Isolation and structure of a peptide toxin from the marine snail Conus magus

Mcintosh, Max E.; Cruz, Lourdes J.; Hunkapiller, Michael W.; Gray, William R.; Olivera, Baldomero M.

doi:10.1016/0003-9861(82)90351-4

Cited by 192 publications

(98 citation statements)

References 7 publications

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“…The latest example of development of a toxin into an approved drug by the US Food and Drug Administration (FDA) (December 2004) is ziconotide (Prialt Ò ), a synthetic non-opioid, non-NSAID, non-local anesthetic drug originating from the cone snail Conus magus peptide x-conotoxin M-VII-A, an N-type calcium channel blocker. Discovered in the early 1980s [8], zicotonide is a rare example of a molecule used unaltered from a creature's chemistry. Prialt Ò is used for the amelioration of chronic untreatable pain, and due to the profound side effects or lack of efficacy when delivered through more common routes, such as orally or intravenously, Prialt Ò must be administered directly into the spine.…”

Section: The Ying and Yang Of Animal Venomsmentioning

confidence: 99%

Venoms, venomics, antivenomics

et al. 2009

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a b s t r a c tVenoms comprise mixtures of peptides and proteins tailored by Natural Selection to act on vital systems of the prey or victim. Here we review our proteomic protocols for uncoiling the composition, immunological profile, and evolution of snake venoms. Our long-term goal is to gain a deep insight of all viperid venom proteomes. Knowledge of the inter-and intraspecies ontogenetic, individual, and geographic venom variability has applied importance for the design of immunization protocols aimed at producing more effective polyspecific antivenoms. A practical consequence of assessing the cross-reactivity of heterologous antivenoms is the possibility of circumventing the restricted availability of species-specific antivenoms in some regions. Further, the high degree of target specificity makes toxins valuable scaffolds for drug development.

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Section: The Ying and Yang Of Animal Venomsmentioning

confidence: 99%

Venoms, venomics, antivenomics

et al. 2009

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“…Steroids are generally used as an adjunct therapy with opioids and are beneficial to patients with metastatic bone pain, visceral pain and neuropathic pain [7]. Ziconotide, a natural peptide from snail venom, is approved for the treatment of intractable chronic pain [8,9]. Ziconotide administration is limited to intrathecal because of cardiovascular liabilities caused by the intravenous route [10].…”

Section: Therapeutics For Chronic Neuropathic Painmentioning

confidence: 99%

Dynorphin a Analogs for the Treatment of Chronic Neuropathic Pain

2016

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Chronic pain is one of the most ubiquitous diseases in the world, but treatment is difficult with conventional methods, due to undesirable side effects of treatments and unknown mechanisms of pathological pain states. The endogenous peptide, dynorphin A has long been established as a target for the treatment of pain. Interestingly, this unique peptide has both inhibitory (opioid in nature) and excitatory activities (nonopioid) in the CNS. Both of these effects have been found to play a role in pain and much work has been done to develop therapeutics to enhance the inhibitory effects. Here we will review the dynorphin A compounds that have been designed for the modulation of pain and will discuss where the field stands today.

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“…Olivera's group has found that it blocks a specific type of calcium channel that has been implicated in chronic neuropathic pain, caused by damage to the nervous system 4 . The toxin has since been developed as a drug called ziconotide and is now in advanced clinical trials for patients with cancer and AIDS who are suffering from pain that cannot be relieved by opiates 5 .…”

Section: One Snail's Poison…mentioning

confidence: 99%

One slip, and you're dead...

Nelson¹

2004

Nature

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Isolation and structure of a peptide toxin from the marine snail Conus magus

Cited by 192 publications

References 7 publications

Venoms, venomics, antivenomics

Venoms, venomics, antivenomics

Dynorphin a Analogs for the Treatment of Chronic Neuropathic Pain

One slip, and you're dead...

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