2021
DOI: 10.3390/life11080825
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Isolation, Characterization and Neuroprotective Activity of Folecitin: An In Vivo Study

Abstract: Neurodegenerative diseases (NDs) extend the global health burden. Consumption of alcohol as well as maternal exposure to ethanol can damage several neuronal functions and cause cognition and behavioral abnormalities. Ethanol induces oxidative stress that is linked to the development of NDs. Treatment options for NDs are yet scarce, and natural product-based treatments could facilitate ND management since plants possess plenty of bioactive metabolites, including flavonoids, which typically demonstrate antioxida… Show more

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Cited by 26 publications
(13 citation statements)
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“…CCL2 is one of the key chemokines regulating monocyte/macrophage migration and infiltration. Its reduction can improve inflammation and POI [ 24 ]. As an inflammatory mediator, IL-1 β directly affects the symptoms of POI (gas, defecation, nausea, vomiting, and so on).…”
Section: Discussionmentioning
confidence: 99%
“…CCL2 is one of the key chemokines regulating monocyte/macrophage migration and infiltration. Its reduction can improve inflammation and POI [ 24 ]. As an inflammatory mediator, IL-1 β directly affects the symptoms of POI (gas, defecation, nausea, vomiting, and so on).…”
Section: Discussionmentioning
confidence: 99%
“…An estimation reported that approximately 75–80% of the world’s population uses traditional medical systems as their first therapy option due to lack of access to treatment facilities as well as worries about synthetic medicine safety and efficacy [ 144 , 145 ]. On the other hand, natural products have grown in importance as sources of polypharmacological treatments for infectious diseases, malignancies, and neurological disorders [ 146 , 147 ]. Moreover, references to plants in religious texts have prompted more scholars to examine the scientific validity of traditional claims [ 148 , 149 , 150 ].…”
Section: Treatment Strategiesmentioning
confidence: 99%
“…According to World Health Organization (WHO), 75–80% of the world’s population solely rely on traditional medical systems for their first line of treatment due to concerns about the safety and efficacy of synthetic drugs ( Hossain et al, 2014 ; Urbi and Zainuddin, 2015 ; Hossain and Urbi, 2016 ; Hossain M. S. et al, 2021 ). On the contrary, for being comparatively safe, natural products have gained tremendous importance as sources of polypharmacological drugs for infectious diseases, cancers, and neurological disorders ( Hossain S. et al, 2021 ; Farooq et al, 2021 ). Moreover, indications of the importance of plants for diverse ailments in religious scripts attracted more researchers focusing on evaluating the scientific validity of traditional claims ( Hossain et al, 2014 ; Hossain, 2016 ; Hossain et al, 2016 ).…”
Section: Introductionmentioning
confidence: 99%