000;Toyama et al, 2006;Samel, et al, 2006 …”

Section: As L-aminoácido Oxidades -Laaosunclassified

“…9). Souza et al (1999) Crotalus durissus cascavella -68 kDa (Toyama et al, 2006). A massa molecular relativa (Mr) das LAAOs isoladas de C. rhodostoma Chung;Tan, 1994), B. alternatus , B. pirajai (Izidoro et al, 2006) A fração BaPI originada da filtração do veneno bruto em Sephadex G-75 (Fig.…”

Section: Figura 22unclassified

“…20) apresentou atividade hemorrágica similar à do veneno de B. atrox, demonstrando assim, ser a responsável pela atividade hemorrágica do mesmo (Figura 20-A e B). Souza et al (1999) descreveram o isolamento e a caracterização de uma LAAO de A. contortrix laticinctus que apresenta atividade hemorrágica. A fração BaPI apresenta as enzimas proteolíticas…”

Section: Figura 22unclassified

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Isolation and Structural Characterization of a Cytotoxic L-Amino Acid Oxidase from Agkistrodon contortrix laticinctus Snake Venom: Preliminary Crystallographic Data

Cited by 95 publications

References 27 publications

Isolation and Characterization of an L-Amino Acid Oxidase-Producing Marine Bacterium

Isolation and Characterization of an L-Amino Acid Oxidase-Producing Marine Bacterium

Isolamento e caracterização bioquímica e funcional de L-aminoácido oxidase do veneno de 'Bothrops atrox'

The Recent Developments of Enzymatic Oxidation

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