Isolation and Structural Studies on Saponins from Three Cephalaria Species from Anatolia

Çelenk, Veysel Umut; Sarikahya, Nazli Boke; Kirmizigul, Suheyla

doi:10.1007/s10600-020-02980-w

Cited by 7 publications

(2 citation statements)

References 33 publications

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“…These annual and perennial plants [ 17 , 18 ] occur mainly in Europe, East Asia, East Mediterranean and Central Africa [ 19 ]. Cephalaria species are rich in triterpene saponins [ 20 , 21 , 22 , 23 ], iridoids [ 24 ], alkaloids [ 25 ] and flavonoids [ 26 ], which are responsible for, for example, cytotoxic [ 23 , 27 ], immunomodulatory [ 23 ], antibacterial [ 17 , 28 ], antifungal [ 29 ] and hypoglycemic [ 30 ] activities.…”

Section: Introductionmentioning

confidence: 99%

Extracts from Cephalaria Uralensis (Murray) Roem. & Schult. and Cephalaria Gigantea (Ledeb.) Bobrov as Potential Agents for Treatment of Acne Vulgaris: Chemical Characterization and In Vitro Biological Evaluation

et al. 2020

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The aim of this study was to compare the chemical composition, as well as antioxidant, anti-inflammatory, antiacne, and cytotoxic activites of various extracts of Cephalaria gigantea and C. uralensis. It is worth underlining that we are the first to characterize the composition and evaluate the biological properties of extracts from Cephalaria gigantea and C. uralensis. Thus, the LC-DAD-MS3 analysis revealed the presence of 41 natural products in studied extracts. The 5-O-caffeoylquinic acid, isoorinetin, and swertiajaponin were the main detected compounds. Among the tested samples, ethanol extract of the aerial parts of C. uralensis (CUE) possessed the most suitable biological properties. It exhibited moderate ability to scavenge free radicals and good capacity to inhibit cyclooxygenase-1, as well as cyclooxygenase-2. Moreover, CUE possessed moderate antibacterial activity against all tested bacterial strains (S. aureus, S. epidermidis, and P. acnes), and importantly, it was non-toxic towards normal skin fibroblasts. Taking into account the value of calculated therapeutic index (>10), it is worth noting that CUE can be subjected to in vivo study. Thus, CUE constitutes a very promising antiacne agent.

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Section: Introductionmentioning

confidence: 99%

Extracts from Cephalaria Uralensis (Murray) Roem. & Schult. and Cephalaria Gigantea (Ledeb.) Bobrov as Potential Agents for Treatment of Acne Vulgaris: Chemical Characterization and In Vitro Biological Evaluation

et al. 2020

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“…Species of the genus Cephalaria are usually perennial plants with lanceolate or pinnate leaves and spherical inflorescences developing on long, erect shoots [ 9 ]. Previous studies have shown that species belonging to the genus Cephalaria are rich in iridoids [ 10 , 11 ], flavonoids [ 10 , 12 ], caffeic acid derivatives [ 10 ], triterpene saponins [ 13 , 14 , 15 , 16 ], and alkaloids [ 17 ]. Due to the presence of a variety of chemical constituents, these plants are attractive species from a medicinal perspective.…”

Section: Introductionmentioning

confidence: 99%

Biotechnological Potential of Cephalaria uralensis (Murray) Roem. & Schult. and C. gigantea (Ledeb.) Bobrov—Comparative Analysis of Plant Anatomy and the Content of Biologically Active Substances

Chrząszcz

Szewczyk

Tchórzewska

2021

Plants

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Studies conducted to date have shown that Cephalaria uralensis and C. gigantea have high contents of substances with antibacterial, anti-inflammatory, and antioxidant properties; hence, they are attractive plants from the pharmaceutical point of view. However, despite their multifarious desirable biotechnological aspects, the knowledge of these plants is insufficient. The present study focused on the analysis of the morphological, anatomical, and histological structure of aboveground parts of the plants, the identification of the distribution of biologically active compounds in the tissues, and quantitative phytochemical analyses of polyphenolic compounds contained in their aboveground organs. Importantly, the phenological and morphological features of the aboveground organs in the analyzed species were maintained, as in the same plant species growing in different climatic conditions. The analysis of primary metabolites and phenolic compounds in the tissues revealed their distribution in the aboveground organs, which has never been described before. The comparative analyses of the content of total phenolics, total phenolic acids, and total flavonoids in the aboveground organs showed that the level of these substances differed not only between the species but also between the organs. It should be emphasized that the level of these compounds is higher than in many other medicinal plants.

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Ecophysiological responses of endemic Cephalaria duzceënsis to drought and salt stress

Torun

Aydın²

2022

Biologia

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Isolation and Structural Studies on Saponins from Three Cephalaria Species from Anatolia

Cited by 7 publications

References 33 publications

Extracts from Cephalaria Uralensis (Murray) Roem. & Schult. and Cephalaria Gigantea (Ledeb.) Bobrov as Potential Agents for Treatment of Acne Vulgaris: Chemical Characterization and In Vitro Biological Evaluation

Extracts from Cephalaria Uralensis (Murray) Roem. & Schult. and Cephalaria Gigantea (Ledeb.) Bobrov as Potential Agents for Treatment of Acne Vulgaris: Chemical Characterization and In Vitro Biological Evaluation

Biotechnological Potential of Cephalaria uralensis (Murray) Roem. & Schult. and C. gigantea (Ledeb.) Bobrov—Comparative Analysis of Plant Anatomy and the Content of Biologically Active Substances

Ecophysiological responses of endemic Cephalaria duzceënsis to drought and salt stress

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