Isolation and Structure Elucidation of a New Antifungal and Antibacterial Antibiotic Produced by Streptomyces sp. 201

Bordoloi, Gajen N.; Kumari, Babita; Guha, Arun K.; Bordoloi, Manobjyoti; Yadav, Rajkumar; Roy, Monoj K.; Bora, Tarun C.

doi:10.1271/bbb.65.1856

Cited by 47 publications

(32 citation statements)

References 5 publications

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“…5, 10, 15 and 20 ll were used to evaluate the efficiency of antimicrobial activity against all the pathogens tested. After incubation, MIC was defined as the lowest concentration that produced maximum zone of inhibition against test pathogens [21].…”

Section: Determination Of Minimum Inhibitory Concentration (Mic)mentioning

confidence: 99%

Optimization of Antimicrobial Production by a Marine Actinomycete Streptomyces afghaniensis VPTS3-1 Isolated from Palk Strait, East Coast of India

et al. 2011

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Totally 25 marine soil samples were collected from the region of Palk Strait of Bay of Bengal, Tamil Nadu, and were subjected to the isolation of actinomycetes. Sixty-eight morphologically distinct isolates were obtained and 37% (25) of them had antimicrobial activity. The potential producer was named as Streptomyces sp. VPTS3-1 and the phylogenetic evaluation on the basis of 16S rDNA sequence further categorized the organism as Streptomyces afghaniensis VPTS3-1. Further, the antimicrobial compound was extracted from the isolate using various solvents and the antimicrobial efficacies were tested against bacterial and fungal pathogens. In addition, in vitro optimization of parameters for the antimicrobial compound production revealed that the suitable pH as 7-8, the period of incubation as 9 days, temperature (30°C), salinity (2%), and starch and KNO 3 as the suitable carbon and nitrogen sources respectively in starch-casein medium.

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Section: Determination Of Minimum Inhibitory Concentration (Mic)mentioning

confidence: 99%

Optimization of Antimicrobial Production by a Marine Actinomycete Streptomyces afghaniensis VPTS3-1 Isolated from Palk Strait, East Coast of India

et al. 2011

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“…Moreover 2MHI does not violate Lipinski rule of five as shown in Table 3 where the rule describes molecular properties important for a drug's pharmacokinetics in the human body, including their absorption, distribution, metabolism, and excretion (''ADME'') [33]. Additionally the ground work on screening of antibacterial assay conducted by also proved that it has a strong anti-bacterial activity [18].…”

Section: Resultsmentioning

confidence: 95%

“…Antibacterial Assay and MIC Conducted by A screening work on anti-bacterial assay of 2MHI and Isoniazid-an anti-tuberculotic drug has been conducted by showing 2MHI having a strong antibacterial property against Bacillus subtilis, E. coli, Proteus mirabilis, Arthrobacter, Shigella and Klebsiella species as compared to Isoniazid which is shown in Table 1 [18].…”

Section: Filter For Lipinski Rule Of Fivementioning

confidence: 99%

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Molecular Interaction of Novel Compound 2-Methylheptyl Isonicotinate Produced by Streptomyces sp. 201 with Dihydrodipicolinate Synthase (DHDPS) Enzyme of Mycobacterium tuberculosis for its Antibacterial Activity

2012

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Antibiotic resistance is a growing problem in multi-drug-resistant tuberculosis which is caused by Mycobacterium tuberculosis (MTB). Hence there is an urgent need for designing or developing a novel or potent anti-tubercular agent. The Lysine/DAP biosynthetic pathway is a promising target because of its role in cell wall and amino acid biosynthesis. In our study we performed a molecular docking analysis of a novel antibacterial isolated from Streptomyces sp. 201 at three different binding site of dihydrodipicolinate synthase (DHDPS) enzyme of MTB. The molecular docking studies suggest that the novel molecule shows favourable interaction at the three different binding sites as compared to five experimentally known inhibitors of DHDPS.

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“…The crude bioactive molecule was isolated from the culture broth by solvent extraction method using ethyl acetate in the ratio of 1:1 (Bordoloi et al, 2001). …”

Section: Antifungal Assaymentioning

confidence: 99%

Impact of Pseudomonas aeruginosa MAJ PIA03 affecting the growth and phytonutrient production of castor, a primary host-plant of Samia ricini

Sandilya

Bhuyan

Nageshappa

et al. 2017

J. Soil Sci. Plant Nutr.

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Castor (Ricinus communis L.) is a primary food plant of eri silkworm, Samia ricini Donovan endemic to Northeast India. Plant growth promoting rhizobacteria (PGPR) plays crucial role in growth and productivity of agricultural crops. Eighty-five Pseudomonas strains were isolated from thirty rhizosphere soil samples of castor and their in vitro potentiality was screened for growth promoting ability and antifungal potentialities. Most of the selected Pseudomonas sp. produced indole acetic acid, gibberellic acid, ACC deaminase activity, ammonia, hydrogen cyanide and siderophore, when tested in-vitro for PGP activity. Besides, the strains MAJ PIA01, MAJ PIA03 and MAJ PIA24 have got antifungal activity against five common plant pathogens. Upon their formulation and application in field by curtailing the recommended dose of inorganic fertilizers to 50 %, isolate no. MAJ PIA03 efficiently enhanced the agronomical traits such as number of leaves per plant, leaf biomass, root length, stem base diameter, shoot length, root biomass and leaf moisture content. Isolate no. MAJ PIA03 has significant impact on leaf biochemical constituents and augments the nutritional quality of castor leaf. The most efficient isolate MAJ PIA03 was identified as Pseudomonas aeruginosa MAJ PIA03 by polyphasic approach and its 16S rRNA gene homology. The bio-formulation of Pseudomonas aeruginosa MAJ PIA03 with 50 % diminution on recommended inorganic NPK dose could be used as an effective mechanism to improve Ricinus communis plant growth as well as leaf nutritional enhancement for sustainable eri sericulture.

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Isolation and Structure Elucidation of a New Antifungal and Antibacterial Antibiotic Produced by Streptomyces sp. 201

Cited by 47 publications

References 5 publications

Optimization of Antimicrobial Production by a Marine Actinomycete Streptomyces afghaniensis VPTS3-1 Isolated from Palk Strait, East Coast of India

Optimization of Antimicrobial Production by a Marine Actinomycete Streptomyces afghaniensis VPTS3-1 Isolated from Palk Strait, East Coast of India

Molecular Interaction of Novel Compound 2-Methylheptyl Isonicotinate Produced by Streptomyces sp. 201 with Dihydrodipicolinate Synthase (DHDPS) Enzyme of Mycobacterium tuberculosis for its Antibacterial Activity

Impact of Pseudomonas aeruginosa MAJ PIA03 affecting the growth and phytonutrient production of castor, a primary host-plant of Samia ricini

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